PMID- 2901358
OWN - NLM
STAT- MEDLINE
DCOM- 19881018
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 150
IP  - 3
DP  - 1988 Jun 10
TI  - Central effects of the potent and highly selective mu opioid antagonist 
      D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) in mice.
PG  - 355-60
AB  - The ability of the selective cyclic mu-opioid receptor antagonist, 
      D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP), to inhibit the acute and chronic 
      effects of morphine in vivo was studied in mice. Intracerebroventricular (i.c.v.) 
      administration of CTOP antagonized the analgesic effect of morphine in a 
      dose-dependent manner, as measured by the heat-irradiant (tail-flick) method. 
      CTOP was more effective than naloxone in inhibiting analgesia on a molar basis. 
      CTOP also antagonized the acute morphine-induced hypermotility. CTOP caused 
      withdrawal hypothermia and a loss of body weight in morphine-dependent animals. 
      After the development of morphine-induced chronic dependence, CTOP administered 
      i.c.v. caused a dose-dependent loss of body weight and hypothermia, and was about 
      10-400 times more potent than naloxone. CTOP administered alone to drugnaive mice 
      did not cause antinociception, changes in body weight or body temperature.
FAU - Gulya, K
AU  - Gulya K
AD  - Central Research Laboratory, Medical University, Szeged, Hungary.
FAU - Krivan, M
AU  - Krivan M
FAU - Nyolczas, N
AU  - Nyolczas N
FAU - Sarnyai, Z
AU  - Sarnyai Z
FAU - Kovacs, G L
AU  - Kovacs GL
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Receptors, Opioid)
RN  - 0 (Receptors, Opioid, mu)
RN  - 103429-31-8 
      (phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide)
RN  - 51110-01-1 (Somatostatin)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Animals
MH  - Body Temperature/drug effects
MH  - Body Weight/drug effects
MH  - Brain/*drug effects/physiology
MH  - Drug Tolerance
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Morphine/pharmacology
MH  - Morphine Dependence/psychology
MH  - Motor Activity/drug effects
MH  - Nociceptors/drug effects
MH  - Pain/physiopathology
MH  - Reaction Time/drug effects
MH  - Receptors, Opioid/*metabolism
MH  - Receptors, Opioid, mu
MH  - Sensory Thresholds/drug effects
MH  - Somatostatin/*analogs & derivatives/pharmacology
EDAT- 1988/06/10 00:00
MHDA- 1988/06/10 00:01
CRDT- 1988/06/10 00:00
PHST- 1988/06/10 00:00 [pubmed]
PHST- 1988/06/10 00:01 [medline]
PHST- 1988/06/10 00:00 [entrez]
AID - 0014-2999(88)90018-0 [pii]
AID - 10.1016/0014-2999(88)90018-0 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1988 Jun 10;150(3):355-60. doi: 10.1016/0014-2999(88)90018-0.