PMID- 29016339
OWN - NLM
STAT- MEDLINE
DCOM- 20171130
LR  - 20181113
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 97
IP  - 5
DP  - 2017 Nov
TI  - Synthetic Antigens Derived from Plasmodium falciparum Sporozoite, Liver, and 
      Blood Stages: Naturally Acquired Immune Response and Human Leukocyte Antigen 
      Associations in Individuals Living in a Brazilian Endemic Area.
PG  - 1581-1592
LID - 10.4269/ajtmh.17-0359 [doi]
AB  - Peptide vaccine strategies using Plasmodium-derived antigens have emerged as an 
      attractive approach against malaria. However, relatively few studies have been 
      conducted with malaria-exposed populations from non-African countries. Herein, 
      the seroepidemiological profile against Plasmodium falciparum of naturally 
      exposed individuals from a Brazilian malaria-endemic area against synthetic 
      peptides derived from vaccine candidates circumsporozoite protein (CSP), liver 
      stage antigen-1 (LSA-1), erythrocyte binding antigen-175 (EBA-175), and merozoite 
      surface protein-3 (MSP-3) was investigated. Moreover, human leukocyte antigen 
      (HLA)-DRB1* and HLA-DQB1* were evaluated to characterize genetic modulation of 
      humoral responsiveness to these antigens. The study was performed using blood 
      samples from 187 individuals living in rural malaria-endemic villages situated 
      near Porto Velho, Rondonia State. Specific IgG and IgM antibodies and IgG 
      subclasses were detected by enzyme-linked immunosorbent assay, and HLA-DRB1* and 
      HLA-DQB1* low-resolution typing was performed by PCR-SSP. All four synthetic 
      peptides were broadly recognized by naturally acquired antibodies. Regarding the 
      IgG subclass profile, only CSP induced IgG1 and IgG3 antibodies, which is an 
      important fact given that the acquisition of protective immunity appears to be 
      associated with the cytophilicity of IgG1 and IgG3 antibodies. HLA-DRB1*11 and 
      HLA-DQB1*7 had the lowest odds of responding to EBA-175. Our results showed that 
      CSP, LSA-1, EBA, and MSP-3 are immunogenic in natural conditions of exposure and 
      that anti-EBA antibody responses appear to be modulated by HLA class II antigens.
FAU - Pratt-Riccio, Lilian Rose
AU  - Pratt-Riccio LR
AD  - Laboratorio de Pesquisa em Malaria, Instituto Oswaldo Cruz, Fiocruz, Rio de 
      Janeiro, Brazil.
FAU - De Souza Perce-Da-Silva, Daiana
AU  - De Souza Perce-Da-Silva D
AD  - Laboratorio de Imunologia Clinica, Instituto Oswaldo Cruz, Fiocruz, Rio de 
      Janeiro, Brazil.
FAU - Da Costa Lima-Junior, Josue
AU  - Da Costa Lima-Junior J
AD  - Laboratorio de Imunoparasitologia, Instituto Oswaldo Cruz, Fiocruz, Rio de 
      Janeiro, Brazil.
FAU - Pratt Riccio, Evelyn Kety
AU  - Pratt Riccio EK
AD  - Laboratorio de Pesquisa em Malaria, Instituto Oswaldo Cruz, Fiocruz, Rio de 
      Janeiro, Brazil.
FAU - Ribeiro-Alves, Marcelo
AU  - Ribeiro-Alves M
AD  - Laboratorio de Pesquisa Clinica em DST/AIDS, Instituto Nacional de Infectologia 
      Evandro Chagas, Fiocruz, Rio de Janeiro, Brazil.
FAU - Santos, Fatima
AU  - Santos F
AD  - Laboratorio Central de Saude Publica (LACEN), Rondonia, Brazil.
FAU - Arruda, Mercia
AU  - Arruda M
AD  - Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhaes, Fiocruz, Recife, 
      Brazil.
FAU - Camus, Daniel
AU  - Camus D
AD  - Service de Parasitologie-Mycologie, Faculte de Medecine, Lille, France.
FAU - Druilhe, Pierre
AU  - Druilhe P
AD  - VAC4ALL, Paris, France.
FAU - Oliveira-Ferreira, Joseli
AU  - Oliveira-Ferreira J
AD  - Laboratorio de Imunoparasitologia, Instituto Oswaldo Cruz, Fiocruz, Rio de 
      Janeiro, Brazil.
FAU - Daniel-Ribeiro, Claudio Tadeu
AU  - Daniel-Ribeiro CT
AD  - Laboratorio de Pesquisa em Malaria, Instituto Oswaldo Cruz, Fiocruz, Rio de 
      Janeiro, Brazil.
FAU - Banic, Dalma Maria
AU  - Banic DM
AD  - Laboratorio de Imunologia Clinica, Instituto Oswaldo Cruz, Fiocruz, Rio de 
      Janeiro, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20171010
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Antibodies, Protozoan)
RN  - 0 (Antigens, Protozoan)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Malaria Vaccines)
RN  - 0 (Protozoan Proteins)
RN  - 0 (circumsporozoite protein, Protozoan)
RN  - 0 (liver stage-specific antigen, Plasmodium)
RN  - 0 (merozoite surface protein 3, Plasmodium)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Protozoan/blood
MH  - Antigens, Protozoan/*immunology
MH  - Brazil/epidemiology
MH  - Female
MH  - HLA-DQ beta-Chains/*genetics
MH  - Humans
MH  - *Immunity, Humoral
MH  - Immunoglobulin G/blood
MH  - Immunoglobulin M/blood
MH  - Malaria Vaccines/*immunology
MH  - Malaria, Falciparum/epidemiology/*immunology
MH  - Male
MH  - Middle Aged
MH  - Plasmodium falciparum/immunology
MH  - Protozoan Proteins/immunology
MH  - Sporozoites/immunology
MH  - Young Adult
PMC - PMC5817778
EDAT- 2017/10/11 06:00
MHDA- 2017/12/01 06:00
PMCR- 2018/11/08
CRDT- 2017/10/11 06:00
PHST- 2017/10/11 06:00 [pubmed]
PHST- 2017/12/01 06:00 [medline]
PHST- 2017/10/11 06:00 [entrez]
PHST- 2018/11/08 00:00 [pmc-release]
AID - tpmd170359 [pii]
AID - 10.4269/ajtmh.17-0359 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2017 Nov;97(5):1581-1592. doi: 10.4269/ajtmh.17-0359. Epub 
      2017 Oct 10.