PMID- 29022222
OWN - NLM
STAT- MEDLINE
DCOM- 20180126
LR  - 20240327
IS  - 1539-0829 (Electronic)
IS  - 1534-4827 (Print)
IS  - 1534-4827 (Linking)
VI  - 17
IP  - 11
DP  - 2017 Oct 11
TI  - T Cell Receptor Profiling in Type 1 Diabetes.
PG  - 118
LID - 10.1007/s11892-017-0946-4 [doi]
LID - 118
AB  - PURPOSE OF REVIEW: The genetic susceptibility and dominant protection for type 1 
      diabetes (T1D) associated with human leukocyte antigen (HLA) haplotypes, along 
      with minor risk variants, have long been thought to shape the T cell receptor 
      (TCR) repertoire and eventual phenotype of autoreactive T cells that mediate 
      beta-cell destruction. While autoantibodies provide robust markers of disease 
      progression, early studies tracking autoreactive T cells largely failed to 
      achieve clinical utility. RECENT FINDINGS: Advances in acquisition of pancreata 
      and islets from T1D organ donors have facilitated studies of T cells isolated 
      from the target tissues. Immunosequencing of TCR alpha/beta-chain complementarity 
      determining regions, along with transcriptional profiling, offers the potential 
      to transform biomarker discovery. Herein, we review recent studies characterizing 
      the autoreactive TCR signature in T1D, emerging technologies, and the challenges 
      and opportunities associated with tracking TCR molecular profiles during the 
      natural history of T1D.
FAU - Jacobsen, Laura M
AU  - Jacobsen LM
AD  - Department of Pediatrics, College of Medicine, University of Florida Diabetes 
      Institute, Gainesville, FL, USA.
FAU - Posgai, Amanda
AU  - Posgai A
AD  - Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, 
      University of Florida Diabetes Institute, Gainesville, FL, USA.
FAU - Seay, Howard R
AU  - Seay HR
AD  - Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, 
      University of Florida Diabetes Institute, Gainesville, FL, USA.
FAU - Haller, Michael J
AU  - Haller MJ
AD  - Department of Pediatrics, College of Medicine, University of Florida Diabetes 
      Institute, Gainesville, FL, USA.
FAU - Brusko, Todd M
AU  - Brusko TM
AD  - Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, 
      University of Florida Diabetes Institute, Gainesville, FL, USA. tbrusko@ufl.edu.
LA  - eng
GR  - P01 AI042288/AI/NIAID NIH HHS/United States
GR  - R01 DK106191/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20171011
PL  - United States
TA  - Curr Diab Rep
JT  - Current diabetes reports
JID - 101093791
RN  - 0 (Biomarkers)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Animals
MH  - Autoimmunity/immunology
MH  - Biomarkers/metabolism
MH  - Diabetes Mellitus, Type 1/*immunology
MH  - Humans
MH  - Immunotherapy
MH  - Receptors, Antigen, T-Cell/metabolism/therapeutic use
MH  - T-Lymphocytes/*immunology
PMC - PMC5636870
OTO - NOTNLM
OT  - Adaptive immunity
OT  - Autoimmunity
OT  - Human immune repertoire
OT  - Immunosequencing
OT  - T cell receptor
OT  - Type 1 diabetes
COIS- CONFLICT OF INTEREST: Laura M. Jacobsen, Amanda Posgai, Howard R. Seay, Michael 
      J. Haller, and Todd M. Brusko declare that no conflicts of interest exist 
      relevant to the contents of this work. HUMAN AND ANIMAL RIGHTS AND INFORMED 
      CONSENT: All reported studies/experiments with human or animal subjects performed 
      by the authors have been previously published and complied with all applicable 
      ethical standards (including the Helsinki Declaration and its amendments, 
      institutional/national research committee standards, and 
      international/national/institutional guidelines). Specifically, for nPOD samples, 
      deceased human organ donor tissue samples were obtained and coded by nPOD under 
      the University of Florida (UF) Institutional Review Board approved protocol 
      IRB201600029 and processed by the Brusko Lab under protocol IRB201602502.
EDAT- 2017/10/13 06:00
MHDA- 2018/01/27 06:00
PMCR- 2017/10/11
CRDT- 2017/10/13 06:00
PHST- 2017/10/13 06:00 [entrez]
PHST- 2017/10/13 06:00 [pubmed]
PHST- 2018/01/27 06:00 [medline]
PHST- 2017/10/11 00:00 [pmc-release]
AID - 10.1007/s11892-017-0946-4 [pii]
AID - 946 [pii]
AID - 10.1007/s11892-017-0946-4 [doi]
PST - epublish
SO  - Curr Diab Rep. 2017 Oct 11;17(11):118. doi: 10.1007/s11892-017-0946-4.