PMID- 28993209
OWN - NLM
STAT- MEDLINE
DCOM- 20180702
LR  - 20180702
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 662
DP  - 2018 Jan 1
TI  - Rotigotine, a dopamine receptor agonist, increased BDNF protein levels in the rat 
      cortex and hippocampus.
PG  - 44-50
LID - S0304-3940(17)30824-8 [pii]
LID - 10.1016/j.neulet.2017.10.006 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) critically controls the fate and 
      function of the neuronal network and has received much attention as a target of 
      many brain diseases. Dopaminergic system dysfunction has also been implicated in 
      a variety of neuropsychiatric diseases. Rotigotine, a non-ergot dopamine receptor 
      agonist, is used in the treatment of Parkinson's disease and restless legs 
      syndrome. To investigate the effects of rotigotine on neuronal functions both in 
      vivo and in vitro, rats and primary cortical neurons were administered 
      rotigotine, and the mRNA and protein expression levels of BDNF, its receptor TrkB 
      and downstream signaling molecules, and synaptic proteins were determined. We 
      found that BDNF protein was increased in the cortex and hippocampus of rats after 
      7days of rotigotine treatment. In contrast, BDNF mRNAs were reduced 6h after 
      rotigotine treatment in cultured neurons presumably through the transient 
      suppression of neuronal activity. We identified differential expression of D1, 
      D2, and D3 receptors in the rat brain and cultured neurons. The observed increase 
      in the expression of BDNF protein in the cortex and hippocampus after subchronic 
      administration of rotigotine suggests that it may exert its medical effect in 
      part through improving BDNF function in the brain. In addition, our results 
      highlight the complex relationships between rotigotine and BDNF expression, which 
      depend on the brain region, time course, and dose of the drug.
CI  - Copyright (c) 2017 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Adachi, Naoki
AU  - Adachi N
AD  - Department of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan; Department of 
      Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin 
      University, Sanda City, Hyogo, Japan.
FAU - Yoshimura, Aya
AU  - Yoshimura A
AD  - Department of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan.
FAU - Chiba, Shuichi
AU  - Chiba S
AD  - Department of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan.
FAU - Ogawa, Shintaro
AU  - Ogawa S
AD  - Department of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan.
FAU - Kunugi, Hiroshi
AU  - Kunugi H
AD  - Department of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan. Electronic 
      address: hkunugi@ncnp.go.jp.
LA  - eng
PT  - Journal Article
DEP - 20171006
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dopamine Agonists)
RN  - 0 (Tetrahydronaphthalenes)
RN  - 0 (Thiophenes)
RN  - 63231-63-0 (RNA)
RN  - 87T4T8BO2E (rotigotine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cells, Cultured
MH  - Cerebellum/drug effects/metabolism
MH  - Cerebral Cortex/*drug effects/metabolism
MH  - Dopamine Agonists/*pharmacology
MH  - Hippocampus/*drug effects/metabolism
MH  - Male
MH  - Neurons/metabolism
MH  - Prefrontal Cortex/drug effects/metabolism
MH  - RNA/metabolism
MH  - Rats, Wistar
MH  - Tetrahydronaphthalenes/*pharmacology
MH  - Thiophenes/*pharmacology
OTO - NOTNLM
OT  - BDNF
OT  - Dopamine receptors
OT  - Rotigotine
OT  - Synaptic proteins
EDAT- 2017/10/11 06:00
MHDA- 2018/07/03 06:00
CRDT- 2017/10/11 06:00
PHST- 2017/04/14 00:00 [received]
PHST- 2017/10/03 00:00 [revised]
PHST- 2017/10/05 00:00 [accepted]
PHST- 2017/10/11 06:00 [pubmed]
PHST- 2018/07/03 06:00 [medline]
PHST- 2017/10/11 06:00 [entrez]
AID - S0304-3940(17)30824-8 [pii]
AID - 10.1016/j.neulet.2017.10.006 [doi]
PST - ppublish
SO  - Neurosci Lett. 2018 Jan 1;662:44-50. doi: 10.1016/j.neulet.2017.10.006. Epub 2017 
      Oct 6.