PMID- 29020982
OWN - NLM
STAT- MEDLINE
DCOM- 20180713
LR  - 20181113
IS  - 1944-446X (Electronic)
IS  - 1000-467X (Print)
IS  - 1944-446X (Linking)
VI  - 36
IP  - 1
DP  - 2017 Oct 11
TI  - The prognostic value of C-X-C motif chemokine receptor 4 in patients with 
      sporadic malignant peripheral nerve sheath tumors.
PG  - 80
LID - 10.1186/s40880-017-0246-z [doi]
LID - 80
AB  - BACKGROUND: Recent studies indicate that C-X-C motif chemokine receptor 4 (CXCR4) 
      and its ligand, C-X-C motif chemokine ligand 12 (CXCL12), stimulate expression of 
      the cell cycle regulatory protein Cyclin D1 in neurofibromatosis 1-associated 
      malignant peripheral nerve sheath tumor (MPNST) cells and promote their 
      proliferation. In this study, we measured the expression of CXCR4, CXCL12, and 
      Cyclin D1 proteins in sporadic MPNST tissues from Chinese patients and 
      investigated their prognostic values. METHODS: CXCR4, CXCL12, and Cyclin D1 
      protein expression in samples from 58 Chinese patients with sporadic MPNST was 
      assessed with immunohistochemical staining. Their prognostic values were 
      evaluated with Kaplan-Meier analysis and a log-rank test. Multivariate Cox 
      regression analysis was used to identify independent prognostic factors. RESULTS: 
      High expression of CXCR4, CXCL12, and Cyclin D1 was observed in 19 (32.8%), 32 
      (55.2%), and 16 (27.6%) samples, respectively. CXCR4 expression was positively 
      correlated with CXCL12 expression (r = 0.334, P = 0.010) and Cyclin D1 expression 
      (r = 0.309, P = 0.018). Patients with high CXCR4 expression showed longer overall 
      survival than those with low CXCR4 expression (chi(2) = 4.642, P = 0.031). 
      CONCLUSION: High CXCR4 expression may define a specific subtype of sporadic MPNST 
      with favorable prognosis.
FAU - Zhang, Chao
AU  - Zhang C
AD  - Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer 
      Institute & Hospital, Tianjin, 30060, P. R. China.
AD  - National Clinical Research Center for Cancer, Tianjin Medical University Cancer 
      Institute & Hospital, Tianjin, 300060, P. R. China.
AD  - Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University 
      Cancer Institute & Hospital, Tianjin, 300060, P. R. China.
FAU - Chang, Fang-Yuan
AU  - Chang FY
AD  - Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer 
      Institute & Hospital, Tianjin, 30060, P. R. China.
AD  - National Clinical Research Center for Cancer, Tianjin Medical University Cancer 
      Institute & Hospital, Tianjin, 300060, P. R. China.
AD  - Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University 
      Cancer Institute & Hospital, Tianjin, 300060, P. R. China.
FAU - Zhou, Wen-Ya
AU  - Zhou WY
AD  - Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer 
      Institute & Hospital, Tianjin, 30060, P. R. China.
AD  - National Clinical Research Center for Cancer, Tianjin Medical University Cancer 
      Institute & Hospital, Tianjin, 300060, P. R. China.
AD  - Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University 
      Cancer Institute & Hospital, Tianjin, 300060, P. R. China.
FAU - Yang, Ji-Long
AU  - Yang JL
AD  - Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer 
      Institute & Hospital, Tianjin, 30060, P. R. China. yangjilong@tjmuch.com.
AD  - National Clinical Research Center for Cancer, Tianjin Medical University Cancer 
      Institute & Hospital, Tianjin, 300060, P. R. China. yangjilong@tjmuch.com.
AD  - Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University 
      Cancer Institute & Hospital, Tianjin, 300060, P. R. China. yangjilong@tjmuch.com.
LA  - eng
PT  - Journal Article
DEP - 20171011
PL  - England
TA  - Chin J Cancer
JT  - Chinese journal of cancer
JID - 101498232
RN  - 0 (CCND1 protein, human)
RN  - 0 (CXCL12 protein, human)
RN  - 0 (CXCR4 protein, human)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Receptors, CXCR4)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chemokine CXCL12/metabolism
MH  - Child
MH  - Cyclin D1/metabolism
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Neurilemmoma/*metabolism
MH  - Prognosis
MH  - Receptors, CXCR4/*metabolism
MH  - Young Adult
PMC - PMC5637246
OTO - NOTNLM
OT  - C-X-C motif chemokine ligand 12 (CXCL12)
OT  - C-X-C motif chemokine receptor 4 (CXCR4)
OT  - Cyclin D1
OT  - Sporadic malignant peripheral nerve sheath tumor
EDAT- 2017/10/13 06:00
MHDA- 2018/07/14 06:00
PMCR- 2017/10/11
CRDT- 2017/10/13 06:00
PHST- 2016/11/30 00:00 [received]
PHST- 2017/07/20 00:00 [accepted]
PHST- 2017/10/13 06:00 [entrez]
PHST- 2017/10/13 06:00 [pubmed]
PHST- 2018/07/14 06:00 [medline]
PHST- 2017/10/11 00:00 [pmc-release]
AID - 10.1186/s40880-017-0246-z [pii]
AID - 246 [pii]
AID - 10.1186/s40880-017-0246-z [doi]
PST - epublish
SO  - Chin J Cancer. 2017 Oct 11;36(1):80. doi: 10.1186/s40880-017-0246-z.