PMID- 28993936
OWN - NLM
STAT- MEDLINE
DCOM- 20180706
LR  - 20181113
IS  - 1432-1750 (Electronic)
IS  - 0341-2040 (Linking)
VI  - 195
IP  - 6
DP  - 2017 Dec
TI  - The Influence of Body Composition on Pulmonary Rehabilitation Outcomes in Chronic 
      Obstructive Pulmonary Disease Patients.
PG  - 729-738
LID - 10.1007/s00408-017-0053-y [doi]
AB  - INTRODUCTION: Alterations in body composition are commonly present in chronic 
      obstructive pulmonary disease (COPD). The hypothesis of this study is that COPD 
      patients would achieve clinical benefits after pulmonary rehabilitation (PR) 
      independent of muscle mass depletion or body weight. METHODS: We conducted a 
      retrospective cohort study using single-frequency bioelectrical impedance 
      analysis (BIA) for assessment of fat-free mass (FFM) depletion (muscle 
      depletion). Patients were stratified into three categories based on (1) obesity 
      BMI >/= 30 kg/m(2), (2) non-obesity BMI < 30 kg/m(2), and (3) combined cachexia 
      (BMI < 21 kg/m(2) and FFM index < 16 kg/m(2)) and muscle atrophy 
      (BMI >/= 21 kg/m(2) and FFMI < 16 kg/m(2)). PR outcomes were defined as the 
      improvement in exercise capacity (maximal exercise capacity, 6-min walk, constant 
      workload cycle exercise duration) and quality of life determined by Chronic 
      Respiratory Questionnaire after PR. RESULTS: We studied 72 patients with 
      available FFM measured by BIA. Patients were predominantly elderly man (N = 71; 
      98%), with a mean age of 72 years with COPD GOLD stage I-IV. The groups were 
      balanced in terms of age, comorbidities, baseline FEV1, exercise capacity, and 
      quality of life. The absolute changes in patients with muscle depletion or 
      obesity compared to those without muscle depletion or obesity were not 
      statistically different as was the percentage of patients reaching the minimal 
      clinically important difference (MCID) after PR. CONCLUSION: A comprehensive PR 
      program in COPD patients improved exercise tolerance and quality of life 
      independent of muscle mass depletion or obesity. Similarly, muscle depletion or 
      obesity had no effect on the percentage of patients achieving the MCID for 
      measures of quality of life and exercise tolerance after PR.
FAU - Tunsupon, Pichapong
AU  - Tunsupon P
AUID- ORCID: 0000-0003-2183-5210
AD  - Division of Pulmonary, Critical Care and Sleep Medicine Department of Medicine, 
      University of Florida, 1600 SW Archer Road, M415, PO BOX 100225, Gainesville, FL, 
      32610, USA. pichapong.tunsupon@medicine.ufl.edu.
FAU - Mador, M Jeffery
AU  - Mador MJ
AUID- ORCID: 0000-0003-2381-6339
AD  - Division of Pulmonary, Critical Care and Sleep Medicine Department of Medicine, 
      University at Buffalo State University of New York, 3495 Bailey Avenue, Buffalo, 
      NY, 14215, USA.
AD  - Western New York Veterans Administration Healthcare System, 3495 Bailey Avenue, 
      Buffalo, NY, 14215, USA.
LA  - eng
PT  - Journal Article
DEP - 20171009
PL  - United States
TA  - Lung
JT  - Lung
JID - 7701875
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Atrophy/complications/physiopathology
MH  - *Body Composition
MH  - Body Mass Index
MH  - Cachexia/complications/physiopathology
MH  - Electric Impedance
MH  - *Exercise Tolerance
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/*pathology
MH  - Obesity/complications/physiopathology
MH  - Pulmonary Disease, Chronic 
      Obstructive/complications/physiopathology/*rehabilitation
MH  - *Quality of Life
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Walk Test
OTO - NOTNLM
OT  - Bioelectrical impedance analysis
OT  - Body composition
OT  - Chronic obstructive pulmonary disease
OT  - Muscle mass depletion
OT  - Pulmonary rehabilitation
EDAT- 2017/10/11 06:00
MHDA- 2018/07/07 06:00
CRDT- 2017/10/11 06:00
PHST- 2017/06/05 00:00 [received]
PHST- 2017/09/11 00:00 [accepted]
PHST- 2017/10/11 06:00 [pubmed]
PHST- 2018/07/07 06:00 [medline]
PHST- 2017/10/11 06:00 [entrez]
AID - 10.1007/s00408-017-0053-y [pii]
AID - 10.1007/s00408-017-0053-y [doi]
PST - ppublish
SO  - Lung. 2017 Dec;195(6):729-738. doi: 10.1007/s00408-017-0053-y. Epub 2017 Oct 9.