PMID- 29028482
OWN - NLM
STAT- MEDLINE
DCOM- 20180626
LR  - 20180626
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 266
DP  - 2017 Nov
TI  - Adiposity phenotypes are associated with type-2 diabetes: LAP index, body 
      adiposity index, and neck circumference.
PG  - 145-150
LID - S0021-9150(17)31293-5 [pii]
LID - 10.1016/j.atherosclerosis.2017.09.022 [doi]
AB  - BACKGROUND AND AIMS: Adiposity phenotypes can be detected by anthropometric 
      indexes associated with type-2 diabetes mellitus (T2DM). Besides body mass index 
      (BMI) and waist circumference (WC), new indices seem to be able to identify T2DM. 
      This study aimed to evaluate independent associations of T2DM with lipid 
      accumulation product (LAP index), neck circumference (NC) and body adiposity 
      index (BAI) in patients with hypertension. METHODS: A cross-sectional study was 
      carried out among 430 patients with hypertension. The T2DM diagnosed was 
      standardized. WC and NC (cm) were measured and BMI was calculated. LAP index was 
      calculated separately for men [(WC-65) x TG] and women [(WC-58) x TG]; BAI was 
      evaluated in percentiles according to hip (cm)/[height (m)(1.5)]-18. RESULTS: 
      Participants were aged 58.3 +/- 11.7 years, had systolic blood pressure (SBP) 
      154.2 +/- 24.9 mmHg, diastolic blood pressure (DBP) 89.0 +/- 14.7 mmHg, and BMI 
      30.1 +/- 6.0 kg/m(2). There was 145 men and 285 women, and 142 participants had 
      T2DM. Analyses carried out separately by gender showed that among men, BAI at the 
      75th percentile increased about 60% the risk of T2DM, while among women, those in 
      the upper quartile of LAP and NC had increased risk of T2DM (prevalence ratio 
      (PR): 2.93; 95%CI: 1.62-5.28 and 3.30; 95%IC: 1.78-6.14, respectively), after 
      adjustment for potential confounders. CONCLUSIONS: Adiposity phenotypes such as 
      LAP index and neck circumference were independently associated with T2DM in 
      hypertensive women, and BAI was associated with T2DM in men.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Marcadenti, Aline
AU  - Marcadenti A
AD  - Postgraduate Studies Program in Cardiology, School of Medicine, Universidade 
      Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Department of 
      Nutrition, Universidade Federal de Ciencias da Saude de Porto Alegre (UFCSPA), 
      Porto Alegre, RS, Brazil.
FAU - Fuchs, Flavio D
AU  - Fuchs FD
AD  - Postgraduate Studies Program in Cardiology, School of Medicine, Universidade 
      Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Division of 
      Cardiology, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil.
FAU - Moreira, Leila B
AU  - Moreira LB
AD  - Postgraduate Studies Program in Cardiology, School of Medicine, Universidade 
      Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
FAU - Gus, Miguel
AU  - Gus M
AD  - Postgraduate Studies Program in Cardiology, School of Medicine, Universidade 
      Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Division of 
      Cardiology, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil.
FAU - Fuchs, Sandra C
AU  - Fuchs SC
AD  - Postgraduate Studies Program in Cardiology, School of Medicine, Universidade 
      Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Postgraduate 
      Studies Program in Epidemiology, School of Medicine, Universidade Federal do Rio 
      Grande do Sul, R. Ramiro Barcelos 2600, CEP 90035-003, Porto Alegre, RS, Brazil. 
      Electronic address: scfuchs@terra.com.br.
LA  - eng
PT  - Journal Article
DEP - 20170922
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
SB  - IM
MH  - *Adiposity
MH  - Adult
MH  - Aged
MH  - Area Under Curve
MH  - Body Mass Index
MH  - Brazil/epidemiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*diagnosis/epidemiology/pathology/physiopathology
MH  - Female
MH  - Humans
MH  - Hypertension/*diagnosis/epidemiology/pathology/physiopathology
MH  - *Lipid Accumulation Product
MH  - Male
MH  - Middle Aged
MH  - Neck/*pathology
MH  - Obesity/*diagnosis/epidemiology/pathology/physiopathology
MH  - Phenotype
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - ROC Curve
MH  - Risk Factors
MH  - Waist Circumference
OTO - NOTNLM
OT  - Abdominal obesity
OT  - Body adiposity index
OT  - Diabetes mellitus
OT  - Hypertension
OT  - Lipid accumulation product
OT  - Neck circumference
OT  - Waist circumference
EDAT- 2017/10/14 06:00
MHDA- 2018/06/27 06:00
CRDT- 2017/10/14 06:00
PHST- 2017/06/10 00:00 [received]
PHST- 2017/08/25 00:00 [revised]
PHST- 2017/09/19 00:00 [accepted]
PHST- 2017/10/14 06:00 [pubmed]
PHST- 2018/06/27 06:00 [medline]
PHST- 2017/10/14 06:00 [entrez]
AID - S0021-9150(17)31293-5 [pii]
AID - 10.1016/j.atherosclerosis.2017.09.022 [doi]
PST - ppublish
SO  - Atherosclerosis. 2017 Nov;266:145-150. doi: 
      10.1016/j.atherosclerosis.2017.09.022. Epub 2017 Sep 22.