PMID- 29022387
OWN - NLM
STAT- MEDLINE
DCOM- 20180529
LR  - 20180529
IS  - 1876-2891 (Electronic)
IS  - 1876-2883 (Linking)
VI  - 8
IP  - 5
DP  - 2017 Oct 13
TI  - Lactobacillus plantarum IS-10506 supplementation reduced SCORAD in children with 
      atopic dermatitis.
PG  - 833-840
LID - 10.3920/BM2017.0011 [doi]
AB  - Lactobacillus plantarum IS-10506 is a novel probiotic isolated from dadih, an 
      Indonesian traditional fermented buffalo milk. It's in vitro and in vivo 
      probiotic properties have been assessed. Probiotic function has been shown in 
      vivo by the suppression of allergic reactions in BALB/c mice through the action 
      of T-regulatory cells cytokines by balancing Th1 and Th2 immune response. Atopic 
      dermatitis (AD) is a chronic recurrent inflammatory skin disease characterised by 
      the imbalance of Th1 and Th2. The aim of the study was to assess the probiotic 
      function of L. plantarum IS-10506 in children with mild and moderate AD. A 
      randomised double-blind placebo-controlled trial comparing microencapsulated L. 
      plantarum IS-10506 (10(10) cfu/day) and placebo (skim milk-Avicel) twice daily 
      for 12 weeks was conducted in an outpatient clinic on children with mild and 
      moderate AD. The trial included 22 AD children divided into intervention and 
      control groups of n=12 and n=10 patients, respectively. Scoring Atopic Dermatitis 
      Index (SCORAD) and serum immunoglobulin E (IgE), interleukin (IL)-4, interferon 
      gamma (IFN-gamma), forkhead box P3 (Foxp3+)/IL-10, and IL-17 levels were assessed. 
      Demographic and baseline characteristics were not significantly different between 
      the two groups. SCORAD and levels of IL-4, IFN-gamma, and IL-17 were significantly 
      lower in the probiotic group than those in the placebo group, while the IgE 
      levels were not significantly changed. The ratio of Foxp3+ to IL-10 was 
      significantly higher in the probiotic group than that in placebo group. 
      Supplementation with the probiotic L. plantarum IS-10506 offered a potential 
      treatment for children with AD. Further long-term studies with a larger sample 
      size are required to confirm the therapeutic efficacy of L. plantarum IS-10506 in 
      AD.
FAU - Prakoeswa, C R S
AU  - Prakoeswa CRS
AD  - 1 Dermatology and Venereology Department, Faculty of Medicine, Universitas 
      Airlangga, Dr Soetomo Teaching Hospital, Prof Dr. Moestopo No.47, 60131 Surabaya, 
      East Java, Indonesia.
FAU - Herwanto, N
AU  - Herwanto N
AD  - 1 Dermatology and Venereology Department, Faculty of Medicine, Universitas 
      Airlangga, Dr Soetomo Teaching Hospital, Prof Dr. Moestopo No.47, 60131 Surabaya, 
      East Java, Indonesia.
FAU - Prameswari, R
AU  - Prameswari R
AD  - 1 Dermatology and Venereology Department, Faculty of Medicine, Universitas 
      Airlangga, Dr Soetomo Teaching Hospital, Prof Dr. Moestopo No.47, 60131 Surabaya, 
      East Java, Indonesia.
FAU - Astari, L
AU  - Astari L
AD  - 1 Dermatology and Venereology Department, Faculty of Medicine, Universitas 
      Airlangga, Dr Soetomo Teaching Hospital, Prof Dr. Moestopo No.47, 60131 Surabaya, 
      East Java, Indonesia.
FAU - Sawitri, S
AU  - Sawitri S
AD  - 1 Dermatology and Venereology Department, Faculty of Medicine, Universitas 
      Airlangga, Dr Soetomo Teaching Hospital, Prof Dr. Moestopo No.47, 60131 Surabaya, 
      East Java, Indonesia.
FAU - Hidayati, A N
AU  - Hidayati AN
AD  - 1 Dermatology and Venereology Department, Faculty of Medicine, Universitas 
      Airlangga, Dr Soetomo Teaching Hospital, Prof Dr. Moestopo No.47, 60131 Surabaya, 
      East Java, Indonesia.
FAU - Indramaya, D M
AU  - Indramaya DM
AD  - 1 Dermatology and Venereology Department, Faculty of Medicine, Universitas 
      Airlangga, Dr Soetomo Teaching Hospital, Prof Dr. Moestopo No.47, 60131 Surabaya, 
      East Java, Indonesia.
FAU - Kusumowidagdo, E R
AU  - Kusumowidagdo ER
AD  - 2 Clinical Pathology Department, Faculty of Medicine, Universitas Airlangga, Dr 
      Soetomo Teaching Hospital, Surabaya, East Java, Indonesia.
FAU - Surono, I S
AU  - Surono IS
AD  - 3 Food Technology Department, Faculty of Engineering, Bina Nusantara University, 
      Alam Sutera, Serpong, Tangerang, Indonesia.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20171012
PL  - Netherlands
TA  - Benef Microbes
JT  - Beneficial microbes
JID - 101507616
RN  - 0 (Cytokines)
RN  - 0 (Immunologic Factors)
RN  - 0 (Placebos)
SB  - IM
MH  - Animals
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/blood
MH  - Dermatitis, Atopic/*pathology/*therapy
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Immunologic Factors/*administration & dosage
MH  - Indonesia
MH  - Lactobacillus plantarum/*growth & development
MH  - Male
MH  - Placebos/administration & dosage
MH  - Probiotics/*administration & dosage
MH  - *Severity of Illness Index
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Lactobacillus plantarum IS-10506
OT  - SCORAD
OT  - atopic dermatitis
OT  - children
OT  - probiotic
EDAT- 2017/10/13 06:00
MHDA- 2018/05/31 06:00
CRDT- 2017/10/13 06:00
PHST- 2017/10/13 06:00 [pubmed]
PHST- 2018/05/31 06:00 [medline]
PHST- 2017/10/13 06:00 [entrez]
AID - 10.3920/BM2017.0011 [doi]
PST - ppublish
SO  - Benef Microbes. 2017 Oct 13;8(5):833-840. doi: 10.3920/BM2017.0011. Epub 2017 Oct 
      12.