PMID- 28990745
OWN - NLM
STAT- MEDLINE
DCOM- 20180816
LR  - 20180816
IS  - 1827-1839 (Electronic)
IS  - 0392-9590 (Linking)
VI  - 37
IP  - 1
DP  - 2018 Feb
TI  - Diagnostic value of circulating microRNA-27a/b in patients with acute pulmonary 
      embolism.
PG  - 19-25
LID - 10.23736/S0392-9590.17.03877-9 [doi]
AB  - BACKGROUND: Circulating microRNAs (miRNAs) have been increasingly suggested as 
      biomarkers for numerous diseases. The aims of this study were to evaluate the 
      expression of plasma miR-27a/b in patients with acute pulmonary embolism (APE) 
      and determine the possibility of miR-27a/b as diagnostic biomarkers for APE. 
      METHODS: Seventy-eight APE patients diagnosed by computed tomographic pulmonary 
      angiography (CTPA) and 70 age and gender matched normal volunteers were included 
      in this study. The levels of miR-27a and miR-27b were measured by quantitative 
      reverse transcription-polymerase chain reaction (qRT-PCR) and the concentrations 
      of plasma D-dimer were measured using immunoturbidimetric assay. RESULTS: The 
      levels of plasma miR-27a and miR-27b were significantly higher in APE patients 
      (P<0.001) compared with normal controls. Receiver operating characteristic (ROC) 
      curve analyses showed that plasma miR-27a was superior to miR-27b for the 
      diagnosis of APE (AUC=0.784, AUC=0.707, respectively). Combining miR-27a or 
      miR-27b with D-dimer significantly increased the diagnostic capacity of APE. 
      CONCLUSIONS: Our results showed that circulating miR-27a and miR-27b might be 
      potential novel diagnostic biomarkers in APE patients.
FAU - Wang, Qian
AU  - Wang Q
AD  - Department of Clinical Laboratory, the First Affiliated Hospital of Zhengzhou 
      University, Key Laboratory of Laboratory Medicine of Henan Province, Zhengzhou, 
      Henan, China.
FAU - Ma, Junfen
AU  - Ma J
AD  - Department of Clinical Laboratory, the First Affiliated Hospital of Zhengzhou 
      University, Key Laboratory of Laboratory Medicine of Henan Province, Zhengzhou, 
      Henan, China.
FAU - Jiang, Zhiyun
AU  - Jiang Z
AD  - Department of Clinical Laboratory, the First Affiliated Hospital of Zhengzhou 
      University, Key Laboratory of Laboratory Medicine of Henan Province, Zhengzhou, 
      Henan, China.
FAU - Wu, Fan
AU  - Wu F
AD  - Department of Clinical Laboratory, the First Affiliated Hospital of Zhengzhou 
      University, Key Laboratory of Laboratory Medicine of Henan Province, Zhengzhou, 
      Henan, China.
FAU - Ping, Jiedan
AU  - Ping J
AD  - Department of Clinical Laboratory, the First Affiliated Hospital of Zhengzhou 
      University, Key Laboratory of Laboratory Medicine of Henan Province, Zhengzhou, 
      Henan, China.
FAU - Ming, Liang
AU  - Ming L
AD  - Department of Clinical Laboratory, the First Affiliated Hospital of Zhengzhou 
      University, Key Laboratory of Laboratory Medicine of Henan Province, Zhengzhou, 
      Henan, China - mingliangzzu1203@163.com.
LA  - eng
PT  - Journal Article
DEP - 20171009
PL  - Italy
TA  - Int Angiol
JT  - International angiology : a journal of the International Union of Angiology
JID - 8402693
RN  - 0 (Biomarkers)
RN  - 0 (Fibrin Fibrinogen Degradation Products)
RN  - 0 (MIRN27 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (fibrin fragment D)
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Computed Tomography Angiography
MH  - Female
MH  - Fibrin Fibrinogen Degradation Products/analysis
MH  - Humans
MH  - Male
MH  - MicroRNAs/*blood/genetics
MH  - Middle Aged
MH  - Pulmonary Embolism/*blood/*diagnostic imaging/genetics
MH  - ROC Curve
EDAT- 2017/10/11 06:00
MHDA- 2018/08/17 06:00
CRDT- 2017/10/10 06:00
PHST- 2017/10/11 06:00 [pubmed]
PHST- 2018/08/17 06:00 [medline]
PHST- 2017/10/10 06:00 [entrez]
AID - S0392-9590.17.03877-9 [pii]
AID - 10.23736/S0392-9590.17.03877-9 [doi]
PST - ppublish
SO  - Int Angiol. 2018 Feb;37(1):19-25. doi: 10.23736/S0392-9590.17.03877-9. Epub 2017 
      Oct 9.