PMID- 29032417
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20181113
IS  - 1863-4362 (Electronic)
IS  - 0021-1265 (Linking)
VI  - 187
IP  - 2
DP  - 2018 May
TI  - Clinical evaluation for sublingual immunotherapy with Dermatophagoides farinae 
      drops in adult patients with allergic asthma.
PG  - 441-446
LID - 10.1007/s11845-017-1685-x [doi]
AB  - PURPOSE: The efficacy and safety of sublingual immunotherapy (SLIT) in house dust 
      mite-induced allergic asthma (AA) have yet to be firmly established, especially 
      in adult patients. Our objective is to evaluate the efficacy of SLIT with 
      Dermatophagoides farinae drops in adult patients with AA. METHODS: One hundred 
      and thirty-four adult patient data with house dust mite (HDM)-induced AA who had 
      been treated for 2 years were collected. These patient data that we collected 
      were divided into the SLIT group (n = 85) and control group (n = 49). All 
      patients were treated with low to moderate dose of inhaled glucocorticoid and 
      long-acting beta2 agonists. Patients in the SLIT group were further treated with D. 
      farinae drops. Clinical scores including the total asthma symptom score (TASS), 
      total asthma medicine score (TAMS), asthma control test (ACT), and peak flow 
      percentage (PEF%) were assessed before treatment and at yearly visits. The 
      presence of adverse events (AEs) were recorded once a month. RESULTS: Before 
      treatment, the PEF% in the SLIT group was significantly lower than that in the 
      control group (p < 0.05). After 2 years, both treatments were effective in the 
      clinical scores when compared with baseline values (all p < 0.001). Meanwhile, 
      the SLIT group showed significantly lower TASS and TAMS (all p < 0.001) and 
      higher ACT (p < 0.001) and PEF% (p < 0.05) when compared with the control group. 
      No severe systemic AEs were reported. CONCLUSIONS: SLIT with D. farinae drops 
      plus pharmacotherapy is more effective than routine drug treatment in adult 
      patients with AA.
FAU - Zhong, C
AU  - Zhong C
AD  - Department of Respiratory, Wuzhou Red Cross Hospital, No.1-3 Xinxingyi road, 
      Dieshan district, Wuzhou, 543002, China. zhongcan2016@163.com.
FAU - Yang, W
AU  - Yang W
AD  - Department of Respiratory, Wuzhou Red Cross Hospital, No.1-3 Xinxingyi road, 
      Dieshan district, Wuzhou, 543002, China.
FAU - Li, Y
AU  - Li Y
AD  - Department of Respiratory, Wuzhou Red Cross Hospital, No.1-3 Xinxingyi road, 
      Dieshan district, Wuzhou, 543002, China.
FAU - Zou, L
AU  - Zou L
AD  - Department of Respiratory, Wuzhou Red Cross Hospital, No.1-3 Xinxingyi road, 
      Dieshan district, Wuzhou, 543002, China.
FAU - Deng, Z
AU  - Deng Z
AD  - Department of Respiratory, Wuzhou Red Cross Hospital, No.1-3 Xinxingyi road, 
      Dieshan district, Wuzhou, 543002, China.
FAU - Liu, M
AU  - Liu M
AD  - Department of Respiratory, Wuzhou Red Cross Hospital, No.1-3 Xinxingyi road, 
      Dieshan district, Wuzhou, 543002, China.
FAU - Huang, X
AU  - Huang X
AD  - Department of Respiratory, Wuzhou Red Cross Hospital, No.1-3 Xinxingyi road, 
      Dieshan district, Wuzhou, 543002, China.
LA  - eng
GR  - 201202081/department of science and technology project of Wuzhou city Guangxi 
      Province, China/
PT  - Journal Article
DEP - 20171014
PL  - Ireland
TA  - Ir J Med Sci
JT  - Irish journal of medical science
JID - 7806864
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Asthma/*drug therapy
MH  - Dermatophagoides farinae/*pathogenicity
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sublingual Immunotherapy/*methods
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Adult patient
OT  - Allergic asthma
OT  - Sublingual immunotherapy
EDAT- 2017/10/17 06:00
MHDA- 2018/06/05 06:00
CRDT- 2017/10/17 06:00
PHST- 2017/02/23 00:00 [received]
PHST- 2017/10/03 00:00 [accepted]
PHST- 2017/10/17 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
PHST- 2017/10/17 06:00 [entrez]
AID - 10.1007/s11845-017-1685-x [pii]
AID - 10.1007/s11845-017-1685-x [doi]
PST - ppublish
SO  - Ir J Med Sci. 2018 May;187(2):441-446. doi: 10.1007/s11845-017-1685-x. Epub 2017 
      Oct 14.