PMID- 29032756
OWN - NLM
STAT- MEDLINE
DCOM- 20180726
LR  - 20180726
IS  - 1875-6212 (Electronic)
IS  - 1570-1611 (Linking)
VI  - 16
IP  - 1
DP  - 2017
TI  - Antidiabetic Drugs as Antihypertensives: New Data on the Horizon.
PG  - 70-78
LID - 10.2174/1570161115666171010122332 [doi]
AB  - BACKGROUND: The prevalence of Type 2 Diabetes Mellitus (T2DM) is increasing 
      worldwide; this is stimulating more research into the optimal management of this 
      disease. Cardiovascular Disease (CVD) remains the commonest cause of death in 
      individuals with T2DM. Besides hyperglycaemia, an explanation for the increased 
      mortality in this population is the increased prevalence of comorbidities, such 
      as hypertension and dyslipidaemia. Recent population-based studies described a 
      prevalence of hypertension >80% in patients with T2DM. In the last decade new 
      classes of antidiabetic medications have been developed that are effective not 
      only for the management of hyperglycaemia and but also for tailoring treatment 
      according to individual needs and characteristics. Regulatory authorities demand 
      the new antidiabetic medications to be examined for Cardiovascular (CV) safety. 
      Interestingly it has been shown, mainly through CV safety trials, that some new 
      antidiabetic medications not only have glucose lowering effects, but also Blood 
      Pressure (BP) lowering effects, contributing to CV risk reduction. CONCLUSION: 
      This review considers the effect of older and newer antidiabetic medications on 
      BP in patients with T2DM.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Mamakou, Vassiliki
AU  - Mamakou V
AD  - First Department of Propaedeutic Internal Medicine, Medical School, National and 
      Kapodistrian University of Athens, Laiko General Hospital, Athens. Greece.
FAU - Eleftheriadou, Ioanna
AU  - Eleftheriadou I
AD  - First Department of Propaedeutic Internal Medicine, Medical School, National and 
      Kapodistrian University of Athens, Laiko General Hospital, Athens. Greece.
FAU - Katsiki, Niki
AU  - Katsiki N
AD  - Second Department of Propaedeutic Internal Medicine, Medical School, Aristotle 
      University of Thessaloniki, Hippocration Hospital, Thessaloniki. Greece.
FAU - Makrilakis, Konstantinos
AU  - Makrilakis K
AD  - First Department of Propaedeutic Internal Medicine, Medical School, National and 
      Kapodistrian University of Athens, Laiko General Hospital, Athens. Greece.
FAU - Tsioufis, Konstantinos
AU  - Tsioufis K
AD  - First Cardiology Clinic, Medical School, National and Kapodistrian University of 
      Athens, Hippokration Hospital, Athens. Greece.
FAU - Tentolouris, Nikolaos
AU  - Tentolouris N
AD  - First Department of Propaedeutic Internal Medicine, Medical School, National and 
      Kapodistrian University of Athens, Laiko General Hospital, Athens. Greece.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Vasc Pharmacol
JT  - Current vascular pharmacology
JID - 101157208
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Antihypertensive Agents/pharmacology/therapeutic use
MH  - Blood Glucose/drug effects
MH  - Blood Pressure/drug effects
MH  - Cardiovascular Diseases/etiology/prevention & control
MH  - Diabetes Mellitus, Type 2/complications/*drug therapy
MH  - Humans
MH  - Hypertension/*drug therapy/etiology/physiopathology
MH  - Hypoglycemic Agents/pharmacology/*therapeutic use
OTO - NOTNLM
OT  - CV
OT  - CVD
OT  - Type 2 diabetes mellitus
OT  - antidiabetic medications
OT  - blood pressure
OT  - cardiovascular disease
EDAT- 2017/10/17 06:00
MHDA- 2018/07/27 06:00
CRDT- 2017/10/17 06:00
PHST- 2017/08/19 00:00 [received]
PHST- 2017/10/06 00:00 [revised]
PHST- 2017/10/07 00:00 [accepted]
PHST- 2017/10/17 06:00 [pubmed]
PHST- 2018/07/27 06:00 [medline]
PHST- 2017/10/17 06:00 [entrez]
AID - CVP-EPUB-86301 [pii]
AID - 10.2174/1570161115666171010122332 [doi]
PST - ppublish
SO  - Curr Vasc Pharmacol. 2017;16(1):70-78. doi: 10.2174/1570161115666171010122332.