PMID- 29027627
OWN - NLM
STAT- MEDLINE
DCOM- 20180720
LR  - 20181113
IS  - 1559-1166 (Electronic)
IS  - 0895-8696 (Linking)
VI  - 63
IP  - 3-4
DP  - 2017 Dec
TI  - Association of TNF-alpha-3959T/C Gene Polymorphisms in the Chinese Population with 
      Intracranial Aneurysms.
PG  - 349-354
LID - 10.1007/s12031-017-0985-y [doi]
AB  - Recent studies have demonstrated that cytokines play an important role in the 
      pathogenesis of intracranial aneurysm (IA). Tumor necrosis factor-alpha (TNF-alpha) is an 
      important proinflammatory cytokine, which was shown to influence the development 
      of IA, but there is no research data from China. Hence, the purpose of this study 
      was to explore the relationship between TNF-alpha polymorphisms and IA in China. The 
      association of genetic variants of TNF-alpha gene expression was investigated in a 
      Chinese population with IA. The TNF-alpha-3959T>C(rs1799964), 4127C>A(rs1800630), 
      4133C>T(rs1799724), 4184C>T(rs4248158), and 4752G>A(rs361525) gene polymorphisms 
      in 192 IA cases and 112 controls were analyzed using polymerase chain reaction 
      (PCR). Differences in genotype and allele frequencies between patients and 
      controls were tested. There were no significant differences in 4127C>A 
      (p = 0.072), 4133C>T (p = 0.373), 4184C>T (p = 0.749), and 4752G>A (p = 0.184) 
      genotype frequencies between the IA group and the control group. But this 
      case-control association study revealed that TNF-alpha-3959T>C (p < 0.001) was 
      significantly associated with increased risk of IA. These results suggested that 
      a novel TNF-alpha locus was found to be closely correlated with the occurrence of IA 
      in Chinese.
FAU - Hu, Juntao
AU  - Hu J
AD  - Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, 430060, 
      Hubei Province, People's Republic of China.
AD  - Department of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, 
      442000, Hubei Province, People's Republic of China.
FAU - Luo, Jie
AU  - Luo J
AD  - Department of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, 
      442000, Hubei Province, People's Republic of China.
FAU - Wang, Hui
AU  - Wang H
AD  - Department of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, 
      442000, Hubei Province, People's Republic of China.
FAU - Wang, Chaojia
AU  - Wang C
AD  - Department of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, 
      442000, Hubei Province, People's Republic of China.
FAU - Sun, Xiaodong
AU  - Sun X
AD  - Department of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, 
      442000, Hubei Province, People's Republic of China.
FAU - Li, Anrong
AU  - Li A
AD  - Department of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, 
      442000, Hubei Province, People's Republic of China.
FAU - Zhou, Yi
AU  - Zhou Y
AD  - Department of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, 
      442000, Hubei Province, People's Republic of China.
FAU - Liu, Yuhang
AU  - Liu Y
AD  - Department of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, 
      442000, Hubei Province, People's Republic of China.
FAU - Chen, Qianxue
AU  - Chen Q
AUID- ORCID: 0000-0002-6067-4352
AD  - Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, 430060, 
      Hubei Province, People's Republic of China. zhuxi013@126.com.
LA  - eng
GR  - B2015492/Research Project of Hubei Provincial Department of Education/
GR  - 201410929001/Student's Platform for Innovation and Entrepreneurship Training 
      Program of Hubei Province/
PT  - Journal Article
DEP - 20171013
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - China
MH  - Female
MH  - Humans
MH  - Intracranial Aneurysm/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Tumor Necrosis Factor-alpha/*genetics
OTO - NOTNLM
OT  - Cytokine
OT  - Gene polymorphism
OT  - Intracranial aneurysm
OT  - SNP
OT  - TNF-alpha
EDAT- 2017/10/14 06:00
MHDA- 2018/07/22 06:00
CRDT- 2017/10/14 06:00
PHST- 2017/08/31 00:00 [received]
PHST- 2017/10/04 00:00 [accepted]
PHST- 2017/10/14 06:00 [pubmed]
PHST- 2018/07/22 06:00 [medline]
PHST- 2017/10/14 06:00 [entrez]
AID - 10.1007/s12031-017-0985-y [pii]
AID - 10.1007/s12031-017-0985-y [doi]
PST - ppublish
SO  - J Mol Neurosci. 2017 Dec;63(3-4):349-354. doi: 10.1007/s12031-017-0985-y. Epub 
      2017 Oct 13.