PMID- 29022646
OWN - NLM
STAT- MEDLINE
DCOM- 20180712
LR  - 20180712
IS  - 2299-8306 (Electronic)
IS  - 0423-104X (Linking)
VI  - 68
IP  - 6
DP  - 2017
TI  - Low skeletal mass is an important predictor of osteoporosis in HIV-infected men 
      in India.
PG  - 642-651
LID - 10.5603/EP.a2017.0053 [doi]
AB  - INTRODUCTION: This study evaluated prevalence and predictors of osteoporosis and 
      sarcopenia in men with HIV. MATERIAL AND METHODS: 220 men with HIV were screened, 
      of which 115 men, 30-50 years-age, having at least 1-year follow-up, underwent 
      hormonal and DEXA analysis. 40 controls were also evaluated. RESULTS: Males with 
      HIV had significantly lower BMD and Z-scores at all sites. Osteoporosis was 
      diagnosed in 64.35%; commonest site being radius total (49.56%), followed by 
      radius 33% (45.21%), radius ultra distal (36.52%), lumbar spine (19.13%), neck of 
      femur (17.39%), total femur and greater trochanter (7.82% each). HIV patients had 
      significantly lower fat mass (FM), lean mass (LM), total fat percent, bone 
      mineral content, gynoid fat, percent skeletal muscle mass (PSMM). Men with 
      osteoporosis had higher use of anti retroviral therapy (ART), immune 
      reconstitution inflammatory syndrome (IRIS), tuberculosis, lower FM, LM and PSMM. 
      Logistic regression revealed PSMM, age and delta (Delta) CD4 count (change in CD4 
      count after 6-12 months of ART, compared to pre-ART) were best predictors of 
      osteoporosis. Greater PSMM was associated with decreased osteoporosis, without 
      adjusting for any variable (Model-1), adjusting for disease duration, 
      tuberculosis and IRIS (Model-2), and model-2 plus gonadotropins and sex steroids 
      (Model-3). Greater DeltaCD4 count and age were associated with increased osteoporosis 
      after adjusting for different models. Sarcopenia was observed in 40% men and none 
      in controls. CONCLUSIONS: Men with decreased skeletal mass, age, severe immune 
      dysfunction at diagnosis, having rapid increase in CD4 count following ART and 
      IRIS have higher risk of osteoporosis in the long run.
FAU - Dutta, Deep
AU  - Dutta D
AD  - Dr Deep Dutta Consultant & Head, Department of Endocrinology Diabetology & 
      Metabolic Disorders, Venkateshwar Hospitals, New Delhi, India Assistant 
      Professor, Department of Endocrinology, Endocrine Clinic, Nursing Home Annex, 
      Post Graduate Institute of Medical Education & Research (PGIMER) and Dr. Ram 
      Manohar Lohia (RML) Hospital, Baba Kharak Singh Marg, New Delhi-110001; Phone: 
      +919911544096; e-mail: deepdutta2000@yahoo.com. deepdutta2000@yahoo.com.
FAU - Sharma, Meha
AU  - Sharma M
FAU - Bansal, Rahul
AU  - Bansal R
FAU - Sharma, Neera
AU  - Sharma N
FAU - Garga, Umesh Chandra
AU  - Garga UC
FAU - Anand, Atul
AU  - Anand A
FAU - Gaurav, Kumar
AU  - Gaurav K
LA  - eng
PT  - Journal Article
DEP - 20171012
PL  - Poland
TA  - Endokrynol Pol
JT  - Endokrynologia Polska
JID - 0370674
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - HIV Infections/*complications
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteoporosis/*epidemiology/etiology
MH  - Prevalence
MH  - Risk Factors
MH  - Sarcopenia/*etiology
OTO - NOTNLM
OT  - HIV
OT  - fat mass
OT  - lean mass
OT  - osteoporosis
OT  - skeletal mass
EDAT- 2017/10/13 06:00
MHDA- 2018/07/13 06:00
CRDT- 2017/10/13 06:00
PHST- 2017/02/04 00:00 [received]
PHST- 2017/03/09 00:00 [accepted]
PHST- 2017/10/13 06:00 [pubmed]
PHST- 2018/07/13 06:00 [medline]
PHST- 2017/10/13 06:00 [entrez]
AID - VM/OJS/J/50548 [pii]
AID - 10.5603/EP.a2017.0053 [doi]
PST - ppublish
SO  - Endokrynol Pol. 2017;68(6):642-651. doi: 10.5603/EP.a2017.0053. Epub 2017 Oct 12.