PMID- 29031144
OWN - NLM
STAT- MEDLINE
DCOM- 20180723
LR  - 20180723
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 53
DP  - 2017 Dec
TI  - Senegenin exerts anti-depression effect in mice induced by chronic un-predictable 
      mild stress via inhibition of NF-kappaB regulating NLRP3 signal pathway.
PG  - 24-32
LID - S1567-5769(17)30370-3 [pii]
LID - 10.1016/j.intimp.2017.10.001 [doi]
AB  - Depressive disorder is a kind of affective disturbance disease. Emerging evidence 
      has suggested that inflammation may contribute to the pathologic process of 
      depressive disorder. Senegenin (SEN), a major bioactive constituent in Polygala 
      tenuifolia Willd, has much bioactivity including anti-inflammatory and 
      neuroprotection effects. However, the mechanism of its anti-depressant effect in 
      mice remains unknown. This study aimed to explore the anti-depressant effects of 
      SEN on behavioral changes and inflammatory responses in mice induced by chronic 
      un-predictable mild stress (CUMS). SEN treatment remarkably ameliorated 
      CUMS-induced behavioral abnormalities, such as improving locomotor activity, 
      decreasing immobility time in Tail suspension test (TST) and Forced swimming test 
      (FST), and increasing sucrose intake in Sucrose preference test (SPT). 
      Additionally, SEN improve protein levels of Brain-derived neurotrophic factor 
      (BDNF) and Neurotrophin-3 (NT-3) expression. In response to stress, p65 was 
      activated to promote production of pro-IL-1beta, and then cleaved to mature IL-1beta by 
      NOD-like receptor protein 3 (NLRP3) inflammasome pathway in hippocampus of CUMS 
      mice. After SEN treatment, protein activation related to NLRP3 inflammasome 
      pathway was down-regulated, which inhibited IL-1beta secretion. These results 
      demonstrate that SEN plays an important role in treatment CUMS-induced depression 
      in mice, possibly via suppression of pathway activation associated with NLRP3 
      inflammasome.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Li, Hongwei
AU  - Li H
AD  - Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical 
      University, Nanjing 210009, PR China.
FAU - Lin, Shiyi
AU  - Lin S
AD  - Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical 
      University, Nanjing 210009, PR China.
FAU - Qin, Tingting
AU  - Qin T
AD  - Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical 
      University, Nanjing 210009, PR China.
FAU - Li, Hongyan
AU  - Li H
AD  - Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical 
      University, Nanjing 210009, PR China.
FAU - Ma, Zhanqiang
AU  - Ma Z
AD  - Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical 
      University, Nanjing 210009, PR China. Electronic address: 
      mazhanqiang0427@163.com.
FAU - Ma, Shiping
AU  - Ma S
AD  - Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical 
      University, Nanjing 210009, PR China. Electronic address: spma@cpu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20171012
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Inflammasomes)
RN  - 0 (Interleukin-1beta)
RN  - 0 (NF-kappa B)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (Neurotrophin 3)
RN  - 0 (Nlrp3 protein, mouse)
RN  - 06S1QH951L (tenuigenin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Antidepressive Agents/*therapeutic use
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Depressive Disorder/*drug therapy
MH  - Disease Models, Animal
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Humans
MH  - Inflammasomes/metabolism
MH  - Inflammation/*drug therapy
MH  - Interleukin-1beta/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - NF-kappa B/metabolism
MH  - NLR Family, Pyrin Domain-Containing 3 Protein/metabolism
MH  - Neuroprotection
MH  - Neurotrophin 3/metabolism
MH  - Polygala/immunology
MH  - Signal Transduction
MH  - Stress, Psychological/*drug therapy
OTO - NOTNLM
OT  - Chronic unpredictable mild stress
OT  - Depression
OT  - Hippocampus
OT  - Inflammation
OT  - Senegenin
EDAT- 2017/10/17 06:00
MHDA- 2018/07/24 06:00
CRDT- 2017/10/15 06:00
PHST- 2017/04/07 00:00 [received]
PHST- 2017/09/22 00:00 [revised]
PHST- 2017/10/01 00:00 [accepted]
PHST- 2017/10/17 06:00 [pubmed]
PHST- 2018/07/24 06:00 [medline]
PHST- 2017/10/15 06:00 [entrez]
AID - S1567-5769(17)30370-3 [pii]
AID - 10.1016/j.intimp.2017.10.001 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2017 Dec;53:24-32. doi: 10.1016/j.intimp.2017.10.001. Epub 
      2017 Oct 12.