PMID- 28994640
OWN - NLM
STAT- MEDLINE
DCOM- 20190909
LR  - 20190909
IS  - 1532-2750 (Electronic)
IS  - 1098-612X (Linking)
VI  - 20
IP  - 10
DP  - 2018 Oct
TI  - Serum symmetric dimethylarginine and creatinine in Birman cats compared with cats 
      of other breeds.
PG  - 905-912
LID - 10.1177/1098612X17734066 [doi]
AB  - Objectives The aim of this study was to assess whether, in contrast to serum 
      creatinine, which is higher in Birman cats than in other breeds, the serum 
      concentration of symmetric dimethylarginine (SDMA) is comparable in clinically 
      healthy Birmans and in the general feline population. This could allow, in this 
      breed, to better evaluate chronic kidney disease (CKD). Methods Serum creatinine 
      and SDMA were measured in clinically healthy Birmans (n = 50) and in cats of 
      other breeds (n = 46), and the results were statistically compared. A 
      breed-specific reference interval (RI) was established for Birmans and compared 
      with the RI for the general feline population (0.0-14.0 microg/dl). Results 
      Creatinine (1.58 +/- 0.36 mg/dl) and SDMA (12.2 +/- 2.8 microg/dl) were higher ( P 
      <0.001) in Birmans than in cats of other breeds (1.19 +/- 0.17 mg/dl; 10.3 +/- 2.5 
      microg/dl). In 20/50 Birman cats (40.0%) serum creatinine was higher than both the 
      non-breed-specific RI of our laboratory and the threshold recommended to classify 
      cats as IRIS stage 2 (1.6 mg/dl). The concentration of SDMA was higher than the 
      pre-existing RI in 10/50 Birmans (20.0%) and in four cats of other breeds (8.7%). 
      Among Birmans, the proportion of cats with SDMA >14 microg/dl was lower ( P <0.017) 
      than the proportion of cats with creatinine >1.60 mg/dl. However, the deviation 
      from the upper limit of the RI was lower than the analytical variability of the 
      method in 7/10 Birmans and in 4/4 cats of other breeds. The breed-specific RI 
      (3.5-18.7 microg/dl) overlapped with the pre-existing one. Conclusions and relevance 
      SDMA may be a better marker of CKD in Birman cats than creatinine when 
      non-breed-specific RIs are utilised. The coupled analysis of creatinine and SDMA 
      could help prevent errors in diagnosing and staging CKD in Birman cats.
FAU - Paltrinieri, Saverio
AU  - Paltrinieri S
AD  - 1 Department of Veterinary Medicine, University of Milan, Milan, Italy.
AD  - 2 Veterinary Teaching Hospital, University of Milan, Lodi, Italy.
FAU - Giraldi, Marco
AU  - Giraldi M
AD  - 1 Department of Veterinary Medicine, University of Milan, Milan, Italy.
AD  - 2 Veterinary Teaching Hospital, University of Milan, Lodi, Italy.
FAU - Prolo, Amanda
AU  - Prolo A
AD  - 1 Department of Veterinary Medicine, University of Milan, Milan, Italy.
FAU - Scarpa, Paola
AU  - Scarpa P
AD  - 1 Department of Veterinary Medicine, University of Milan, Milan, Italy.
AD  - 2 Veterinary Teaching Hospital, University of Milan, Lodi, Italy.
FAU - Piseddu, Eleonora
AU  - Piseddu E
AD  - 3 IDEXX Laboratories, Novara, Italy.
FAU - Beccati, Massimo
AU  - Beccati M
AD  - 4 ADDA, Veterinary Clinic, Capriate San Gervasio, Bergamo, Italy.
FAU - Graziani, Benedetta
AU  - Graziani B
AD  - 5 Di Gregoli-Tomei Veterinary Clinic, S Macario in Piano, Lucca, Italy.
FAU - Bo, Stefano
AU  - Bo S
AD  - 6 Bo-Ferro Veterinary Clinic, Turin, Italy.
LA  - eng
PT  - Journal Article
DEP - 20171010
PL  - England
TA  - J Feline Med Surg
JT  - Journal of feline medicine and surgery
JID - 100897329
RN  - 0 (Biomarkers)
RN  - 49787G1ULV (symmetric dimethylarginine)
RN  - 94ZLA3W45F (Arginine)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Animals
MH  - Arginine/*analogs & derivatives/blood
MH  - Biomarkers/blood
MH  - Cat Diseases/*blood
MH  - Cats
MH  - Creatinine/*blood
MH  - Female
MH  - Male
MH  - Pedigree
MH  - Reference Values
MH  - Renal Insufficiency, Chronic/blood/*veterinary
EDAT- 2017/10/11 06:00
MHDA- 2019/09/10 06:00
CRDT- 2017/10/11 06:00
PHST- 2017/10/11 06:00 [pubmed]
PHST- 2019/09/10 06:00 [medline]
PHST- 2017/10/11 06:00 [entrez]
AID - 10.1177/1098612X17734066 [doi]
PST - ppublish
SO  - J Feline Med Surg. 2018 Oct;20(10):905-912. doi: 10.1177/1098612X17734066. Epub 
      2017 Oct 10.