PMID- 29021366
OWN - NLM
STAT- MEDLINE
DCOM- 20171212
LR  - 20181007
IS  - 1938-3673 (Electronic)
IS  - 0741-5400 (Linking)
VI  - 102
IP  - 6
DP  - 2017 Dec
TI  - NO donors exhibit anti-inflammatory properties by modulating inflammatory 
      signatures and by regulating the life cycle of dendritic cells.
PG  - 1421-1430
LID - 10.1189/jlb.3A0916-379RR [doi]
AB  - NO mediates a variety of physiologic processes and is considered an important 
      intracellular messenger in different cellular systems. Because of its complex 
      regulation and multiple molecular and cellular targets, NO provides both 
      stimulatory and suppressive properties in the immune system. Dendritic cells 
      (DCs) are considered the most potent APCs, whose regulation has important 
      implications in the induction of an effective immune response. In this study, we 
      analyzed the effect of the compound NCX 2057, a new class of NO-releasing 
      derivatives of ferulic acid, on activation and functional properties of DCs. NCX 
      2057 was able to modulate the inflammatory program, the cytokines production, and 
      the cellular life cycle but not the maturation markers and the T cells 
      stimulatory capacity of DCs in the presence or absence of LPS. The results 
      indicate that NCX 2057 may modulate different aspects of the activation of DCs 
      and suggest novel applications of NO donors in the contest of inflammatory 
      response modulation through the life cycle regulation of DCs.
CI  - (c) Society for Leukocyte Biology.
FAU - Ripamonti, Chiara
AU  - Ripamonti C
AD  - School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; and.
FAU - Papagna, Angela
AU  - Papagna A
AD  - School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; and.
FAU - Storini, Claudio
AU  - Storini C
AD  - Nicox Research Institute, Bresso, Milan, Italy.
FAU - Miglietta, Daniela
AU  - Miglietta D
AD  - Nicox Research Institute, Bresso, Milan, Italy.
FAU - Foti, Maria
AU  - Foti M
AD  - School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; and 
      maria.foti@unimib.it.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171011
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (3-((4-hydroxy-3-methoxyphenyl)-2-propenoic acid 4-nitrooxy)butyl ester)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Butanes)
RN  - 0 (Cytokines)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Nitric Oxide Donors)
RN  - 0 (Nitrites)
RN  - 0 (Nitro Compounds)
RN  - 139874-52-5 (NF-KappaB Inhibitor alpha)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - IA7306519N (Isosorbide Dinitrate)
RN  - LX1OH63030 (isosorbide-5-mononitrate)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Antigen Presentation/drug effects
MH  - Apoptosis/drug effects
MH  - Bone Marrow Cells/cytology
MH  - Butanes/pharmacology
MH  - Cytokines/biosynthesis
MH  - Dendritic Cells/*cytology/drug effects/*metabolism
MH  - Inflammation/*pathology
MH  - Isosorbide Dinitrate/analogs & derivatives/pharmacology
MH  - Lipopolysaccharides/pharmacology
MH  - Mice, Inbred C57BL
MH  - NF-KappaB Inhibitor alpha/metabolism
MH  - Nitric Oxide Donors/*pharmacology
MH  - Nitric Oxide Synthase Type II/metabolism
MH  - Nitrites/metabolism
MH  - Nitro Compounds/pharmacology
MH  - Proteolysis/drug effects
OTO - NOTNLM
OT  - APC
OT  - cell survival
OT  - cytokines
OT  - ferulic acid
OT  - innate immunity
EDAT- 2017/10/13 06:00
MHDA- 2017/12/13 06:00
CRDT- 2017/10/13 06:00
PHST- 2016/09/07 00:00 [received]
PHST- 2017/09/22 00:00 [revised]
PHST- 2017/09/23 00:00 [accepted]
PHST- 2017/10/13 06:00 [pubmed]
PHST- 2017/12/13 06:00 [medline]
PHST- 2017/10/13 06:00 [entrez]
AID - jlb.3A0916-379RR [pii]
AID - 10.1189/jlb.3A0916-379RR [doi]
PST - ppublish
SO  - J Leukoc Biol. 2017 Dec;102(6):1421-1430. doi: 10.1189/jlb.3A0916-379RR. Epub 
      2017 Oct 11.