PMID- 29016262 OWN - NLM STAT- MEDLINE DCOM- 20180706 LR - 20180706 IS - 1096-4673 (Electronic) IS - 0161-2840 (Linking) VI - 38 IP - 10 DP - 2017 Oct TI - Association of 5-HTTLPR Polymorphism with the Nursing Diagnoses and the Achievement of Nursing Outcomes in Patients with Major Depression. PG - 798-804 LID - 10.1080/01612840.2017.1364811 [doi] AB - The aim of this study is to investigate whether a 44-base-pair insertion/deletion polymorphism in the upstream regulatory region of the serotonin transporter gene (5-HTTLPR) is associated with the nursing diagnoses and the achievement of the desired nursing outcomes in inpatients with major depression. Thirty five patients were evaluated. The nursing diagnoses of risk for suicide and imbalanced nutrition are reported less often in homozygotes of the high-expressing gene (L(A)). Carriers of the low-expressing genes (L(G) or S) have a worse response to interventions which aim to increase low self-esteem, indicating that they may need more intensive care in order to achieve the desired outcome. Genetics in psychiatric nursing could help refine personalized care, however further studies with large sample sizes and multiple gene evaluations are needed. FAU - Prokofieva, Margarita AU - Prokofieva M AD - a Psychiatric Hospital of Attica , Fourth Department of Psychiatry , Athens , Greece. FAU - Karadima, Georgia AU - Karadima G AD - b National and Kapodistrian University of Athens , Medical School, Eginition Hospital , First Department of Neurology, Neurogenetics Unit, Athens , Greece. FAU - Koukia, Evmorfia AU - Koukia E AD - c National and Kapodistrian University of Athens , School of Health Sciences, Faculty of Nursing , Athens , Greece. FAU - Michou, Vassiliki AU - Michou V AD - d Locus Medicus SA , Department of Molecular Pathology and Genetics , Athens , Greece. FAU - Kyprianidou, Chrysoula AU - Kyprianidou C AD - d Locus Medicus SA , Department of Molecular Pathology and Genetics , Athens , Greece. FAU - Papageorgiou, Chrysovalantis V AU - Papageorgiou CV AD - d Locus Medicus SA , Department of Molecular Pathology and Genetics , Athens , Greece. FAU - Alexiadis, Evangelos AU - Alexiadis E AD - e BioAnalytica Genotype SA , Department of Molecular Biology and Genetics , Athens , Greece. FAU - Constantoulakis, Pantelis AU - Constantoulakis P AD - e BioAnalytica Genotype SA , Department of Molecular Biology and Genetics , Athens , Greece. FAU - Dikeos, Dimitris AU - Dikeos D AD - f National and Kapodistrian University of Athens , Medical School, Eginition Hospital, First Department of Psychiatry , Athens , Greece. LA - eng PT - Journal Article PL - England TA - Issues Ment Health Nurs JT - Issues in mental health nursing JID - 7907126 RN - 0 (SLC6A4 protein, human) RN - 0 (Serotonin Plasma Membrane Transport Proteins) MH - Adult MH - Depressive Disorder, Major/diagnosis/*genetics/therapy MH - Female MH - Hospitalization MH - Humans MH - Male MH - Middle Aged MH - *Nursing Diagnosis MH - *Polymorphism, Genetic MH - Serotonin Plasma Membrane Transport Proteins/*genetics MH - Treatment Outcome EDAT- 2017/10/11 06:00 MHDA- 2018/07/07 06:00 CRDT- 2017/10/11 06:00 PHST- 2017/10/11 06:00 [entrez] PHST- 2017/10/11 06:00 [pubmed] PHST- 2018/07/07 06:00 [medline] AID - 10.1080/01612840.2017.1364811 [doi] PST - ppublish SO - Issues Ment Health Nurs. 2017 Oct;38(10):798-804. doi: 10.1080/01612840.2017.1364811.