PMID- 29021484
OWN - NLM
STAT- MEDLINE
DCOM- 20180618
LR  - 20221207
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Print)
IS  - 0918-2918 (Linking)
VI  - 57
IP  - 1
DP  - 2018 Jan 1
TI  - Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis Complicated by 
      Periaortitis and Cranial Hypertrophic Pachymeningitis: A Report of an Autopsy 
      Case.
PG  - 107-113
LID - 10.2169/internalmedicine.8751-16 [doi]
AB  - Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a systemic 
      inflammatory disorder categorized as small-vessel vasculitis. We herein report an 
      elderly Japanese man with AAV (granulomatosis with polyangiitis affecting the 
      eyes, nose, lungs, and kidneys) who also showed periaortitis at the diagnosis and 
      developed cranial hypertrophic pachymeningitis (HP) during steroid maintenance 
      therapy. His consciousness disturbance caused by HP improved after steroid pulse 
      therapy, but he died of aspiration pneumonia. Autopsy findings showed giant cells 
      in the thickened pachymeninges and obsolete inflammatory lesions in the aortic 
      adventitia and renal tubulointerstitium. This is the first case of AAV 
      complicated by periaortitis and cranial HP.
FAU - Kaga, Hajime
AU  - Kaga H
AD  - Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate 
      School of Medicine, Japan.
FAU - Komatsuda, Atsushi
AU  - Komatsuda A
AD  - Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate 
      School of Medicine, Japan.
FAU - Saito, Masaya
AU  - Saito M
AD  - Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate 
      School of Medicine, Japan.
FAU - Nara, Mizuho
AU  - Nara M
AD  - Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate 
      School of Medicine, Japan.
FAU - Omokawa, Ayumi
AU  - Omokawa A
AD  - Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate 
      School of Medicine, Japan.
FAU - Togashi, Masaru
AU  - Togashi M
AD  - Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate 
      School of Medicine, Japan.
FAU - Okuyama, Shin
AU  - Okuyama S
AD  - Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate 
      School of Medicine, Japan.
FAU - Wakui, Hideki
AU  - Wakui H
AD  - Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate 
      School of Medicine, Japan.
AD  - Department of Life Science, Akita University Graduate School of Engineering 
      Science, Japan.
FAU - Takahashi, Naoto
AU  - Takahashi N
AD  - Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate 
      School of Medicine, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20171011
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adrenal Cortex Hormones/*therapeutic use
MH  - Aged
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/*complications/diagnostic imaging/*drug therapy
MH  - Antibodies, Antineutrophil Cytoplasmic/*blood
MH  - Asian People
MH  - Autopsy
MH  - Biomarkers/blood
MH  - Dura Mater/physiopathology
MH  - Fatal Outcome
MH  - Granulomatosis with Polyangiitis/complications/diagnosis/*drug therapy
MH  - Humans
MH  - Hypertrophy/complications/*drug therapy
MH  - Male
MH  - Meningitis/diagnosis/diagnostic imaging/*therapy
PMC - PMC5799067
OTO - NOTNLM
OT  - anti-neutrophil cytoplasmic antibody-associated vasculitis
OT  - cranial hypertrophic pachymeningitis
OT  - granulomatosis with polyangiitis
OT  - periaortitis
EDAT- 2017/10/13 06:00
MHDA- 2018/06/19 06:00
PMCR- 2018/01/01
CRDT- 2017/10/13 06:00
PHST- 2017/10/13 06:00 [pubmed]
PHST- 2018/06/19 06:00 [medline]
PHST- 2017/10/13 06:00 [entrez]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.2169/internalmedicine.8751-16 [doi]
PST - ppublish
SO  - Intern Med. 2018 Jan 1;57(1):107-113. doi: 10.2169/internalmedicine.8751-16. Epub 
      2017 Oct 11.