PMID- 29026589
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231112
IS  - 2050-2974 (Print)
IS  - 2050-2974 (Electronic)
IS  - 2050-2974 (Linking)
VI  - 5
DP  - 2017
TI  - A retrospective analysis of biochemical and haematological parameters in patients 
      with eating disorders.
PG  - 32
LID - 10.1186/s40337-017-0158-y [doi]
LID - 32
AB  - BACKGROUND: The objective of the study was to determine whether levels of 
      biochemical and haematological parameters in patients with eating disorders (EDs) 
      varied from the general population. Whilst dietary restrictions can lead to 
      nutritional deficiencies, specific abnormalities may be relevant to the 
      diagnosis, pathogenesis and treatment of EDs. METHODS: With ethics approval and 
      informed consent, a retrospective chart audit was conducted of 113 patients with 
      EDs at a general practice in Brisbane, Australia. This was analysed first as a 
      total group (TG) and then in 4 ED subgroups: Anorexia nervosa (AN), Bulimia 
      nervosa (BN), ED Not Otherwise Specified (EDNOS), and AN/BN. Eighteen parameters 
      were assessed at or near first presentation: cholesterol, folate, vitamin B12, 
      magnesium, manganese, zinc, calcium, potassium, urate, sodium, albumin, 
      phosphate, ferritin, vitamin D, white cell count, neutrophils, red cell count and 
      platelets. Results were analysed using IBM SPSS 21 and Microsoft Excel 2013 by 
      two-tailed, one-sample t-tests (TG and 4 subgroups) and chi-square tests (TG 
      only) and compared to the population mean standards. Results for the TG and each 
      subgroup individually were then compared with the known reference interval (RI). 
      RESULTS: For the total sample, t-tests showed significant differences for all 
      parameters (p < 0.05) except cholesterol. Most parameters gave results below 
      population levels, but folate, phosphate, albumin, calcium and vitamin B12 were 
      above. More patients than expected were below the RI for most parameters in the 
      TG and subgroups. CONCLUSIONS: At diagnosis, in patients with EDs, there are 
      often significant differences in multiple haematological and biochemical 
      parameters. Early identification of these abnormalities may provide additional 
      avenues of ED treatment through supplementation and dietary guidance, and may be 
      used to reinforce negative impacts on health caused by the ED to the patient, 
      their family and their treatment team (general practitioner, dietitian and mental 
      health professionals). Study data would support routine measurement of a full 
      blood count and electrolytes, phosphate, magnesium, liver function tests, 
      ferritin, vitamin B12, red cell folate, vitamin D, manganese and zinc for all 
      patients at first presentation with an ED.
FAU - Barron, Leanne J
AU  - Barron LJ
AD  - Brisbane City Doctors Medical Practice, Brisbane, QLD Australia.
AD  - Eating Disorders Multidisciplinary Clinic, Queensland University of Technology, 
      Brisbane, QLD Australia. ISNI: 0000000089150953. GRID: grid.1024.7
FAU - Barron, Robert F
AU  - Barron RF
AD  - Riverina-Murray Institute of Higher Education, Wagga Wagga, NSW Australia.
FAU - Johnson, Jeremy C S
AU  - Johnson JCS
AD  - Royal Brisbane and Women's Hospital, Brisbane, QLD Australia. ISNI: 0000 0001 
      0688 4634. GRID: grid.416100.2
FAU - Wagner, Ingrid
AU  - Wagner I
AD  - School of Public Health and Social Work, Queensland University of Technology, 
      Brisbane, QLD Australia. ISNI: 0000000089150953. GRID: grid.1024.7
AD  - Lady Cilento Children's Hospital, Brisbane, QLD Australia. GRID: grid.240562.7
FAU - Ward, Cameron J B
AU  - Ward CJB
AD  - Lady Cilento Children's Hospital, Brisbane, QLD Australia. GRID: grid.240562.7
AD  - University of Queensland, Brisbane, QLD Australia. ISNI: 0000 0000 9320 7537. 
      GRID: grid.1003.2
AD  - Mater Medical Research Institute, Brisbane, Australia. GRID: grid.1064.3
AD  - Queensland Paediatric Cardiac Research Group, Queensland, Australia.
FAU - Ward, Shannon R B
AU  - Ward SRB
AD  - University of Queensland, Brisbane, QLD Australia. ISNI: 0000 0000 9320 7537. 
      GRID: grid.1003.2
FAU - Barron, Faye M
AU  - Barron FM
AD  - Mount Erin College, Wagga Wagga, NSW Australia.
FAU - Ward, Warren K
AU  - Ward WK
AD  - Eating Disorders Service, Royal Brisbane and Women's Hospital, Brisbane, QLD 
      Australia. ISNI: 0000 0001 0688 4634. GRID: grid.416100.2
AD  - School of Medicine, University of Queensland, Brisbane, QLD Australia. ISNI: 0000 
      0000 9320 7537. GRID: grid.1003.2
LA  - eng
PT  - Journal Article
DEP - 20171002
PL  - England
TA  - J Eat Disord
JT  - Journal of eating disorders
JID - 101610672
PMC - PMC5623971
OTO - NOTNLM
OT  - Biochemical
OT  - Eating disorders
OT  - General practice
OT  - Haematological
OT  - Parameter
OT  - Primary care
OT  - Reference interval
OT  - Retrospective
EDAT- 2017/10/14 06:00
MHDA- 2017/10/14 06:01
PMCR- 2017/10/02
CRDT- 2017/10/14 06:00
PHST- 2016/12/15 00:00 [received]
PHST- 2017/06/08 00:00 [accepted]
PHST- 2017/10/14 06:00 [entrez]
PHST- 2017/10/14 06:00 [pubmed]
PHST- 2017/10/14 06:01 [medline]
PHST- 2017/10/02 00:00 [pmc-release]
AID - 158 [pii]
AID - 10.1186/s40337-017-0158-y [doi]
PST - epublish
SO  - J Eat Disord. 2017 Oct 2;5:32. doi: 10.1186/s40337-017-0158-y. eCollection 2017.