PMID- 29032460
OWN - NLM
STAT- MEDLINE
DCOM- 20180611
LR  - 20181113
IS  - 1432-1831 (Electronic)
IS  - 0300-8584 (Linking)
VI  - 206
IP  - 6
DP  - 2017 Dec
TI  - The impact of KIR-HLA genotype on hepatitis B virus clearance in Iranian infected 
      individuals.
PG  - 463-470
LID - 10.1007/s00430-017-0522-1 [doi]
AB  - Killer cell immunoglobulin like receptors (KIRs) have a principal role in 
      regulating the effector functions of NK cells, particularly in viral infections. 
      The major ligands for KIRs are human leukocyte antigen (HLA) class I molecules. 
      The aim of this study is to investigate the possible association of KIR genes, 
      their known HLA ligands and compound KIR-HLA genotypes with hepatitis B virus 
      (HBV) infection. Our study group consisted of 202 Iranian HBV-infected patients 
      (52 spontaneously recovered, 50 asymptomatic carriers, 50 chronic sufferers and 
      50with liver cirrhosis) and 100 ethnic-matched healthy control subjects. KIR and 
      HLA genotyping was performed by a polymerase chain reaction-sequence-specific 
      primer (PCR-SSP). The frequencies of the KIR2DL5A, KIR2DS1, and KIR3DS1 genes 
      were significantly elevated in recovered individuals when compared with both 
      control and patient groups. Also, KIR2DL5, and KIR3DP1 full were escalated in 
      recovered individuals in comparison with patient groups. In addition, HLA-Bw4 
      ligand and HLA-A Bw4 were highly frequent in recovered individuals compared with 
      healthy controls. Furthermore, the KIR3DS1 + HLA-Bw4, KIR3DS1 + HLA-Bw4 (Iso80) , 
      and KIR3DS1 + HLA-A Bw4 genotypes were significantly more common in recovered 
      individuals than both healthy control and patient groups. Interestingly, AA 
      genotype had less frequency and Bx had higher frequency in recovered individuals 
      compared with both healthy control and patient groups. Our findings suggest a 
      potential impact of the NK cells' activating phenotype that leads to the HBV 
      clearance in infected individuals.
FAU - Shah-Hosseini, Alireza
AU  - Shah-Hosseini A
AD  - Immunology Research Center (IRC), Institute of Immunology and Infectious Disease, 
      Iran University of Medical Sciences, Tehran, Iran.
FAU - Jafari, Mohammad
AU  - Jafari M
AD  - Immunology Research Center (IRC), Institute of Immunology and Infectious Disease, 
      Iran University of Medical Sciences, Tehran, Iran.
AD  - Cellular and Molecular Research Center, Gerash University of Medical Science, 
      Gerash, Iran.
FAU - Mohammadi, Asadollah
AU  - Mohammadi A
AD  - Immunology Research Center (IRC), Institute of Immunology and Infectious Disease, 
      Iran University of Medical Sciences, Tehran, Iran.
AD  - Inflammation and Inflammatory Disease Research Center, Faculty of Medicine, 
      Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Sanaei, Roozbeh
AU  - Sanaei R
AD  - Immunology Research Center (IRC), Institute of Immunology and Infectious Disease, 
      Iran University of Medical Sciences, Tehran, Iran.
FAU - Alavian, Seyed Moayed
AU  - Alavian SM
AD  - Baqiyatallah Research Center for Gastroenterology and Liver Diseases, 
      Baqiyatallah University of Medical Sciences, Tehran, Iran.
FAU - Doosti-Irani, Amin
AU  - Doosti-Irani A
AD  - Department of Epidemiology, School of Public Health, Hamadan University of 
      Medical Science, Hamadan, Iran.
FAU - Nooradeh Keykavousi, Mehrnoush
AU  - Nooradeh Keykavousi M
AD  - Department of Microbiology, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Tajik, Nader
AU  - Tajik N
AD  - Immunology Research Center (IRC), Institute of Immunology and Infectious Disease, 
      Iran University of Medical Sciences, Tehran, Iran. tajik.n@iums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20171014
PL  - Germany
TA  - Med Microbiol Immunol
JT  - Medical microbiology and immunology
JID - 0314524
RN  - 0 (La protein, human)
RN  - 0 (Phosphoproteins)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Adult
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - *Genotype
MH  - Genotyping Techniques
MH  - Hepatitis B/*genetics
MH  - Humans
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - Phosphoproteins/*genetics
MH  - Polymerase Chain Reaction
MH  - Receptors, KIR/*genetics
MH  - Young Adult
OTO - NOTNLM
OT  - Genotyping
OT  - HBV infection
OT  - HLA ligand genes
OT  - KIR genes
OT  - NK cells
EDAT- 2017/10/17 06:00
MHDA- 2018/06/12 06:00
CRDT- 2017/10/17 06:00
PHST- 2017/07/02 00:00 [received]
PHST- 2017/09/21 00:00 [accepted]
PHST- 2017/10/17 06:00 [pubmed]
PHST- 2018/06/12 06:00 [medline]
PHST- 2017/10/17 06:00 [entrez]
AID - 10.1007/s00430-017-0522-1 [pii]
AID - 10.1007/s00430-017-0522-1 [doi]
PST - ppublish
SO  - Med Microbiol Immunol. 2017 Dec;206(6):463-470. doi: 10.1007/s00430-017-0522-1. 
      Epub 2017 Oct 14.