PMID- 29029456
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 39
DP  - 2017 Sep 12
TI  - Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene single nucleotide 
      polymorphisms and its interaction with T2DM on pulmonary tuberculosis in Chinese 
      Uygur population.
PG  - 65601-65608
LID - 10.18632/oncotarget.19274 [doi]
AB  - AIMS: To investigate the association of several single nucleotide polymorphisms 
      (SNPs) within Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene and 
      additional gene- gene and gene- type 2 diabetes mellitus (T2DM) interaction with 
      pulmonary tuberculosis (PTB) risk in Chinese Uygur population. METHODS: A total 
      of 722 participants (186 males, 536 females) were selected, including 360 PTB 
      patients and 362 control participants. Generalized multifactor dimensionality 
      reduction (GMDR) was used to screen the best interaction combination among SNPs 
      and T2DM. Logistic regression was performed to investigate association between 3 
      SNPs within PTPN22 gene, additional gene- gene and gene- T2DM interaction on PTB 
      risk. RESULTS: Logistic regression analysis showed that PTB risk was 
      significantly lower in carriers with rs2476601- CT genotype than those with CC 
      genotype (CT versus CC), adjusted OR (95%CI) =0.42 (0.17-0.83), and higher in 
      carriers with the rs33996649- GA genotype than those with GG genotype (GA versus 
      GG), adjusted OR (95%CI) = 5.66 (2.24-9.47). We found a significant two-locus 
      model (p=0.0010) involving rs33996649 and T2DM. Overall, the cross-validation 
      consistency of this two- locus model was 10/ 10, and the testing accuracy was 
      60.11%. We also conducted stratified analysis for rs33996649 and T2DM using 
      logistic regression. We found that T2DM patients with rs33996649 - GA genotype 
      have the highest PTB risk, compared to non- T2DM patients with rs33996649- GG 
      genotype, OR (95%CI) = 4.52 (2.71 -6.43), after covariates adjustment. 
      CONCLUSIONS: We found that the T allele of rs2476601 and the A allele of 
      rs33996649within PTPN22 gene, interaction between rs2476601 and T2DM were all 
      associated with increased PTB risk.
FAU - Wang, Xian-Hua
AU  - Wang XH
AD  - The School of Public Health, Medical College of Qingdao University, Qingdao, P.R 
      China.
FAU - Ma, Ai-Guo
AU  - Ma AG
AD  - The School of Public Health, Medical College of Qingdao University, Qingdao, P.R 
      China.
FAU - Han, Xiu-Xia
AU  - Han XX
AD  - The School of Public Health, Medical College of Qingdao University, Qingdao, P.R 
      China.
FAU - Chen, Lei
AU  - Chen L
AD  - The School of Public Health, Medical College of Qingdao University, Qingdao, P.R 
      China.
FAU - Liang, Hui
AU  - Liang H
AD  - The School of Public Health, Medical College of Qingdao University, Qingdao, P.R 
      China.
FAU - Aishan-Litifu
AU  - Aishan-Litifu
AD  - Department of Respiratory Medicine, Xinjiang Uygur Autonomous Region Chest 
      Hospital, The Xinjiang Uygur Autonomous Region, Urumqi, P.R China.
FAU - Abudumijit-Ablez
AU  - Abudumijit-Ablez
AD  - Department of Respiratory Medicine, Xinjiang Uygur Autonomous Region Chest 
      Hospital, The Xinjiang Uygur Autonomous Region, Urumqi, P.R China.
FAU - Xue, Feng
AU  - Xue F
AD  - Tuberculosis Department of The Xinjiang Uygur Autonomous Region Center for 
      Disease Control and Prevention, The Xinjiang Uygur Autonomous Region, Urumqi, P. 
      R China.
LA  - eng
PT  - Journal Article
DEP - 20170715
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
PMC - PMC5630356
OTO - NOTNLM
OT  - PTPN22
OT  - T2DM
OT  - interaction
OT  - pulmonary tuberculosis
OT  - single nucleotide polymorphisms
COIS- CONFLICTS OF INTEREST None.
EDAT- 2017/10/17 06:00
MHDA- 2017/10/17 06:01
PMCR- 2017/09/12
CRDT- 2017/10/15 06:00
PHST- 2017/03/13 00:00 [received]
PHST- 2017/04/23 00:00 [accepted]
PHST- 2017/10/15 06:00 [entrez]
PHST- 2017/10/17 06:00 [pubmed]
PHST- 2017/10/17 06:01 [medline]
PHST- 2017/09/12 00:00 [pmc-release]
AID - 19274 [pii]
AID - 10.18632/oncotarget.19274 [doi]
PST - epublish
SO  - Oncotarget. 2017 Jul 15;8(39):65601-65608. doi: 10.18632/oncotarget.19274. 
      eCollection 2017 Sep 12.