PMID- 2901895
OWN - NLM
STAT- MEDLINE
DCOM- 19881123
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 457
IP  - 1
DP  - 1988 Aug 2
TI  - Enhancement of morphine-induced analgesia after repeated injections of 
      methylenedioxymethamphetamine.
PG  - 136-42
AB  - Repeated administration of methylenedioxymethamphetamine (MDMA) to rats results 
      in long-term depletion of serotonin (5-hydroxytryptamine; 5-HT) in several brain 
      regions. Because of the apparent role of 5-HT in morphine-induced 
      antinociception, the present experiment was designed to determine the effects of 
      repeated MDMA injections on morphine-induced analgesia. Rats (n = 48) received 8 
      s.c. injections (one every 12 h for 4 days) of MDMA (20 mg/kg) or saline (1.0 
      ml/kg). Two weeks after the last injection, the groups were divided into 4 
      subgroups that received either saline, or morphine 2.5, 3.55 or 5.0 mg/kg (s.c.). 
      Nociception was assayed before and after saline or morphine administration by the 
      method of tail immersion in warm water (55 degrees C). The day after analgesia 
      testing, the animals were sacrificed, brains and spinal cords removed and 5-HT, 
      norepinephrine (NE) and dopamine (DA) levels in various brain and spinal cord 
      regions were assayed. The analgesic effect of morphine was enhanced in rats that 
      had received repeated MDMA injections. MDMA selectively depleted 5-HT in the 
      cortex, hippocampus, striatum, brainstem and in the cervical portion of spinal 
      cord. However, 5-HT levels were not changed in the thoracic and lumbar segments 
      of the spinal cord. Thus, a functional consequence of repeated MDMA 
      administration in rats was to enhance morphine-induced antinociception in 
      association with reductions in brain and cervical spinal cord 5-HT.(ABSTRACT 
      TRUNCATED AT 250 WORDS)
FAU - Nencini, P
AU  - Nencini P
AD  - Department of Psychiatry, University of Chicago, IL 60637.
FAU - Woolverton, W L
AU  - Woolverton WL
FAU - Seiden, L S
AU  - Seiden LS
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Amphetamines)
RN  - 0 (Catecholamines)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 76I7G6D29C (Morphine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
MH  - Amphetamines/*pharmacology
MH  - *Analgesia
MH  - Animals
MH  - Body Weight/drug effects
MH  - Catecholamines/metabolism
MH  - Central Nervous System/drug effects/metabolism/*physiopathology
MH  - Drug Interactions
MH  - Male
MH  - Morphine/*pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Pain/*metabolism/physiopathology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/metabolism/*physiology
EDAT- 1988/08/02 00:00
MHDA- 1988/08/02 00:01
CRDT- 1988/08/02 00:00
PHST- 1988/08/02 00:00 [pubmed]
PHST- 1988/08/02 00:01 [medline]
PHST- 1988/08/02 00:00 [entrez]
AID - 0006-8993(88)90065-0 [pii]
AID - 10.1016/0006-8993(88)90065-0 [doi]
PST - ppublish
SO  - Brain Res. 1988 Aug 2;457(1):136-42. doi: 10.1016/0006-8993(88)90065-0.