PMID- 29030378
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20191023
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 2017
DP  - 2017 Oct 13
TI  - Worsening Guillain-Barre syndrome: harbinger of IRIS in HIV?
LID - bcr-2017-221874 [pii]
LID - 10.1136/bcr-2017-221874 [doi]
LID - bcr2017221874
AB  - We report an HIV patient aged 38 years with acute inflammatory demyelinating 
      polyradiculoneuropathy subtype of Guillain-Barre syndrome (GBS) as the only 
      manifestation of seroconversion and worsening of GBS being the harbinger of 
      immune reconstitution inflammatory syndrome (IRIS). To date, only 5 cases of GBS 
      during IRIS are reported. They manifested either during the third week or later 
      after starting highly active antiretroviral therapy (HAART). Our patient 
      witnessed worsening weakness by fifth day after starting HAART, even before the 
      occurrence of Pneumocystis jirovecii pneumonia, cautioning one of the impending 
      serious complications of IRIS and helped us initiate steroids at an early date.
CI  - (c) BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 
      2017. All rights reserved. No commercial use is permitted unless otherwise 
      expressly granted.
FAU - Mathukumalli, Neeharika L
AU  - Mathukumalli NL
AUID- ORCID: 0000-0001-8454-1485
AD  - Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, 
      Telangana, India.
FAU - Ali, Niloufer
AU  - Ali N
AD  - Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, 
      Telangana, India.
FAU - Kanikannan, Meena A
AU  - Kanikannan MA
AD  - Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, 
      Telangana, India.
FAU - Yareeda, Sireesha
AU  - Yareeda S
AD  - Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, 
      Telangana, India.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20171013
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Antiretroviral Therapy, Highly Active
MH  - CD4 Lymphocyte Count
MH  - Diagnosis, Differential
MH  - Guillain-Barre Syndrome/complications/*diagnosis/physiopathology
MH  - HIV Infections/complications/*diagnosis/drug therapy
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/complications/*diagnosis/drug therapy
MH  - Male
MH  - Methylprednisolone/administration & dosage/therapeutic use
MH  - Middle Aged
PMC - PMC5652629
COIS- Competing interests: None declared.
EDAT- 2017/10/17 06:00
MHDA- 2018/06/05 06:00
PMCR- 2019/10/13
CRDT- 2017/10/15 06:00
PHST- 2017/10/15 06:00 [entrez]
PHST- 2017/10/17 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
PHST- 2019/10/13 00:00 [pmc-release]
AID - bcr-2017-221874 [pii]
AID - 10.1136/bcr-2017-221874 [doi]
PST - epublish
SO  - BMJ Case Rep. 2017 Oct 13;2017:bcr2017221874. doi: 10.1136/bcr-2017-221874.