PMID- 29028595
OWN - NLM
STAT- MEDLINE
DCOM- 20180412
LR  - 20181202
IS  - 1878-9307 (Electronic)
IS  - 1878-9293 (Print)
IS  - 1878-9293 (Linking)
VI  - 28
DP  - 2017 Dec
TI  - "Loser" or "Popular"?: Neural response to social status words in adolescents with 
      major depressive disorder.
PG  - 1-11
LID - S1878-9293(17)30058-0 [pii]
LID - 10.1016/j.dcn.2017.09.005 [doi]
AB  - Concerns about social status are ubiquitous during adolescence, with information 
      about social status often conveyed in text formats. Depressed adolescents may 
      show alterations in the functioning of neural systems supporting processing of 
      social status information. We examined whether depressed youth exhibited altered 
      neural activation to social status words in temporal and prefrontal cortical 
      regions thought to be involved in social cognitive processing, and whether this 
      response was associated with development. Forty-nine adolescents (ages 10-18; 35 
      female), including 20 with major depressive disorder and 29 controls, were 
      scanned while identifying the valence of words that connoted positive and 
      negative social status. Results indicated that depressed youth showed reduced 
      late activation to social status (vs neutral) words in the superior temporal 
      cortex (STC) and medial prefrontal cortex (MPFC); whereas healthy youth did not 
      show any significant differences between word types. Depressed youth also showed 
      reduced late activation in the dorsolateral prefrontal cortex and fusiform gyrus 
      to negative (vs positive) social status words; whereas healthy youth showed the 
      opposite pattern. Finally, age was positively associated with MPFC activation to 
      social status words. Findings suggest that hypoactivation in the "social 
      cognitive brain network" might be implicated in altered interpersonal functioning 
      in adolescent depression.
CI  - Copyright (c) 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Silk, Jennifer S
AU  - Silk JS
AD  - Department of Psychology, University of Pittsburgh, United States; Department of 
      Psychiatry, University of Pittsburgh School of Medicine, United States. 
      Electronic address: jss4@pitt.edu.
FAU - Lee, Kyung Hwa
AU  - Lee KH
AD  - Department of Psychology, University of Pittsburgh, United States.
FAU - Kerestes, Rebecca
AU  - Kerestes R
AD  - Department of Psychiatry, University of Pittsburgh School of Medicine, United 
      States.
FAU - Griffith, Julianne M
AU  - Griffith JM
AD  - Department of Psychology, University of Pittsburgh, United States.
FAU - Dahl, Ronald E
AU  - Dahl RE
AD  - School of Public Health, University of California, Berkeley, United States.
FAU - Ladouceur, Cecile D
AU  - Ladouceur CD
AD  - Department of Psychiatry, University of Pittsburgh School of Medicine, United 
      States; Department of Psychology, University of Pittsburgh, United States.
LA  - eng
GR  - R21 DA024144/DA/NIDA NIH HHS/United States
PT  - Journal Article
DEP - 20170923
PL  - Netherlands
TA  - Dev Cogn Neurosci
JT  - Developmental cognitive neuroscience
JID - 101541838
SB  - IM
MH  - Adolescent
MH  - Brain/*pathology
MH  - Child
MH  - Depressive Disorder, Major/*psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Neurons/*metabolism
PMC - PMC5783544
MID - NIHMS912508
OTO - NOTNLM
OT  - Adolescence
OT  - Depression
OT  - Neuroimaging
OT  - Social brain
OT  - Social status
EDAT- 2017/10/14 06:00
MHDA- 2018/04/13 06:00
PMCR- 2017/09/23
CRDT- 2017/10/14 06:00
PHST- 2017/03/13 00:00 [received]
PHST- 2017/09/13 00:00 [revised]
PHST- 2017/09/14 00:00 [accepted]
PHST- 2017/10/14 06:00 [pubmed]
PHST- 2018/04/13 06:00 [medline]
PHST- 2017/10/14 06:00 [entrez]
PHST- 2017/09/23 00:00 [pmc-release]
AID - S1878-9293(17)30058-0 [pii]
AID - 10.1016/j.dcn.2017.09.005 [doi]
PST - ppublish
SO  - Dev Cogn Neurosci. 2017 Dec;28:1-11. doi: 10.1016/j.dcn.2017.09.005. Epub 2017 
      Sep 23.