PMID- 29016288
OWN - NLM
STAT- MEDLINE
DCOM- 20171130
LR  - 20181113
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 97
IP  - 5
DP  - 2017 Nov
TI  - Efficacy and Safety of Liposomal Amphotericin B for Visceral Leishmaniasis in 
      Children and Adolescents at a Tertiary Care Center in Bihar, India.
PG  - 1498-1502
LID - 10.4269/ajtmh.17-0094 [doi]
AB  - Liposomal amphotericin B is being used increasingly to reduce the burden of 
      kala-azar from the Indian subcontinent. There are studies which have evaluated 
      efficacy and safety of liposomal amphotericin B for visceral leishmaniasis in all 
      age groups. However, the only study that specifically addressed treatment of 
      childhood visceral leishmaniasis did not include all ages or document renal and 
      liver function. We, therefore, felt it was important to reassess the efficacy and 
      safety of single dose liposomal amphotericin B in children and adolescents. A 
      total of 100 parasitologically confirmed visceral leishmaniasis patients aged < 
      15 years were included in this study. Participants consisted of 65 males and 35 
      females. All of them had come from the endemic region of Bihar. They were 
      administered one dose intravenous infusion of liposomal amphptericin B at 10 
      mg/kg body weight. Efficacy was assessed as initial and final cure at 1 and 6 
      months, respectively, and safety of all participants who were recruited in the 
      study. The initial and final cure rate by per protocol analysis was 100% and 
      97.9%, respectively. Chills and rigors were the most commonly occurring adverse 
      events (AEs). All the AEs were mild in intensity, and none of the patients 
      experienced any serious AEs. No patients developed nephrotoxicity. Our finding 
      indicates that liposomal amphotericin B at 10 mg/kg body weight is safe and 
      effective in children. Results of our study support the use of single dose 
      liposomal amphotericin B in all age group populations for elimination of 
      kala-azar from the Indian subcontinent.
FAU - Pandey, Krishna
AU  - Pandey K
AD  - Department of Clinical Medicine, Rajendra Memorial Research Institute of Medical 
      Sciences (Indian, Council of Medical Research), Patna, Bihar, India.
FAU - Pal, Biplab
AU  - Pal B
AD  - Department of Pharmacy Practice, National Institute of Pharmaceutical Education 
      and Research, Hajipur, Bihar, India.
FAU - Siddiqui, Niyamat Ali
AU  - Siddiqui NA
AD  - Department of Biostatistics, Rajendra Memorial Research Institute of Medical 
      Sciences (Indian Council, of Medical Research), Patna, Bihar, India.
FAU - Rabi Das, Vidya Nand
AU  - Rabi Das VN
AD  - Department of Clinical Medicine, Rajendra Memorial Research Institute of Medical 
      Sciences (Indian, Council of Medical Research), Patna, Bihar, India.
FAU - Murti, Krishna
AU  - Murti K
AD  - Department of Pharmacy Practice, National Institute of Pharmaceutical Education 
      and Research, Hajipur, Bihar, India.
FAU - Lal, Chandra Shekhar
AU  - Lal CS
AD  - Department of Biochemistry, Rajendra Memorial Research Institute of Medical 
      Sciences, (Indian Council of Medical Research), Patna, Bihar, India.
FAU - Verma, Neena
AU  - Verma N
AD  - Department of Pathology, Rajendra Memorial Research Institute of Medical Sciences 
      (Indian Council of, Medical Research), Patna, Bihar, India.
FAU - Babu, Rajendra
AU  - Babu R
AD  - Department of Pharmacy Practice, National Institute of Pharmaceutical Education 
      and Research, Hajipur, Bihar, India.
FAU - Ali, Vahab
AU  - Ali V
AD  - Department of Biochemistry, Rajendra Memorial Research Institute of Medical 
      Sciences, (Indian Council of Medical Research), Patna, Bihar, India.
FAU - Kumar, Rakesh
AU  - Kumar R
AD  - Department of Clinical Medicine, Rajendra Memorial Research Institute of Medical 
      Sciences (Indian, Council of Medical Research), Patna, Bihar, India.
FAU - Das, Pradeep
AU  - Das P
AD  - Department of Molecular Biology, Rajendra Memorial Research Institute of Medical 
      Sciences (Indian, Council of Medical Research), Patna, Bihar, India.
LA  - eng
PT  - Journal Article
DEP - 20171010
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Antiprotozoal Agents)
RN  - 0 (liposomal amphotericin B)
RN  - 7XU7A7DROE (Amphotericin B)
SB  - IM
MH  - Adolescent
MH  - Amphotericin B/*therapeutic use
MH  - Antiprotozoal Agents/*therapeutic use
MH  - Child
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - India
MH  - Infusions, Intravenous
MH  - Leishmaniasis, Visceral/*drug therapy
MH  - Male
MH  - Prospective Studies
MH  - Tertiary Care Centers
PMC - PMC5817748
EDAT- 2017/10/11 06:00
MHDA- 2017/12/01 06:00
PMCR- 2018/11/08
CRDT- 2017/10/11 06:00
PHST- 2017/10/11 06:00 [pubmed]
PHST- 2017/12/01 06:00 [medline]
PHST- 2017/10/11 06:00 [entrez]
PHST- 2018/11/08 00:00 [pmc-release]
AID - tpmd170094 [pii]
AID - 10.4269/ajtmh.17-0094 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2017 Nov;97(5):1498-1502. doi: 10.4269/ajtmh.17-0094. Epub 
      2017 Oct 10.