PMID- 28992257
OWN - NLM
STAT- MEDLINE
DCOM- 20190805
LR  - 20220317
IS  - 1460-2385 (Electronic)
IS  - 0931-0509 (Print)
IS  - 0931-0509 (Linking)
VI  - 33
IP  - 3
DP  - 2018 Mar 1
TI  - Glomerular function in relation to circulating adhesion molecules and 
      inflammation markers in a general population.
PG  - 426-435
LID - 10.1093/ndt/gfx256 [doi]
AB  - BACKGROUND: Inflammation is a hallmark of chronic kidney disease (CKD) and 
      stimulates glomerular expression of vascular adhesion molecules (VCAMs). We 
      investigated in a general population whether estimated glomerular filtration rate 
      (eGFR) is associated with circulating adhesion molecules, inflammation markers or 
      both. METHODS: We measured serum levels of five adhesion molecules [VCAM-1, 
      intracellular adhesion molecule-1 (ICAM-1), P-selectin, E-selectin and monocyte 
      chemoattractant protein-1 (MCP-1)] and seven inflammation markers [C-reactive 
      protein (CRP), neutrophil gelatinase-associated lipocalin (NGAL), tumour necrosis 
      factor receptor 1 (TNF-R1), TNF-alpha, interleukin 6 (IL-6), IL-8 and vascular 
      endothelial growth factor] in 1338 randomly recruited people (50.8% women, mean 
      age 51.7 years, eGFR 79.9 mL/min/1.73 m2). RESULTS: In multivariable-adjusted 
      analyses, eGFR decreased (P </= 0.004) with higher VCAM-1 (association size 
      expressed in mL/min/1.73 m2 for a doubling of the marker, -2.99), MCP-1 (-1.19), 
      NGAL (-1.19), TNF receptor 1 (-2.78), TNF-alpha (-2.28) and IL-6 (-0.94). The odds 
      ratios of having eGFR <60 versus >/=60 mL/min/1.73 m2 (n = 138 versus 1200) were 
      significant (P </= 0.001) for VCAM-1 (1.77), MCP-1 (1.32), NGAL (1.26), TNF-R1 
      (1.49), TNF-alpha (1.45) and IL-6 (1.20). Compared with 24-h albuminuria, VCAM-1 
      increased (P <0.0001) the area under the curve from 0.57 to 0.65, MCP-1 to 0.67 
      and TNF-R1 to 0.79, but TNF-R1 outperformed both adhesion molecules (P < 0.0001). 
      CONCLUSIONS: In a general population, eGFR is inversely associated with 
      circulating adhesion molecules VCAM-1 and MCP-1 and several inflammation markers, 
      but inflammation markers, in particular TNF-R1 and TNF-alpha, identify patients with 
      eGFR <60 mL/min/1.73 m2 more accurately.
CI  - (c) The Author 2017. Published by Oxford University Press on behalf of ERA-EDTA.
FAU - Feng, Ying-Mei
AU  - Feng YM
AD  - Beijing Key Laboratory of Diabetes Prevention and Research, Department of 
      Endocrinology, Luhe Hospital, Capital Medical University, Beijing, China.
AD  - Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular 
      Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of 
      Leuven, Leuven, Belgium.
FAU - Thijs, Lutgarde
AU  - Thijs L
AD  - Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular 
      Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of 
      Leuven, Leuven, Belgium.
FAU - Zhang, Zhen-Yu
AU  - Zhang ZY
AD  - Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular 
      Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of 
      Leuven, Leuven, Belgium.
FAU - Yang, Wen-Yi
AU  - Yang WY
AD  - Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular 
      Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of 
      Leuven, Leuven, Belgium.
FAU - Huang, Qi-Fang
AU  - Huang QF
AD  - Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular 
      Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of 
      Leuven, Leuven, Belgium.
FAU - Wei, Fang-Fei
AU  - Wei FF
AD  - Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular 
      Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of 
      Leuven, Leuven, Belgium.
FAU - Kuznetsova, Tatiana
AU  - Kuznetsova T
AD  - Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular 
      Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of 
      Leuven, Leuven, Belgium.
FAU - Jennings, Ann-Marie
AU  - Jennings AM
AD  - Randox Laboratories, Crumlin, Northern Ireland.
FAU - Delles, Christian
AU  - Delles C
AD  - BHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK.
FAU - Lennox, Rachael
AU  - Lennox R
AD  - Randox Laboratories, Crumlin, Northern Ireland.
FAU - Verhamme, Peter
AU  - Verhamme P
AD  - Research Unit Molecular and Vascular Biology, KU Leuven Department of 
      Cardiovascular Sciences, University of Leuven, Leuven, Belgium.
FAU - Dominiczak, Anna
AU  - Dominiczak A
AD  - BHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK.
FAU - Staessen, Jan A
AU  - Staessen JA
AD  - Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular 
      Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of 
      Leuven, Leuven, Belgium.
AD  - R&D Group VitaK, Maastricht University, Maastricht, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
RN  - 0 (Biomarkers)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Inflammation Mediators)
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Belgium/epidemiology
MH  - Biomarkers/*blood
MH  - Cell Adhesion Molecules/*blood
MH  - Cross-Sectional Studies
MH  - Female
MH  - Follow-Up Studies
MH  - *Glomerular Filtration Rate
MH  - Humans
MH  - Inflammation/blood/*diagnosis/epidemiology
MH  - Inflammation Mediators/*blood
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Young Adult
PMC - PMC6018976
EDAT- 2017/10/11 06:00
MHDA- 2019/08/06 06:00
PMCR- 2017/08/23
CRDT- 2017/10/10 06:00
PHST- 2017/03/24 00:00 [received]
PHST- 2017/06/29 00:00 [accepted]
PHST- 2017/10/11 06:00 [pubmed]
PHST- 2019/08/06 06:00 [medline]
PHST- 2017/10/10 06:00 [entrez]
PHST- 2017/08/23 00:00 [pmc-release]
AID - 4093229 [pii]
AID - gfx256 [pii]
AID - 10.1093/ndt/gfx256 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2018 Mar 1;33(3):426-435. doi: 10.1093/ndt/gfx256.