PMID- 29030221
OWN - NLM
STAT- MEDLINE
DCOM- 20190222
LR  - 20190222
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 675
DP  - 2018 May 14
TI  - Inhibition of BDNF production by MPP(+) through up-regulation of miR-210-3p 
      contributes to dopaminergic neuron damage in MPTP model.
PG  - 133-139
LID - S0304-3940(17)30832-7 [pii]
LID - 10.1016/j.neulet.2017.10.014 [doi]
AB  - The neurotrophin brain-derived neurotrophic factor (BDNF) has been involved in 
      supporting of neuron survival. The observation of reduced level of BDNF in the 
      substantia nigra (SN) of Parkinson's disease (PD) patients suggests its important 
      role in neuron protection in PD pathogenesis. However, the mechanism underlying 
      the down-regulation of BDNF in PD was largely unknown. In this study, we found 
      that miR-210-3p is involved in the regulation of BDNF production by 
      1-methyl-4-phenylpyridinium (MPP(+)). MPP(+) inhibits the BDNF production in 
      SH-SY5Y cells through a transcription independent manner. Moreover, miR-210-3p, 
      which targets BDNF mRNA, is up-regulated by MPP(+) in SH-SY5Y cells. Importantly, 
      inhibition of miR-210-3p prevents the reduction of BDNF production by MPP(+) and 
      improves the DA neuron survival in 1-methyl-4-phenyl-1,2,3,6-tetra hydropyridine 
      (MPTP) model. Together, we demonstrated up-regulation of miR-210-3p by MPP(+) 
      reduces the BDNF production and contributes to the DA neuron damage.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Zhang, Shan
AU  - Zhang S
AD  - Department of Neurology, The People's Hospital of Leshan, Leshan 614000, Sichuan, 
      China.
FAU - Chen, Shu
AU  - Chen S
AD  - Department of Neurosurgery, The People's Hospital of Leshan, Leshan 614000, 
      Sichuan, China.
FAU - Liu, Anmin
AU  - Liu A
AD  - Department of Neurosurgery, SunYat-sen Memorial Hospital, SunYat-sen University, 
      Guangzhou 510120, Guangdong, China.
FAU - Wan, Jungang
AU  - Wan J
AD  - Department of Neurology, The People's Hospital of Leshan, Leshan 614000, Sichuan, 
      China.
FAU - Tang, Lingwen
AU  - Tang L
AD  - Department of Neurology, The People's Hospital of Leshan, Leshan 614000, Sichuan, 
      China.
FAU - Zheng, Niandong
AU  - Zheng N
AD  - Department of Neurosurgery, The People's Hospital of Leshan, Leshan 614000, 
      Sichuan, China.
FAU - Xiong, Yi
AU  - Xiong Y
AD  - Department of Neurology, The People's Hospital of Leshan, Leshan 614000, Sichuan, 
      China. Electronic address: xiongyixiaoyan@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171013
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Bdnf protein, mouse)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (MIRN210 microRNA, human)
RN  - 0 (MIRN210 microRNA, mouse)
RN  - 0 (MicroRNAs)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - R865A5OY8J (1-Methyl-4-phenylpyridinium)
SB  - IM
MH  - 1-Methyl-4-phenylpyridinium/*administration & dosage
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cell Line, Tumor
MH  - Dopaminergic Neurons/drug effects/*metabolism/pathology
MH  - Down-Regulation
MH  - Humans
MH  - Mice, Inbred C57BL
MH  - MicroRNAs/*metabolism
MH  - Parkinson Disease/*metabolism
MH  - Parkinsonian Disorders/metabolism
MH  - Up-Regulation
OTO - NOTNLM
OT  - BDNF
OT  - MPP(+)
OT  - Neuron damage
OT  - Parkinson's disease
OT  - miR-210-3p
EDAT- 2017/10/17 06:00
MHDA- 2019/02/23 06:00
CRDT- 2017/10/15 06:00
PHST- 2017/04/25 00:00 [received]
PHST- 2017/10/08 00:00 [revised]
PHST- 2017/10/09 00:00 [accepted]
PHST- 2017/10/17 06:00 [pubmed]
PHST- 2019/02/23 06:00 [medline]
PHST- 2017/10/15 06:00 [entrez]
AID - S0304-3940(17)30832-7 [pii]
AID - 10.1016/j.neulet.2017.10.014 [doi]
PST - ppublish
SO  - Neurosci Lett. 2018 May 14;675:133-139. doi: 10.1016/j.neulet.2017.10.014. Epub 
      2017 Oct 13.