PMID- 29030687
OWN - NLM
STAT- MEDLINE
DCOM- 20190313
LR  - 20190313
IS  - 1432-1750 (Electronic)
IS  - 0341-2040 (Linking)
VI  - 196
IP  - 1
DP  - 2018 Feb
TI  - Tolerability of Bisoprolol on Domiciliary Spirometry in COPD.
PG  - 11-14
LID - 10.1007/s00408-017-0061-y [doi]
AB  - We investigated if serial domiciliary measures of spirometry were sensitive at 
      detecting subtle effects of beta-2 blockade associated with bisoprolol in 
      (n = 17) patients with COPD. After a two-week run in on inhaled corticosteroid 
      (ICS) and long acting beta-2 agonist (LABA): beclometasone/formoterol 100/6 microg, 
      patients' started additional a long acting muscarinic receptor antagonist: (LAMA) 
      Tiotropium 18 microg, with concomitant weekly dose titration of bisoprolol: 
      1.25-2.5-5 mg. After a further week of bisoprolol 5 mg, they were stepped back 
      down to (ICS/LABA) for one week. Mean age was 64 years, mean FEV(1) 52% 
      predicted, and mean FEV(1)/FVC ratio of 0.46. Compared to baseline am FEV(1) of 
      1.38 L (95% CI 1.14-1.61 L), both ICS/LABA/LAMA and ICS/LABA in conjunction with 
      bisoprolol showed statistically significant mean falls of 100 ml (1.28 L, 95% CI 
      1.03-1.53 L), and 120 ml, respectively (1.26 L, 95% CI 1.01-1.51 L); equalling 
      and exceeding the MCID of 100 ml, respectively. These changes were disconnected 
      from symptoms, reliever use and oxygen saturation.
FAU - Jabbal, Sunny
AU  - Jabbal S
AD  - Scottish Centre for Respiratory Research, Division of Molecular and Clinical 
      Medicine, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, UK.
FAU - Lipworth, Brian J
AU  - Lipworth BJ
AD  - Scottish Centre for Respiratory Research, Division of Molecular and Clinical 
      Medicine, Ninewells Hospital and Medical School, Dundee, Scotland, DD1 9SY, UK. 
      b.j.lipworth@dundee.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171014
PL  - United States
TA  - Lung
JT  - Lung
JID - 7701875
RN  - 0 (Adrenergic beta-1 Receptor Antagonists)
RN  - 0 (Adrenergic beta-2 Receptor Agonists)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Muscarinic Antagonists)
RN  - KGZ1SLC28Z (Beclomethasone)
RN  - S88TT14065 (Oxygen)
RN  - W34SHF8J2K (Formoterol Fumarate)
RN  - XX112XZP0J (Tiotropium Bromide)
RN  - Y41JS2NL6U (Bisoprolol)
SB  - IM
MH  - Administration, Inhalation
MH  - Adrenergic beta-1 Receptor Antagonists/*adverse effects
MH  - Adrenergic beta-2 Receptor Agonists/administration & dosage
MH  - Anti-Inflammatory Agents/administration & dosage
MH  - Beclomethasone/administration & dosage
MH  - Bisoprolol/*adverse effects
MH  - Drug Therapy, Combination
MH  - Female
MH  - Forced Expiratory Volume/drug effects
MH  - Formoterol Fumarate/administration & dosage
MH  - Heart Rate/drug effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscarinic Antagonists/therapeutic use
MH  - Oxygen/blood
MH  - Pulmonary Disease, Chronic Obstructive/*drug therapy/*physiopathology
MH  - Spirometry/*methods
MH  - Tiotropium Bromide/therapeutic use
MH  - Vital Capacity/drug effects
OTO - NOTNLM
OT  - Beta blocker
OT  - COPD
OT  - FEV1
OT  - FEV6
OT  - Spirometry
EDAT- 2017/10/17 06:00
MHDA- 2019/03/14 06:00
CRDT- 2017/10/15 06:00
PHST- 2017/07/27 00:00 [received]
PHST- 2017/10/05 00:00 [accepted]
PHST- 2017/10/17 06:00 [pubmed]
PHST- 2019/03/14 06:00 [medline]
PHST- 2017/10/15 06:00 [entrez]
AID - 10.1007/s00408-017-0061-y [pii]
AID - 10.1007/s00408-017-0061-y [doi]
PST - ppublish
SO  - Lung. 2018 Feb;196(1):11-14. doi: 10.1007/s00408-017-0061-y. Epub 2017 Oct 14.