PMID- 28993605
OWN - NLM
STAT- MEDLINE
DCOM- 20180109
LR  - 20190609
IS  - 1941-5923 (Electronic)
IS  - 1941-5923 (Linking)
VI  - 18
DP  - 2017 Oct 10
TI  - A Case of Diffuse Alveolar Hemorrhage as a Possible Complication of Bivalirudin 
      Therapy.
PG  - 1081-1085
AB  - BACKGROUND Diffuse alveolar hemorrhage (DAH) is a rare but potentially fatal 
      complication of anticoagulant or antiplatelet therapy. Bivalirudin is a specific 
      and reversible direct thrombin inhibitor (DTI). CASE REPORT We report a case of 
      severe DAH, possibly related to bivalirudin use, in a 61-year-old patient 
      undergoing coronary intervention. The patient had presented with an 
      out-of-hospital cardiac arrest due to acute ST elevation myocardial infarction 
      (STEMI). During the coronary intervention, shortly after receiving bivalirudin, 
      the patient started having frank bleeding from the endotracheal tube and 
      developed hemodynamic compromise. Despite aggressive intervention and intensive 
      care, the patient died. CONCLUSIONS At this time, to our knowledge, there have 
      been no reports of DAH associated with the use of bivalirudin.
FAU - Latt, Htun
AU  - Latt H
AD  - Department of Internal Medicine, University of Nevada-Reno, School of Medicine, 
      Reno, NV, USA.
FAU - Aung, Sammy
AU  - Aung S
AD  - Department of Heart and Vascular Health, Renown Regional Medical Center, Reno, 
      NV, USA.
FAU - Kyaw, Kyaw
AU  - Kyaw K
AD  - Department of Heart and Vascular Health, Renown Regional Medical Center, Reno, 
      NV, USA.
FAU - Aung, Thein Tun
AU  - Aung TT
AD  - Department of Cardiology, Good Samaritan Hospital, Dayton, OH, USA.
FAU - Roongsritong, Chanwit
AU  - Roongsritong C
AD  - Department of Heart and Vascular Health, Renown Regional Medical Center, Reno, 
      NV, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20171010
PL  - United States
TA  - Am J Case Rep
JT  - The American journal of case reports
JID - 101489566
RN  - 0 (Antithrombins)
RN  - 0 (Hirudins)
RN  - 0 (Peptide Fragments)
RN  - 0 (Recombinant Proteins)
RN  - TN9BEX005G (bivalirudin)
SB  - IM
MH  - Antithrombins/*adverse effects
MH  - Fatal Outcome
MH  - Hemorrhage/*chemically induced
MH  - Hirudins/*adverse effects
MH  - Humans
MH  - Lung Diseases/*chemically induced
MH  - Male
MH  - Middle Aged
MH  - Out-of-Hospital Cardiac Arrest/therapy
MH  - Peptide Fragments/*adverse effects
MH  - Percutaneous Coronary Intervention
MH  - Pulmonary Alveoli
MH  - Recombinant Proteins/adverse effects
MH  - ST Elevation Myocardial Infarction/therapy
PMC - PMC5644459
COIS- Conflict of interest: None declared Conflict of interests None.
EDAT- 2017/10/11 06:00
MHDA- 2018/01/10 06:00
PMCR- 2017/10/10
CRDT- 2017/10/11 06:00
PHST- 2017/10/11 06:00 [entrez]
PHST- 2017/10/11 06:00 [pubmed]
PHST- 2018/01/10 06:00 [medline]
PHST- 2017/10/10 00:00 [pmc-release]
AID - 905721 [pii]
AID - 10.12659/ajcr.905721 [doi]
PST - epublish
SO  - Am J Case Rep. 2017 Oct 10;18:1081-1085. doi: 10.12659/ajcr.905721.