PMID- 29026333
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1178-7090 (Print)
IS  - 1178-7090 (Electronic)
IS  - 1178-7090 (Linking)
VI  - 10
DP  - 2017
TI  - Analgesic efficacy and safety of epidural oxycodone in patients undergoing total 
      hip arthroplasty: a pilot study.
PG  - 2303-2309
LID - 10.2147/JPR.S144799 [doi]
AB  - BACKGROUND AND OBJECTIVES: Oxycodone is poorly studied as an adjuvant to central 
      blockades. The aim of this pilot study was to assess the efficacy and safety of 
      oxycodone hydrochloride in epidural blockade among patients undergoing total hip 
      arthroplasty (THA). PATIENTS AND METHODS: In 11 patients (American Society of 
      Anesthesiologists physical status classification system II/III, age range: 59-82 
      years), THA was conducted with an epidural blockade using 15 mL 0.25% bupivacaine 
      (37.5 mg) with 5 mg oxycodone hydrochloride and sedation with propofol infusion 
      at a dose of 3-5 mg/kg/h. After the surgery, patients received ketoprofen at a 
      dose of 100 mg twice daily. In the first 24 hours postoperative period, pain was 
      assessed by numerical rating scale at rest and on movement; adverse effects (AEs) 
      were recorded; and plasma concentrations of oxycodone, noroxycodone, and 
      bupivacaine were measured. RESULTS: The administration of epidural oxycodone at a 
      dose of 5 mg in patients undergoing THA provided analgesia for a mean time of 
      10.3+/-4.89 h. In one patient, mild pruritus was observed. Oxycodone did not evoke 
      other AEs. Plasma concentrations of oxycodone while preserving analgesia were 
      >2.9 ng/mL. Noroxycodone concentrations in plasma did not guarantee analgesic 
      effect. CONCLUSION: The administration of epidural oxycodone at a dose of 5 mg 
      prolongs the analgesia period to ~10 hours in patients after THA. Oxycodone may 
      evoke pruritus. A 5 mg dose of oxycodone hydrochloride used in an epidural 
      blockade seems to be a safe drug in patients after THA.
FAU - Olczak, Bogumil
AU  - Olczak B
AD  - Department of Anaesthesiology, Jozef Strus Multiprofile Municipal Hospital, 
      Poznan.
FAU - Kowalski, Grzegorz
AU  - Kowalski G
AD  - Department of Anaesthesiology, Jozef Strus Multiprofile Municipal Hospital, 
      Poznan.
AD  - Department of Palliative Medicine.
FAU - Leppert, Wojciech
AU  - Leppert W
AD  - Department of Palliative Medicine.
FAU - Bienert, Agnieszka
AU  - Bienert A
AD  - Department of Clinical Pharmacy and Biopharmacy.
FAU - Tezyk, Artur
AU  - Tezyk A
AD  - Department of Forensic Medicine, Poznan University of Medical Sciences, Poznan, 
      Poland.
FAU - Adamski, Michal
AU  - Adamski M
AD  - Department of Anaesthesiology, Jozef Strus Multiprofile Municipal Hospital, 
      Poznan.
FAU - Rzymski, Stanislaw
AU  - Rzymski S
AD  - Department of Anaesthesiology, Jozef Strus Multiprofile Municipal Hospital, 
      Poznan.
FAU - Wieczorowska-Tobis, Katarzyna
AU  - Wieczorowska-Tobis K
AD  - Department of Palliative Medicine.
LA  - eng
PT  - Journal Article
DEP - 20170927
PL  - New Zealand
TA  - J Pain Res
JT  - Journal of pain research
JID - 101540514
PMC - PMC5627752
OTO - NOTNLM
OT  - analgesia
OT  - oxycodone
OT  - pain
OT  - total hip arthroplasty
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2017/10/14 06:00
MHDA- 2017/10/14 06:01
PMCR- 2017/09/27
CRDT- 2017/10/14 06:00
PHST- 2017/10/14 06:00 [entrez]
PHST- 2017/10/14 06:00 [pubmed]
PHST- 2017/10/14 06:01 [medline]
PHST- 2017/09/27 00:00 [pmc-release]
AID - jpr-10-2303 [pii]
AID - 10.2147/JPR.S144799 [doi]
PST - epublish
SO  - J Pain Res. 2017 Sep 27;10:2303-2309. doi: 10.2147/JPR.S144799. eCollection 2017.