PMID- 29023633 OWN - NLM STAT- MEDLINE DCOM- 20180209 LR - 20220330 IS - 1600-0447 (Electronic) IS - 0001-690X (Linking) VI - 136 IP - 6 DP - 2017 Dec TI - BDNF and BMI effects on brain structures of bipolar offspring: results from the global mood and brain science initiative. PG - 607-614 LID - 10.1111/acps.12822 [doi] AB - OBJECTIVE: To compare brain-derived neurotrophic factor (BDNF) levels between offspring of individuals with bipolar disorders (BD) and healthy controls (HCs) and investigate the effects of BDNF levels and body mass index (BMI) on brain structures. METHOD: Sixty-seven bipolar offspring and 45 HCs were included (ages 8-28). Structural images were acquired using 3.0 Tesla magnetic resonance imaging. Serum BDNF levels were measured using enzyme-linked immunosorbent assay. Multivariate and univariate analyses of covariance were conducted. RESULTS: Significantly higher BDNF levels were observed among bipolar offspring, relative to HCs (P > 0.025). Offspring status moderated the association between BDNF and BMI (F(1) =4.636, P = 0.034). After adjustment for relevant covariates, there was a trend for a significant interaction of group and BDNF on neuroimaging parameters (Wilks'lambda F(56,94) =1.463, P = 0.052), with significant effects on cerebellar white matter and superior and middle frontal regions. Brain volume and BDNF were positively correlated among HCs and negatively correlated among bipolar offspring. Interactions between BDNF and BMI on brain volumes were non-significant among HCs (Wilks'lambda F(28,2) =2.229, P = 0.357), but significant among bipolar offspring (Wilks'lambda F(28,12) =2.899, P = 0.028). CONCLUSION: Offspring status and BMI moderate the association between BDNF levels and brain structures among bipolar offspring, underscoring BDNF regulation and overweight/obesity as key moderators of BD pathogenesis. CI - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. FAU - Mansur, R B AU - Mansur RB AD - Department of Affective Disorders, the Affiliated Hospital of Guangzhou Medical University, (Guangzhou Huiai Hospital), Guangzhou Medical University, Guangzhou, China. AD - Department of Psychiatry, University of Toronto, Toronto, ON, Canada. AD - Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada. FAU - Brietzke, E AU - Brietzke E AUID- ORCID: 0000-0003-2697-1342 AD - Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada. AD - Department of Psychiatry, Universidade Federal de Sao Paulo, Sao Paulo, Brazil. FAU - McIntyre, R S AU - McIntyre RS AUID- ORCID: 0000-0003-4733-2523 AD - Department of Affective Disorders, the Affiliated Hospital of Guangzhou Medical University, (Guangzhou Huiai Hospital), Guangzhou Medical University, Guangzhou, China. AD - Department of Psychiatry, University of Toronto, Toronto, ON, Canada. AD - Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada. AD - Institute of Medical Science, University of Toronto, Toronto, ON, Canada. FAU - Cao, B AU - Cao B AUID- ORCID: 0000-0003-3401-6900 AD - Department of Affective Disorders, the Affiliated Hospital of Guangzhou Medical University, (Guangzhou Huiai Hospital), Guangzhou Medical University, Guangzhou, China. AD - Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA. FAU - Lee, Y AU - Lee Y AD - Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada. AD - Institute of Medical Science, University of Toronto, Toronto, ON, Canada. FAU - Japiassu, L AU - Japiassu L AD - Department of Psychiatry, University of Toronto, Toronto, ON, Canada. FAU - Chen, K AU - Chen K AD - Department of Affective Disorders, the Affiliated Hospital of Guangzhou Medical University, (Guangzhou Huiai Hospital), Guangzhou Medical University, Guangzhou, China. AD - Laboratory of Emotion and Cognition, the Affiliated Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou Medical University, Guangzhou, China. FAU - Lu, R AU - Lu R AD - Department of Affective Disorders, the Affiliated Hospital of Guangzhou Medical University, (Guangzhou Huiai Hospital), Guangzhou Medical University, Guangzhou, China. FAU - Lu, W AU - Lu W AD - Department of Affective Disorders, the Affiliated Hospital of Guangzhou Medical University, (Guangzhou Huiai Hospital), Guangzhou Medical University, Guangzhou, China. FAU - Li, T AU - Li T AD - Department of Affective Disorders, the Affiliated Hospital of Guangzhou Medical University, (Guangzhou Huiai Hospital), Guangzhou Medical University, Guangzhou, China. FAU - Xu, G AU - Xu G AD - Department of Affective Disorders, the Affiliated Hospital of Guangzhou Medical University, (Guangzhou Huiai Hospital), Guangzhou Medical University, Guangzhou, China. AD - Laboratory of Emotion and Cognition, the Affiliated Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou Medical University, Guangzhou, China. FAU - Lin, K AU - Lin K AD - Department of Affective Disorders, the Affiliated Hospital of Guangzhou Medical University, (Guangzhou Huiai Hospital), Guangzhou Medical University, Guangzhou, China. AD - Laboratory of Emotion and Cognition, the Affiliated Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou Medical University, Guangzhou, China. AD - Laboratory of Neuropsychology, University of Hong Kong, Hong Kong, Hong Kong. LA - eng PT - Journal Article DEP - 20171011 PL - United States TA - Acta Psychiatr Scand JT - Acta psychiatrica Scandinavica JID - 0370364 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adolescent MH - Adult MH - Affect MH - Bipolar Disorder/*blood/pathology MH - *Body Mass Index MH - Brain/*diagnostic imaging/*pathology MH - Brain-Derived Neurotrophic Factor/*blood MH - Child MH - Enzyme-Linked Immunosorbent Assay MH - Female MH - Humans MH - *Magnetic Resonance Imaging MH - Male MH - Neuroimaging MH - Organ Size MH - Young Adult OTO - NOTNLM OT - bipolar disorder OT - mood disorders OT - obesity OT - risk factors EDAT- 2017/10/13 06:00 MHDA- 2018/02/10 06:00 CRDT- 2017/10/13 06:00 PHST- 2017/09/19 00:00 [accepted] PHST- 2017/10/13 06:00 [pubmed] PHST- 2018/02/10 06:00 [medline] PHST- 2017/10/13 06:00 [entrez] AID - 10.1111/acps.12822 [doi] PST - ppublish SO - Acta Psychiatr Scand. 2017 Dec;136(6):607-614. doi: 10.1111/acps.12822. Epub 2017 Oct 11.