PMID- 29017139
OWN - NLM
STAT- MEDLINE
DCOM- 20180508
LR  - 20181202
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 258
DP  - 2017 Dec
TI  - Do serum BDNF levels vary in self-harm behavior among adolescents and are they 
      correlated with traumatic experiences?
PG  - 130-135
LID - S0165-1781(17)30708-4 [pii]
LID - 10.1016/j.psychres.2017.09.069 [doi]
AB  - The aim of this study was to compare serum brain-derived neurotrophic factor 
      (BDNF) levels between adolescents that harm themselves, those that receive 
      psychiatric treatment but do not harm themselves, healthy adolescents, and 
      childhood traumas and to investigate the relationship between traumatic 
      experiences and serum BDNF levels. The cases were divided into two groups of 40 
      adolescents exhibiting self-harm behavior (self-harm/diagnosed group) and 30 
      adolescents receiving psychiatric treatment but not exhibiting self-harm 
      behaviors (non self-harm/diagnosed group). The control group (healthy control 
      group) consisted of 35 healthy adolescents with no psychiatric disorders or 
      self-harm behaviors. The adolescents were asked to fill in the Inventory of 
      Statements About Self Injury (ISAS) and Childhood Trauma Questionnaire (CTQ). For 
      BDNF measurement, blood samples were taken from the cases and controls. The serum 
      BDNF level of self-harming adolescents who used the self-cutting method was 
      significantly lower than that of other groups, and serum BDNF levels decreased 
      with the increase in the emotional neglect and abuse severity of self-harming 
      adolescents during childhood. In our study, serum BDNF levels decreased with the 
      increase in emotional abuse in self-harming adolescents. This finding may 
      indicate that neuroplasticity can be affected by a negative emotional environment 
      during the early period.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Kavurma, Canem
AU  - Kavurma C
AD  - Department of Child and Adolescent Psychiatry, Faculty of Medicine, Dokuz Eylul 
      University, Izmir, Turkey.
FAU - Varol Tas, Fatma
AU  - Varol Tas F
AD  - Department of Child and Adolescent Psychiatry, Faculty of Medicine, Dokuz Eylul 
      University, Izmir, Turkey.
FAU - Serim Demirgoren, Burcu
AU  - Serim Demirgoren B
AD  - Department of Child and Adolescent Psychiatry, Faculty of Medicine, Dokuz Eylul 
      University, Izmir, Turkey. Electronic address: burcuserim@hotmail.com.
FAU - Demirci, Ferhat
AU  - Demirci F
AD  - MD, Department of Biochemistry, Faculty of Medicine, Dokuz Eylul University, 
      Izmir, Turkey.
FAU - Akan, Pinar
AU  - Akan P
AD  - MD, Department of Biochemistry, Faculty of Medicine, Dokuz Eylul University, 
      Izmir, Turkey.
FAU - Eyuboglu, Damla
AU  - Eyuboglu D
AD  - Department of Child and Adolescent Psychiatry, Faculty of Medicine, Dokuz Eylul 
      University, Izmir, Turkey.
FAU - Guvenir, Taner
AU  - Guvenir T
AD  - Department of Child and Adolescent Psychiatry, Faculty of Medicine, Dokuz Eylul 
      University, Izmir, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20170928
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Child
MH  - Child Abuse/psychology/statistics & numerical data
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Male
MH  - Psychological Trauma/*blood/psychology
MH  - Self Report
MH  - Self-Injurious Behavior/*blood/psychology
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - BDNF
OT  - Childhood trauma
OT  - Neuroplasticity
OT  - Self-harm
EDAT- 2017/10/11 06:00
MHDA- 2018/05/09 06:00
CRDT- 2017/10/11 06:00
PHST- 2017/04/27 00:00 [received]
PHST- 2017/09/05 00:00 [revised]
PHST- 2017/09/24 00:00 [accepted]
PHST- 2017/10/11 06:00 [pubmed]
PHST- 2018/05/09 06:00 [medline]
PHST- 2017/10/11 06:00 [entrez]
AID - S0165-1781(17)30708-4 [pii]
AID - 10.1016/j.psychres.2017.09.069 [doi]
PST - ppublish
SO  - Psychiatry Res. 2017 Dec;258:130-135. doi: 10.1016/j.psychres.2017.09.069. Epub 
      2017 Sep 28.