PMID- 2901488
OWN - NLM
STAT- MEDLINE
DCOM- 19881021
LR  - 20131121
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 246
IP  - 3
DP  - 1988 Sep
TI  - Differences in the stimulus properties of 3,4-methylenedioxyamphetamine and 3,4- 
      methylenedioxymethamphetamine in animals trained to discriminate hallucinogens 
      from saline.
PG  - 866-70
AB  - The stimulus properties of 3,4-methylenedioxyamphetamine (MDA), 
      3,4-methylenedioxymethamphetamine (MDMA) and several related compounds were 
      compared to those of (+)-lysergic acid diethylamide (LSD) and mescaline 
      (3,4,5-trimethoxyphenylethylamine) in a two-lever, water-reinforced, drug 
      discrimination task. In animals trained to discriminate LSD (0.08 mg/kg) from 
      saline (n = 8), LSD-like responding occurred during substitution (generalization) 
      tests with sufficiently high doses of (+/- )-2,5-dimethoxy-4-methylamphetamine, 
      LSD, mescaline, psilocybin and (-)-MDA; saline appropriate responding occurred 
      after (+)-MDA and both (+)- and (+)- and (-)-MDMA. In animals trained to 
      discriminate mescaline (10 mg/kg; n = 8), (-)-MDA, (+)-MDA, (-)-MDMA and (+)-MDMA 
      as well as (+/- )-2,5-dimethoxy-4-methylamphetamine, LSD, mescaline and 
      psilocybin mimicked the training drug. Neither (+)-amphetamine nor cocaine 
      produced mescaline-like responding; fenfluramine substituted partially for 
      mescaline but not LSD. Because all of the phenylisopropylamine enantiomers 
      mimicked the potent hallucinogen mescaline (10 mg/kg), these results do not 
      support suggestions that similarities in the behavioral effects of "designer" 
      drugs such as MDA and MDMA to those of hallucinogens are limited to (-)-MDA. They 
      also indicate that, although LSD and mescaline may be pharmacologically similar 
      (in other assays), these compounds do not have identical stimulus properties.
FAU - Callahan, P M
AU  - Callahan PM
AD  - Department of Psychology, University of South Carolina, Columbia.
FAU - Appel, J B
AU  - Appel JB
LA  - eng
GR  - R01 DA02543/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Amphetamines)
RN  - 0 (Hallucinogens)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 8NA5SWF92O (Lysergic Acid Diethylamide)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - RHO99102VC (Mescaline)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - Conditioning, Operant/drug effects
MH  - Discrimination Learning/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - *Hallucinogens
MH  - Lysergic Acid Diethylamide
MH  - Male
MH  - Mescaline
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1988/09/01 00:00
MHDA- 1988/09/01 00:01
CRDT- 1988/09/01 00:00
PHST- 1988/09/01 00:00 [pubmed]
PHST- 1988/09/01 00:01 [medline]
PHST- 1988/09/01 00:00 [entrez]
PST - ppublish
SO  - J Pharmacol Exp Ther. 1988 Sep;246(3):866-70.