PMID- 29017372
OWN - NLM
STAT- MEDLINE
DCOM- 20190515
LR  - 20190515
IS  - 1478-6427 (Electronic)
IS  - 1478-6419 (Linking)
VI  - 32
IP  - 24
DP  - 2018 Dec
TI  - The antidepressant-like activity of ellagic acid and its effect on hippocampal 
      brain derived neurotrophic factor levels in mouse depression models.
PG  - 2932-2935
LID - 10.1080/14786419.2017.1385021 [doi]
AB  - The aim of present study was to evaluate the antidepressant-like activity of 
      ellagic acid (EA) in mice-forced swim test (FST) and tail suspension test (TST) 
      and the possible role of brain-derived neurotrophic factor (BDNF) in EA's 
      antidepressant-like effect. We found that EA and sertraline did not affect the 
      spontaneous locomotor activity of mice. EA produced statistically significant 
      decrease in immobility time as compared to vehicle group in TST. EA at 1 and 
      5 mg/kg doses did not produce any significant effect in immobility time as 
      compared to vehicle group in FST. But EA produced significantly reduced 
      immobility time at 2.5 mg/kg dose. EA treatment increased hippocampal BDNF level. 
      This study demonstrates that EA is able to produce antidepressant-like effect in 
      both TST and FST in mice. Moreover, the antidepressant-like effects of EA seems 
      to be mediated by increased BDNF level in mice hippocampus.
FAU - Bedel, Hatice Asli
AU  - Bedel HA
AD  - a Faculty of Medicine, Department of Pharmacology , Akdeniz University , Antalya 
      , Turkey.
FAU - Kencebay Manas, Ceren
AU  - Kencebay Manas C
AD  - b Faculty of Medicine, Department of Biophysics , Akdeniz University , Antalya , 
      Turkey.
FAU - Ozbey, Gul
AU  - Ozbey G
AD  - a Faculty of Medicine, Department of Pharmacology , Akdeniz University , Antalya 
      , Turkey.
FAU - Usta, Coskun
AU  - Usta C
AD  - a Faculty of Medicine, Department of Pharmacology , Akdeniz University , Antalya 
      , Turkey.
LA  - eng
PT  - Journal Article
DEP - 20171011
PL  - England
TA  - Nat Prod Res
JT  - Natural product research
JID - 101167924
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 19YRN3ZS9P (Ellagic Acid)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*chemistry/pharmacology
MH  - Brain-Derived Neurotrophic Factor/*drug effects/pharmacology
MH  - Depression/drug therapy/etiology
MH  - Disease Models, Animal
MH  - Ellagic Acid/*pharmacology
MH  - Hindlimb Suspension
MH  - Hippocampus/*chemistry
MH  - Mice
MH  - Swimming
OTO - NOTNLM
OT  - BDNF
OT  - Ellagic acid
OT  - depression
EDAT- 2017/10/12 06:00
MHDA- 2019/05/16 06:00
CRDT- 2017/10/12 06:00
PHST- 2017/10/12 06:00 [pubmed]
PHST- 2019/05/16 06:00 [medline]
PHST- 2017/10/12 06:00 [entrez]
AID - 10.1080/14786419.2017.1385021 [doi]
PST - ppublish
SO  - Nat Prod Res. 2018 Dec;32(24):2932-2935. doi: 10.1080/14786419.2017.1385021. Epub 
      2017 Oct 11.