PMID- 2901437
OWN - NLM
STAT- MEDLINE
DCOM- 19881017
LR  - 20061115
IS  - 0021-9967 (Print)
IS  - 0021-9967 (Linking)
VI  - 272
IP  - 3
DP  - 1988 Jun 15
TI  - Neuropeptide- and neurotransmitter-related immunoreactivities in the developing 
      rat olfactory bulb.
PG  - 331-42
AB  - The development of neuropeptide and neurotransmitter-related immunoreactivities 
      in the rat olfactory bulb were investigated immunohistochemically by using 
      antisera raised against substance P (SP), cholecystokinin-8 (CCK), neurotensin 
      (NT), leucine-enkephalin or methionine-enkephalin-Arg6-Gly7-Leu8 (ENK), 
      somatostatin (SOM), neuropeptide Y (NPY) and tyrosine hydroxylase (TH). Results 
      obtained for the adult olfactory bulb confirmed previous observations, except for 
      SP-like immunoreactive (SP-IR) granule cells in the main olfactory bulb (MOB) and 
      NT-IR neurons around the modified glomerular complex (MGC) (Teicher et al., Brain 
      Res. 194:530-535, 1980). SP-, CCK- and NT-IR neurons were observed in the MOB of 
      the rat fetus. SP-IR neurons also appeared in the accessory olfactory bulb (AOB). 
      Among them, NT-IR neurons in the MOB and SP-IR neurons in the AOB were observed 
      on embryonic day 16. SP- and CCK-IR neurons in the MOB appeared on embryonic day 
      18. Most of these neurons were presumed to be projecting neurons. SOM-, NPY-, 
      ENK- and TH-IR neurons appeared in the newborn rats. The number and intensity of 
      immunostaining of these neurons continued to increase with age, producing the 
      adult pattern, except for NT-IR neurons in the MGC and SP-IR neurons in the 
      mitral cell layer of the AOB, which were more numerous and intensely stained in 
      young animals.
FAU - Matsutani, S
AU  - Matsutani S
AD  - Department of Anatomy (2nd Division), Osaka University Medical School, Japan.
FAU - Senba, E
AU  - Senba E
FAU - Tohyama, M
AU  - Tohyama M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
RN  - 0 (Neuropeptides)
RN  - 0 (Neurotransmitter Agents)
SB  - IM
MH  - Animals
MH  - Animals, Newborn/*growth & development/immunology
MH  - *Embryonic and Fetal Development
MH  - Immunohistochemistry
MH  - Neuropeptides/*immunology
MH  - Neurotransmitter Agents/*immunology
MH  - Olfactory Bulb/embryology/*immunology
MH  - Rats/embryology/growth & development/*immunology
MH  - Rats, Inbred Strains
MH  - Tissue Distribution
EDAT- 1988/06/15 00:00
MHDA- 1988/06/15 00:01
CRDT- 1988/06/15 00:00
PHST- 1988/06/15 00:00 [pubmed]
PHST- 1988/06/15 00:01 [medline]
PHST- 1988/06/15 00:00 [entrez]
AID - 10.1002/cne.902720304 [doi]
PST - ppublish
SO  - J Comp Neurol. 1988 Jun 15;272(3):331-42. doi: 10.1002/cne.902720304.