PMID- 29017963
OWN - NLM
STAT- MEDLINE
DCOM- 20171124
LR  - 20220330
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 641
DP  - 2018 Jan 30
TI  - The role of CXCL12 in tumor microenvironment.
PG  - 105-110
LID - S0378-1119(17)30828-4 [pii]
LID - 10.1016/j.gene.2017.10.015 [doi]
AB  - The chemokine ligand C-X-C motif chemokine ligand 12 (CXCL12) is a kind of small 
      molecules of cytokines that widely expressed in diversified tissues. Recent 
      evidence suggests that CXCL12 plays an important role in the communication of 
      tumor cells with their surrounding microenvironment. The interaction of CXCL12 
      and its receptors subsequently excite the downstream signaling pathways to affect 
      tumor angiogenesis, tumor cell proliferation and chemoresistance, and thus 
      represents a potential target for cancer therapy. Outpouring molecules targeting 
      CXCL12/CXCR4 axis in tumor microenvironment combined with traditional 
      chemotherapy have drawn more and more attentions, which will be a promising 
      method in anti-cancer therapies. Our review focuses on these roles of CXCL12 and 
      summarizes strategies for treating cancer by disrupting this interaction with 
      special emphasis on the CXCR4/CXCL12 axis.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Meng, Wenfang
AU  - Meng W
AD  - Division of Medical Genetics and Genomics, The Children's Hospital, Zhejiang 
      University School of Medicine, Hangzhou, Zhejiang, China; Institute of Genetics, 
      Zhejiang University, Hangzhou, Zhejiang, China.
FAU - Xue, Shihang
AU  - Xue S
AD  - Ningbo No.4 People's Hospital, Ningbo, Zhejiang, China.
FAU - Chen, Ye
AU  - Chen Y
AD  - Division of Medical Genetics and Genomics, The Children's Hospital, Zhejiang 
      University School of Medicine, Hangzhou, Zhejiang, China; Institute of Genetics, 
      Zhejiang University, Hangzhou, Zhejiang, China. Electronic address: 
      yechency@zju.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171007
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (Antineoplastic Agents)
RN  - 0 (CXCL12 protein, human)
RN  - 0 (CXCR4 protein, human)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Receptors, CXCR4)
SB  - IM
MH  - Antineoplastic Agents/therapeutic use
MH  - Cell Adhesion/physiology
MH  - Cell Communication/*physiology
MH  - Chemokine CXCL12/*metabolism
MH  - Humans
MH  - Neoplasm Metastasis/pathology
MH  - Neoplasms/drug therapy/genetics/*pathology
MH  - Neovascularization, Pathologic/*pathology
MH  - Receptors, CXCR4/*metabolism
MH  - Tumor Microenvironment/genetics/*physiology
OTO - NOTNLM
OT  - CXCL12
OT  - Tumor cell
OT  - Tumor microenvironment
EDAT- 2017/10/12 06:00
MHDA- 2017/11/29 06:00
CRDT- 2017/10/12 06:00
PHST- 2017/02/10 00:00 [received]
PHST- 2017/10/06 00:00 [accepted]
PHST- 2017/10/12 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2017/10/12 06:00 [entrez]
AID - S0378-1119(17)30828-4 [pii]
AID - 10.1016/j.gene.2017.10.015 [doi]
PST - ppublish
SO  - Gene. 2018 Jan 30;641:105-110. doi: 10.1016/j.gene.2017.10.015. Epub 2017 Oct 7.