PMID- 29032589
OWN - NLM
STAT- MEDLINE
DCOM- 20180822
LR  - 20180822
IS  - 1868-6982 (Electronic)
IS  - 1868-6974 (Linking)
VI  - 24
IP  - 12
DP  - 2017 Dec
TI  - Microscopic assessment of the tissue-sparing potential of radiofrequency-assisted 
      liver resection techniques in a porcine model.
PG  - 657-666
LID - 10.1002/jhbp.513 [doi]
AB  - BACKGROUND: The aim of the present study was to microscopically assess the 
      tissue-sparing potential of contemporary radiofrequency-assisted liver resection 
      (RF-LR) techniques. METHODS: Twenty-four pigs were subjected to either (1) 
      partial hepatectomy (PH) using the sequential-coagulate-cut (SCC) technique 
      (group SCC, n = 6) using a monopolar electrode, the technique using the bipolar 
      electrode Habib-4X (group H, n = 6) or the "crush-clamp" technique (group CC, n = 
      6); or (2) sham operation (group Sham, n = 6). At 48 h post-operation, liver 
      parenchyma proximal to the ablation rim was excised for histopathologic 
      examination and immunohistochemical assessment of apoptosis (antibody M30) and 
      inflammatory response (antibodies IL-6, TNFalpha and NFkappaB). RESULTS: Histopathologic 
      index increased from the 1(st) to the 4(th) , the 1(st) to the 2(nd) or only the 
      1(st) cm from the inner margin of the ablation rim in group SCC, H or CC, 
      respectively. The index was higher in group SCC compared to the other groups. 
      Tissue expression of M30, IL-6, TNFalpha and NFkappaB increased in all PH groups, being 
      higher and more expanded in group SCC, H, SCC and SCC, respectively. CONCLUSIONS: 
      RF-LR techniques had variable microscopically assessed tissue-sparing effect. The 
      Habib-4X proved to be less injurious compared to the SCC Belgrade technique 
      regarding the severity and extent of tissue damage proximal to the ablation rim.
CI  - (c) 2017 Japanese Society of Hepato-Biliary-Pancreatic Surgery.
FAU - Ypsilantis, Petros
AU  - Ypsilantis P
AD  - Laboratory of Experimental Surgery and Surgical Research, School of Medicine, 
      Democritus University of Thrace, Alexandroupolis, Greece.
FAU - Lambropoulou, Maria
AU  - Lambropoulou M
AD  - Laboratory of Histology and Embryology, School of Medicine, Democritus University 
      of Thrace, Alexandroupolis, Greece.
FAU - Milicevic, Miroslav
AU  - Milicevic M
AD  - First Surgical Clinic, School of Medicine, University of Belgrade, Belgrade, 
      Serbia.
FAU - Bulajic, Predrag
AU  - Bulajic P
AD  - First Surgical Clinic, School of Medicine, University of Belgrade, Belgrade, 
      Serbia.
FAU - Karayiannakis, Anastasios
AU  - Karayiannakis A
AD  - Laboratory of Experimental Surgery and Surgical Research, School of Medicine, 
      Democritus University of Thrace, Alexandroupolis, Greece.
FAU - Zacharoulis, Dimitrios
AU  - Zacharoulis D
AD  - Clinic of Surgery, School of Medicine, University of Thessaly, University 
      Hospital of Larissa, Larissa, Greece.
FAU - Simopoulos, Constantinos
AU  - Simopoulos C
AD  - Laboratory of Experimental Surgery and Surgical Research, School of Medicine, 
      Democritus University of Thrace, Alexandroupolis, Greece.
LA  - eng
PT  - Journal Article
DEP - 20171114
PL  - Japan
TA  - J Hepatobiliary Pancreat Sci
JT  - Journal of hepato-biliary-pancreatic sciences
JID - 101528587
SB  - IM
MH  - Animals
MH  - Catheter Ablation/*methods
MH  - Hepatectomy/*methods
MH  - Immunohistochemistry
MH  - Liver/*diagnostic imaging/surgery
MH  - Liver Neoplasms, Experimental/diagnosis/*surgery
MH  - Swine
OTO - NOTNLM
OT  - Liver resection
OT  - Radiofrequency
OT  - Tissue injury
EDAT- 2017/10/17 06:00
MHDA- 2018/08/23 06:00
CRDT- 2017/10/17 06:00
PHST- 2017/10/17 06:00 [pubmed]
PHST- 2018/08/23 06:00 [medline]
PHST- 2017/10/17 06:00 [entrez]
AID - 10.1002/jhbp.513 [doi]
PST - ppublish
SO  - J Hepatobiliary Pancreat Sci. 2017 Dec;24(12):657-666. doi: 10.1002/jhbp.513. 
      Epub 2017 Nov 14.