PMID- 29024578
OWN - NLM
STAT- MEDLINE
DCOM- 20180727
LR  - 20180727
IS  - 1932-8494 (Electronic)
IS  - 1932-8486 (Linking)
VI  - 301
IP  - 1
DP  - 2018 Jan
TI  - Morpho-Functional Features of the Gonads of Danio rerio: the Role of 
      Brain-Derived Neurotrophic Factor.
PG  - 140-147
LID - 10.1002/ar.23702 [doi]
AB  - Zebrafish, a suitable and widely used teleost fish model in basic biomedical 
      research, displays morphophysiological features of adult gonads that share some 
      commonalities with those of mammalian species. In mammals, gametogenesis is 
      regulated, among several factors, by brain-derived neurotrophic factor (BDNF). 
      This neurotrophin has a well-established role in the developing and adult nervous 
      system, as well as gonads development and functions in vertebrate species. We 
      hypothesize that BDNF has a role also in the gonadal functions of zebrafish. At 
      this purpose, we investigated BDNF and its receptors p75 and TrkB in the ovary 
      and testis of adult zebrafish, kept under laboratory conditions. Our results 
      display (1) the expression of BDNF mRNA and pro-BDNF protein outside of the 
      nervous system, specifically in the ovary and testis; (2) the presence of 
      pro-BDNF in primary oocytes and follicular layer, and p75 in follicular cells; 
      (3) the localization of pro-BDNF in type B spermatogonia, and Sertoli cells in 
      testis. Altogether, these data lead us to consider that BDNF is involved in the 
      gonadal function of adult zebrafish, and mainly in the adult ovary. Anat Rec, 
      2017. (c) 2017 Wiley Periodicals, Inc. Anat Rec, 301:140-147, 2018. (c) 2017 Wiley 
      Periodicals, Inc.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Cacialli, Pietro
AU  - Cacialli P
AD  - Department of Veterinary Medicine and Animal Productions, University of Naples 
      Federico II, via F. Delpino, 1 Napoli, Italy.
AD  - UFR Sciences de la vie et de l'environnement, Universite de Rennes 1, Campus de 
      Beaulieu - Batiment 13 263 Avenue General Leclerc - CS 74205, Rennes Cedex 35042, 
      France.
FAU - D'Angelo, Livia
AU  - D'Angelo L
AUID- ORCID: 0000-0001-5050-642X
AD  - Department of Veterinary Medicine and Animal Productions, University of Naples 
      Federico II, via F. Delpino, 1 Napoli, Italy.
FAU - de Girolamo, Paolo
AU  - de Girolamo P
AD  - Department of Veterinary Medicine and Animal Productions, University of Naples 
      Federico II, via F. Delpino, 1 Napoli, Italy.
FAU - Avallone, Luigi
AU  - Avallone L
AD  - Department of Veterinary Medicine and Animal Productions, University of Naples 
      Federico II, via F. Delpino, 1 Napoli, Italy.
FAU - Lucini, Carla
AU  - Lucini C
AD  - Department of Veterinary Medicine and Animal Productions, University of Naples 
      Federico II, via F. Delpino, 1 Napoli, Italy.
FAU - Pellegrini, Elisabeth
AU  - Pellegrini E
AD  - UFR Sciences de la vie et de l'environnement, Universite de Rennes 1, Campus de 
      Beaulieu - Batiment 13 263 Avenue General Leclerc - CS 74205, Rennes Cedex 35042, 
      France.
FAU - Castaldo, Luciana
AU  - Castaldo L
AD  - Department of Veterinary Medicine and Animal Productions, University of Naples 
      Federico II, via F. Delpino, 1 Napoli, Italy.
LA  - eng
PT  - Journal Article
DEP - 20171027
PL  - United States
TA  - Anat Rec (Hoboken)
JT  - Anatomical record (Hoboken, N.J. : 2007)
JID - 101292775
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptor, Nerve Growth Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Female
MH  - Male
MH  - Oocytes/metabolism
MH  - Ovary/anatomy & histology/*physiology
MH  - RNA, Messenger/metabolism
MH  - Receptor, Nerve Growth Factor/physiology
MH  - Receptor, trkB/physiology
MH  - Sertoli Cells/metabolism
MH  - Spermatogonia/metabolism
MH  - Testis/anatomy & histology/*physiology
MH  - Zebrafish/anatomy & histology/*physiology
OTO - NOTNLM
OT  - BDNF
OT  - TrkB
OT  - gonads
OT  - p75
OT  - zebrafish
EDAT- 2017/10/13 06:00
MHDA- 2018/07/28 06:00
CRDT- 2017/10/13 06:00
PHST- 2017/03/02 00:00 [received]
PHST- 2017/08/16 00:00 [revised]
PHST- 2017/08/23 00:00 [accepted]
PHST- 2017/10/13 06:00 [pubmed]
PHST- 2018/07/28 06:00 [medline]
PHST- 2017/10/13 06:00 [entrez]
AID - 10.1002/ar.23702 [doi]
PST - ppublish
SO  - Anat Rec (Hoboken). 2018 Jan;301(1):140-147. doi: 10.1002/ar.23702. Epub 2017 Oct 
      27.