PMID- 29016710
OWN - NLM
STAT- MEDLINE
DCOM- 20180618
LR  - 20240306
IS  - 1464-3502 (Electronic)
IS  - 0735-0414 (Print)
IS  - 0735-0414 (Linking)
VI  - 52
IP  - 6
DP  - 2017 Nov 1
TI  - Preliminary Evidence for Disrupted Nucleus Accumbens Reactivity and Connectivity 
      to Reward in Binge Drinkers.
PG  - 647-654
LID - 10.1093/alcalc/agx062 [doi]
AB  - AIMS: Dysfunctional brain reward circuitry, particularly in the nucleus accumbens 
      (NAcc), has been proposed as a risk factor for alcohol use disorder (AUD). This 
      risk factor may be evident in binge drinkers (BD), who are at high risk for 
      developing AUD. We examined whole-brain and NAcc reactivity to reward in BD 
      compared to non-binge drinkers (NBD), hypothesizing that groups would differ in 
      their neural reactivity and connectivity. METHODS: Healthy BD (N = 27) and NBD (N 
      = 23)-none meeting AUD criteria-completed a reward-guessing game, the 'Doors' 
      task, during functional magnetic resonance imaging. We conducted an exploratory 
      whole-brain search for group differences, but given our a priori hypotheses, we 
      also extracted activation from the NAcc to examine reactivity during reward (Win 
      > Loss) and functional connectivity (FC) to the prefrontal cortex. RESULTS: 
      Compared to NBD, BD exhibited greater activation in both the right and left NAcc 
      during reward relative to loss. Additionally, NBD drinkers exhibited positive FC 
      between the NAcc and dorsal anterior cingulate (dACC) whereas the BD showed 
      negative FC between these regions. Furthermore, less NAcc-dACC FC was related to 
      more past month alcohol use. CONCLUSIONS: Our results provide preliminary 
      evidence that BD exhibit greater NAcc activation during reward receipt relative 
      to loss. This is consistent with the broader AUD literature and suggests aberrant 
      neural reactivity may precede disorder onset. In addition, BD exhibited less 
      NAcc-dACC FC, perhaps reflecting deficient regulation of activation to rewards 
      compared to losses. This profile of reward brain circuitry could represent neural 
      correlates of vulnerability for AUD. SHORT SUMMARY: Healthy binge drinkers, at 
      risk for alcohol use disorder, exhibited greater nucleus accumbens activation 
      during reward relative to loss. In addition, binge drinkers exhibited reduced 
      connectivity between the nucleus accumbens and dorsal anterior cingulate, which 
      was associated with more past month alcohol use.
CI  - (c) The Author 2017. Medical Council on Alcohol and Oxford University Press. All 
      rights reserved.
FAU - Crane, Natania A
AU  - Crane NA
AD  - Department of Psychiatry, University of Illinois at Chicago, 1747 W Roosevelt Rd 
      Chicago, IL 60608, USA.
FAU - Gorka, Stephanie M
AU  - Gorka SM
AD  - Department of Psychiatry, University of Illinois at Chicago, 1747 W Roosevelt Rd 
      Chicago, IL 60608, USA.
FAU - Weafer, Jessica
AU  - Weafer J
AD  - Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 
      S Maryland Ave Chicago, IL 60637, USA.
FAU - Langenecker, Scott A
AU  - Langenecker SA
AD  - Department of Psychiatry, University of Illinois at Chicago, 1747 W Roosevelt Rd 
      Chicago, IL 60608, USA.
FAU - de Wit, Harriet
AU  - de Wit H
AD  - Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 
      S Maryland Ave Chicago, IL 60637, USA.
FAU - Phan, K Luan
AU  - Phan KL
AD  - Department of Psychiatry, University of Illinois at Chicago, 1747 W Roosevelt Rd 
      Chicago, IL 60608, USA.
AD  - Mental Health Service Line, Jesse Brown VA Medical Center, 820 S Damen Ave 
      Chicago, IL 60612, USA.
LA  - eng
GR  - CZH/4/645/CSO_/Chief Scientist Office/United Kingdom
GR  - R21 DA037642/DA/NIDA NIH HHS/United States
GR  - K23 AA025111/AA/NIAAA NIH HHS/United States
GR  - K01 AA024519/AA/NIAAA NIH HHS/United States
GR  - R01 DA002812/DA/NIDA NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Alcohol Alcohol
JT  - Alcohol and alcoholism (Oxford, Oxfordshire)
JID - 8310684
SB  - IM
MH  - Adult
MH  - Binge Drinking/*diagnostic imaging/psychology
MH  - Female
MH  - Gyrus Cinguli/*diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Nerve Net/*diagnostic imaging
MH  - Neural Pathways/diagnostic imaging
MH  - Nucleus Accumbens/*diagnostic imaging
MH  - *Reward
MH  - Young Adult
PMC - PMC5860287
EDAT- 2017/10/11 06:00
MHDA- 2018/06/19 06:00
PMCR- 2018/11/01
CRDT- 2017/10/11 06:00
PHST- 2017/03/29 00:00 [received]
PHST- 2017/08/23 00:00 [accepted]
PHST- 2017/10/11 06:00 [pubmed]
PHST- 2018/06/19 06:00 [medline]
PHST- 2017/10/11 06:00 [entrez]
PHST- 2018/11/01 00:00 [pmc-release]
AID - 4107889 [pii]
AID - agx062 [pii]
AID - 10.1093/alcalc/agx062 [doi]
PST - ppublish
SO  - Alcohol Alcohol. 2017 Nov 1;52(6):647-654. doi: 10.1093/alcalc/agx062.