PMID- 29028824
OWN - NLM
STAT- MEDLINE
DCOM- 20171027
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 10
DP  - 2017
TI  - The association between serum brain-derived neurotrophic factor and a cluster of 
      cardiovascular risk factors in adolescents: The CHAMPS-study DK.
PG  - e0186384
LID - 10.1371/journal.pone.0186384 [doi]
LID - e0186384
AB  - BACKGROUND AND OBJECTIVE: Cardiovascular disease and type 2 diabetes pose a 
      global health burden. Therefore, clarifying the pathology of these risk factors 
      is essential. Previous studies have found positive and negative associations 
      between one or more cardiovascular risk factors and brain-derived neurotrophic 
      factor (BDNF) probably due to diverse methodological approaches when analysing 
      peripheral BDNF levels. Moreover, only a few studies have been performed in youth 
      populations. Consequently, the main objective of this study was to examine the 
      association between serum BDNF and a composite z-score consisting of six 
      cardiovascular risk factors. A secondary aim was to examine the associations 
      between serum BDNF and each of the six risk factors. METHODS: Four hundred and 
      forty-seven apparently healthy adolescents between 11-17 years of age 
      participated in this cross-sectional study. Cardiorespiratory fitness (CRF), 
      anthropometrics, pubertal status, blood pressure (BP), serum BDNF, high-density 
      lipoprotein cholesterol (HDL-C), triglyceride (TG), blood glucose and insulin 
      were measured. Information about alcohol consumption and socio-economic status 
      was collected via questionnaires. Associations were modelled using linear 
      regression analysis. RESULTS: Serum BDNF was positively associated with the 
      composite z-score in the total study sample (standardized beta coefficient 
      (std.beta) = 0.10, P = 0.037). In males, serum BDNF was positively associated with 
      the composite z-score (Std. beta = 0.14, P = 0.034) and HOMA-IR (Std. beta = 0.19, P = 
      0.004), and negatively associated with CRF (Std. beta = -0.15, P = 0.026). In 
      females, BDNF was positively associated with TG (Std. beta = 0.14, P = 0.030) and 
      negatively associated with waist circumference (WC) (Std. beta = -0.16, P = 0.012). 
      CONCLUSION: Serum BDNF was positively associated with a composite z-score of 
      cardiovascular risk factors. This association seems to be mainly driven by the 
      association between TG, HOMA-IR and serum BDNF, and particularly for males. 
      Further longitudinal research is warranted to determine the temporal relationship 
      between BDNF and cardiovascular risk factors.
FAU - Pedersen, Natascha Holbaek
AU  - Pedersen NH
AUID- ORCID: 0000-0003-4260-3240
AD  - Centre of Research in Childhood Health, Department of Sports Science and Clinical 
      Biomechanics, University of Southern Denmark, Odense, Denmark.
FAU - Tarp, Jakob
AU  - Tarp J
AD  - Centre of Research in Childhood Health, Department of Sports Science and Clinical 
      Biomechanics, University of Southern Denmark, Odense, Denmark.
FAU - Andersen, Lars Bo
AU  - Andersen LB
AD  - Department of Teacher Education and Sport, Western Norway University of Applied 
      Sciences, Campus Sogndal, Norway.
AD  - Norwegian School of Sport Sciences, Department of Sports Medicine, Oslo, Norway.
FAU - Gejl, Anne Kaer
AU  - Gejl AK
AD  - Centre of Research in Childhood Health, Department of Sports Science and Clinical 
      Biomechanics, University of Southern Denmark, Odense, Denmark.
FAU - Huang, Tao
AU  - Huang T
AD  - Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China.
FAU - Peijs, Lone
AU  - Peijs L
AD  - The Centre for Physical Activity Research, Department of Infectious Diseases, 
      Rigshospitalet, University of Copenhagen, Denmark.
FAU - Bugge, Anna
AU  - Bugge A
AD  - Centre of Research in Childhood Health, Department of Sports Science and Clinical 
      Biomechanics, University of Southern Denmark, Odense, Denmark.
LA  - eng
PT  - Journal Article
DEP - 20171013
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Lipoproteins, HDL)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adolescent
MH  - Blood Pressure
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cardiorespiratory Fitness
MH  - Cardiovascular Diseases/*blood/physiopathology
MH  - Female
MH  - Humans
MH  - Insulin Resistance
MH  - Lipoproteins, HDL/blood
MH  - Male
MH  - Risk Factors
MH  - Triglycerides/blood
MH  - Waist Circumference
PMC - PMC5640247
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/10/14 06:00
MHDA- 2017/10/28 06:00
PMCR- 2017/10/13
CRDT- 2017/10/14 06:00
PHST- 2017/06/28 00:00 [received]
PHST- 2017/09/30 00:00 [accepted]
PHST- 2017/10/14 06:00 [entrez]
PHST- 2017/10/14 06:00 [pubmed]
PHST- 2017/10/28 06:00 [medline]
PHST- 2017/10/13 00:00 [pmc-release]
AID - PONE-D-17-24418 [pii]
AID - 10.1371/journal.pone.0186384 [doi]
PST - epublish
SO  - PLoS One. 2017 Oct 13;12(10):e0186384. doi: 10.1371/journal.pone.0186384. 
      eCollection 2017.