PMID- 29021851
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1880-4276 (Print)
IS  - 1883-2148 (Electronic)
IS  - 1880-4276 (Linking)
VI  - 33
IP  - 5
DP  - 2017 Oct
TI  - Cardiac troponin T as a predictor of cardiac death in patients with left 
      ventricular dysfunction.
PG  - 463-468
LID - 10.1016/j.joa.2017.07.004 [doi]
AB  - BACKGROUND: Cardiac troponin T (cTnT) has been reported to be associated with 
      cardiac mortality. In the present study, we evaluated the role of routine 
      assessment of cTnT as a predictor of future cardiac death in patients with left 
      ventricular (LV) dysfunction. METHODS: Patients who were eligible for 
      prophylactic implantable cardioverter defibrillator (ICD) were included from 
      cardiac catheterization database. Inclusion criteria were patients with LV 
      ejection fraction of </= 35% and with New York Heart Association (NYHA) >/=class II. 
      Exclusion criteria were patients with acute coronary syndrome, ICD for secondary 
      prevention, NYHA class IV, and lack of data. The final study patients were 
      divided into the following three groups in accordance with two quartile points of 
      serum cTnT levels: low cTnT, intermediate cTnT, and high cTnT groups. The primary 
      endpoint of this study was cardiac death. RESULTS: A total of 70 patients were 
      included (mean age, 62+/-13 years; male individuals, 56; ischemic, 36; and 
      non-ischemic, 34). During the observation period of 2.2 years, cardiac death was 
      observed in 17 patients (fatal arrhythmic event, 9; heart failure, 7; myocardial 
      infarction, 1). In the Kaplan-Meier analysis, the high cTnT group showed the 
      highest risk among all the groups (p<0.001). Even in sub-analyses for ischemic 
      and non-ischemic patients, the results were the same, and the high cTnT group 
      showed the highest event rate (p<0.05). In contrast, no cardiac death was 
      observed in the low cTnT group. CONCLUSION: The cTnT levels in a stable state 
      were associated with cardiac death in patients with LV dysfunction, even in those 
      with non-ischemic diseases.
FAU - Nakamura, Hironori
AU  - Nakamura H
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Niwano, Shinichi
AU  - Niwano S
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Fukaya, Hidehira
AU  - Fukaya H
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Murakami, Masami
AU  - Murakami M
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Kishihara, Jun
AU  - Kishihara J
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Satoh, Akira
AU  - Satoh A
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Yoshizawa, Tomoharu
AU  - Yoshizawa T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Oikawa, Jun
AU  - Oikawa J
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Ishizue, Naruya
AU  - Ishizue N
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Igarashi, Tazuru
AU  - Igarashi T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Fujiishi, Tamami
AU  - Fujiishi T
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
FAU - Ako, Junya
AU  - Ako J
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Sagamihara, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170831
PL  - Japan
TA  - J Arrhythm
JT  - Journal of arrhythmia
JID - 101263026
PMC - PMC5634714
OTO - NOTNLM
OT  - Cardiac death
OT  - Cardiac troponin T
OT  - Left ventricular dysfunction
OT  - Sudden death
EDAT- 2017/10/13 06:00
MHDA- 2017/10/13 06:01
PMCR- 2017/08/31
CRDT- 2017/10/13 06:00
PHST- 2017/04/18 00:00 [received]
PHST- 2017/06/15 00:00 [revised]
PHST- 2017/07/03 00:00 [accepted]
PHST- 2017/10/13 06:00 [entrez]
PHST- 2017/10/13 06:00 [pubmed]
PHST- 2017/10/13 06:01 [medline]
PHST- 2017/08/31 00:00 [pmc-release]
AID - S1880-4276(17)30129-1 [pii]
AID - 10.1016/j.joa.2017.07.004 [doi]
PST - ppublish
SO  - J Arrhythm. 2017 Oct;33(5):463-468. doi: 10.1016/j.joa.2017.07.004. Epub 2017 Aug 
      31.