PMID- 2900458
OWN - NLM
STAT- MEDLINE
DCOM- 19880912
LR  - 20191210
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 43
IP  - 6
DP  - 1988
TI  - Dynorphin A [1-17] induces "reward" in rats in the place conditioning paradigm.
PG  - 503-8
AB  - Intracerebroventricular (i.c.v.) administration of dynorphin A [1-17] induced 
      significant place preference conditioning in male, Sprague-Dawley rats. Place 
      preferences were induced by 2.3 and 3.5 nmole, but not 1.2 nmole of dynorphin A. 
      Co-administration of naloxone, 27.5 nmole but not 5.5 nmole, antagonized the 
      reward response induced by 2.3 nmole of dynorphin A. Leu-enkephalin, 5 or 25 
      nmole, and dynorphin A [2-17], 2.3 or 3.5 nmole, had no effect in the place 
      conditioning paradigm.
FAU - Iwamoto, E T
AU  - Iwamoto ET
AD  - Department of Pharmacology, University of Kentucky College of Medicine, Lexington 
      40536.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 36B82AMQ7N (Naloxone)
RN  - 58822-25-6 (Enkephalin, Leucine)
RN  - 74913-18-1 (Dynorphins)
SB  - IM
MH  - Animals
MH  - Conditioning, Psychological/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Dynorphins/administration & dosage/*pharmacology
MH  - Enkephalin, Leucine/pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Naloxone/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - *Reward
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - 0024-3205(88)90151-8 [pii]
AID - 10.1016/0024-3205(88)90151-8 [doi]
PST - ppublish
SO  - Life Sci. 1988;43(6):503-8. doi: 10.1016/0024-3205(88)90151-8.