PMID- 28992987
OWN - NLM
STAT- MEDLINE
DCOM- 20180103
LR  - 20210523
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Print)
IS  - 0197-4580 (Linking)
VI  - 60
DP  - 2017 Dec
TI  - The resting perfusion pattern associates with functional decline in type 2 
      diabetes.
PG  - 192-202
LID - S0197-4580(17)30297-X [pii]
LID - 10.1016/j.neurobiolaging.2017.09.004 [doi]
AB  - We investigated the relationships between cerebral blood flow (CBF), cognitive, 
      and mobility decline in type 2 diabetes mellitus (T2DM) over a 2-year period. 
      Seventy-three participants (41 T2DM and 32 controls) were evaluated using 
      volumetric CBF with arterial spin labeling perfusion magnetic resonance imaging 
      at baseline and at the 2-year follow-up. Regions with significant CBF differences 
      between T2DM participants and controls at baseline were detected using voxel-wise 
      analysis. Correlation analysis was performed to investigate the association 
      between regional CBF and cognitive or mobility performance over the 2-year span. 
      Compared to controls, participants with T2DM had decreased CBF in the 
      resting-state default mode, visual, and cerebellum networks. Greater decrease in 
      longitudinal CBF values at these regions over a 2-year span was associated with 
      worse gait, memory and executive functions, and higher baseline insulin 
      resistance and worse baseline cognitive performance. In T2DM, impairment of 
      resting regional perfusion is closely related to worse cognitive and mobility 
      performance. Insulin resistance may further contribute to regional perfusion 
      deficit in T2DM.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Dai, Weiying
AU  - Dai W
AD  - Department of Computer Science, State University of New York at Binghamton, 
      Binghamton, NY, USA. Electronic address: wdai@binghamton.edu.
FAU - Duan, Wenna
AU  - Duan W
AD  - Department of Computer Science, State University of New York at Binghamton, 
      Binghamton, NY, USA.
FAU - Alfaro, Freddy J
AU  - Alfaro FJ
AD  - Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston, MA, USA.
FAU - Gavrieli, Anna
AU  - Gavrieli A
AD  - Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston, MA, USA.
FAU - Kourtelidis, Fotini
AU  - Kourtelidis F
AD  - Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston, MA, USA.
FAU - Novak, Vera
AU  - Novak V
AD  - Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical 
      School, Boston, MA, USA.
LA  - eng
GR  - R01 DK103902/DK/NIDDK NIH HHS/United States
GR  - M01 RR001032/RR/NCRR NIH HHS/United States
GR  - R01 AG028076/AG/NIA NIH HHS/United States
GR  - R21 DK084463/DK/NIDDK NIH HHS/United States
GR  - UL1 RR025758/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20170914
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cerebrovascular Circulation/*physiology
MH  - Cognition/*physiology
MH  - Diabetes Mellitus, Type 2/*physiopathology/*psychology
MH  - Executive Function/physiology
MH  - Female
MH  - Gait/physiology
MH  - Humans
MH  - Insulin Resistance/physiology
MH  - Male
MH  - Memory/physiology
MH  - Middle Aged
MH  - Motor Activity/*physiology
MH  - Rest/*physiology
MH  - Time Factors
PMC - PMC5687828
MID - NIHMS911526
OTO - NOTNLM
OT  - Arterial spin labeling MRI
OT  - Cerebral blood flow
OT  - Cognitive impairment
OT  - Insulin resistance
OT  - Type 2 diabetes mellitus
OT  - Voxel-based analyses
COIS- Disclosure statement The authors do not have any conflicts of interest. 
      Appropriate approval and procedures were used concerning human subjects.
EDAT- 2017/10/11 06:00
MHDA- 2018/01/04 06:00
PMCR- 2018/12/01
CRDT- 2017/10/11 06:00
PHST- 2017/03/22 00:00 [received]
PHST- 2017/09/05 00:00 [revised]
PHST- 2017/09/06 00:00 [accepted]
PHST- 2017/10/11 06:00 [pubmed]
PHST- 2018/01/04 06:00 [medline]
PHST- 2017/10/11 06:00 [entrez]
PHST- 2018/12/01 00:00 [pmc-release]
AID - S0197-4580(17)30297-X [pii]
AID - 10.1016/j.neurobiolaging.2017.09.004 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2017 Dec;60:192-202. doi: 10.1016/j.neurobiolaging.2017.09.004. 
      Epub 2017 Sep 14.