PMID- 29030174
OWN - NLM
STAT- MEDLINE
DCOM- 20180911
LR  - 20180911
IS  - 1096-0007 (Electronic)
IS  - 0014-4835 (Linking)
VI  - 166
DP  - 2018 Jan
TI  - Growth hormone protects against kainate excitotoxicity and induces BDNF and NT3 
      expression in chicken neuroretinal cells.
PG  - 1-12
LID - S0014-4835(17)30410-4 [pii]
LID - 10.1016/j.exer.2017.10.005 [doi]
AB  - There is increasing evidence to suggest a beneficial neuroprotective effect of 
      growth hormone (GH) in the nervous system. While our previous studies have 
      largely focused on retinal ganglion cells (RGCs), we have also found conclusive 
      evidence of a pro-survival effect of GH in cells of the inner nuclear layer (INL) 
      as well as a protective effect on the dendritic trees of the inner plexiform 
      layer (IPL) in the retina. The administration of GH in primary neuroretinal cell 
      cultures protected and induced neural outgrowths. Our results, both in vitro 
      (embryo) and in vivo (postnatal), showed neuroprotective actions of GH against 
      kainic acid (KA)-induced excitotoxicity in the chicken neuroretina. Intravitreal 
      injections of GH restored brain derived neurotrophic factor (BDNF) expression in 
      retinas treated with KA. In addition, we demonstrated that GH over-expression and 
      exogenous administration increased BDNF and neurotrophin-3 (NT3) gene expression 
      in embryonic neuroretinal cells. Thus, GH neuroprotective actions in neural 
      tissues may be mediated by a complex cascade of neurotrophins and growth factors 
      which have been classically related to damage prevention and neuroretinal tissue 
      repair.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Martinez-Moreno, C G
AU  - Martinez-Moreno CG
AD  - Departamento de Neurobiologia Celular y Molecular, Instituto de Neurobiologia, 
      Campus Juriquilla, Universidad Nacional Autonoma de Mexico, Queretaro, Qro., 
      76230, Mexico. Electronic address: cgmartin@comunidad.unam.mx.
FAU - Fleming, T
AU  - Fleming T
AD  - Department of Physiology, University of Alberta, Edmonton, T6G 2H7, Canada.
FAU - Carranza, M
AU  - Carranza M
AD  - Departamento de Neurobiologia Celular y Molecular, Instituto de Neurobiologia, 
      Campus Juriquilla, Universidad Nacional Autonoma de Mexico, Queretaro, Qro., 
      76230, Mexico.
FAU - Avila-Mendoza, J
AU  - Avila-Mendoza J
AD  - Departamento de Neurobiologia Celular y Molecular, Instituto de Neurobiologia, 
      Campus Juriquilla, Universidad Nacional Autonoma de Mexico, Queretaro, Qro., 
      76230, Mexico.
FAU - Luna, M
AU  - Luna M
AD  - Departamento de Neurobiologia Celular y Molecular, Instituto de Neurobiologia, 
      Campus Juriquilla, Universidad Nacional Autonoma de Mexico, Queretaro, Qro., 
      76230, Mexico.
FAU - Harvey, S
AU  - Harvey S
AD  - Department of Physiology, University of Alberta, Edmonton, T6G 2H7, Canada.
FAU - Aramburo, C
AU  - Aramburo C
AD  - Departamento de Neurobiologia Celular y Molecular, Instituto de Neurobiologia, 
      Campus Juriquilla, Universidad Nacional Autonoma de Mexico, Queretaro, Qro., 
      76230, Mexico.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171010
PL  - England
TA  - Exp Eye Res
JT  - Experimental eye research
JID - 0370707
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Neurotrophin 3)
RN  - 9002-72-6 (Growth Hormone)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Chickens
MH  - Disease Models, Animal
MH  - Excitatory Amino Acid Agonists/*pharmacology
MH  - Growth Hormone/*pharmacology
MH  - Kainic Acid/*pharmacology
MH  - Neuroprotection/drug effects
MH  - Neuroprotective Agents/*pharmacology
MH  - Neurotrophin 3/*metabolism
MH  - Retina/*drug effects/embryology/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
OTO - NOTNLM
OT  - Excitotoxicity
OT  - Growth hormone
OT  - Kainate
OT  - Neuro-regeneration
OT  - Neuroprotection
OT  - Neuroretina
OT  - Neurotrophins
EDAT- 2017/10/17 06:00
MHDA- 2018/09/12 06:00
CRDT- 2017/10/15 06:00
PHST- 2017/06/05 00:00 [received]
PHST- 2017/08/07 00:00 [revised]
PHST- 2017/10/08 00:00 [accepted]
PHST- 2017/10/17 06:00 [pubmed]
PHST- 2018/09/12 06:00 [medline]
PHST- 2017/10/15 06:00 [entrez]
AID - S0014-4835(17)30410-4 [pii]
AID - 10.1016/j.exer.2017.10.005 [doi]
PST - ppublish
SO  - Exp Eye Res. 2018 Jan;166:1-12. doi: 10.1016/j.exer.2017.10.005. Epub 2017 Oct 
      10.