PMID- 29023924
OWN - NLM
STAT- MEDLINE
DCOM- 20180906
LR  - 20190221
IS  - 1365-2559 (Electronic)
IS  - 0309-0167 (Linking)
VI  - 72
IP  - 6
DP  - 2018 May
TI  - A decreased peritumoral CD1a+ cell number predicts a worse prognosis in oral 
      squamous cell carcinoma.
PG  - 905-913
LID - 10.1111/his.13415 [doi]
AB  - AIMS: Dendritic cells (DCs) are known to play a central role in the regulation of 
      both innate and adaptive immunological responses, including antitumour immunity. 
      The aim of this study was to evaluate the prognostic impact of intratumoral and 
      peritumoral DCs in oral squamous cell carcinoma (OSCC) affecting the tongue and 
      floor of the mouth. METHODS AND RESULTS: Immunohistochemistry for CD1a and CD83 
      was performed in 53 patients with OSCC in the tongue and floor of the mouth. The 
      markers were evaluated by automated examination in intratumoral and peritumoral 
      compartments, and the results were expressed as density of cells/mm(2) . 
      Correlations between these data and clinicopathological and survival outcomes 
      were investigated. Depletion of peritumoral CD1a+ cells was associated with lymph 
      node metastasis (P = 0.05), whereas depletion of peritumoral CD83+ cells was 
      correlated with smoking history (P = 0.04), lymph node metastasis (P = 0.015), 
      and extracapsular spread of lymph nodes (P = 0.018). Peritumoral CD1a+ was 
      correlated with recurrence (P = 0.007) and overall survival (P = 0.03). The 
      results of the survival analysis with the Cox proportional hazard model showed 
      that depletion of peritumoral CD1a+ cells is an independent factor associated 
      with overall survival and disease-free survival. CONCLUSION: Our results suggest 
      that depletion of peritumoral CD1a+ cells is a strong independent prognostic 
      factor, predicting a higher recurrence rates and worse survival outcomes.
CI  - (c) 2017 John Wiley & Sons Ltd.
FAU - Jardim, Juscelino F
AU  - Jardim JF
AUID- ORCID: 0000-0002-8964-996X
AD  - Department of Oral Diagnosis, Piracicaba Dental School, State University of 
      Campinas, Piracicaba, Sao Paulo, Brazil.
FAU - Gondak, Rogerio
AU  - Gondak R
AD  - Department of Pathology, Federal University of Santa Catarina, Florianopolis, 
      Santa Catarina, Brazil.
FAU - Galvis, Marisol M
AU  - Galvis MM
AUID- ORCID: 0000-0003-4798-584X
AD  - Department of Oral Diagnosis, Piracicaba Dental School, State University of 
      Campinas, Piracicaba, Sao Paulo, Brazil.
FAU - Pinto, Clovis A L
AU  - Pinto CAL
AD  - Department of Pathology, AC Camargo Cancer Centre, Sao Paulo, Sao Paulo, Brazil.
FAU - Kowalski, Luiz P
AU  - Kowalski LP
AD  - Department of Head and Neck Surgery and Otorhinolaryngology, AC Camargo Cancer 
      Centre, Sao Paulo, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20180206
PL  - England
TA  - Histopathology
JT  - Histopathology
JID - 7704136
RN  - 0 (Antigens, CD1)
RN  - 0 (CD1a antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, CD1/analysis
MH  - Carcinoma, Squamous Cell/*immunology/mortality/pathology
MH  - Dendritic Cells/*pathology
MH  - Disease-Free Survival
MH  - Female
MH  - Head and Neck Neoplasms/*immunology/mortality/pathology
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/*immunology/mortality/pathology
MH  - Neoplasm Recurrence, Local/immunology/pathology
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Squamous Cell Carcinoma of Head and Neck
OTO - NOTNLM
OT  - dendritic cells
OT  - oral cancer
OT  - oral squamous cell carcinoma
OT  - prognosis
EDAT- 2017/10/13 06:00
MHDA- 2018/09/07 06:00
CRDT- 2017/10/13 06:00
PHST- 2017/03/14 00:00 [received]
PHST- 2017/10/08 00:00 [accepted]
PHST- 2017/10/13 06:00 [pubmed]
PHST- 2018/09/07 06:00 [medline]
PHST- 2017/10/13 06:00 [entrez]
AID - 10.1111/his.13415 [doi]
PST - ppublish
SO  - Histopathology. 2018 May;72(6):905-913. doi: 10.1111/his.13415. Epub 2018 Feb 6.