PMID- 29033370
OWN - NLM
STAT- MEDLINE
DCOM- 20180709
LR  - 20240327
IS  - 2352-3964 (Electronic)
IS  - 2352-3964 (Linking)
VI  - 25
DP  - 2017 Nov
TI  - d-Ribose as a Contributor to Glycated Haemoglobin.
PG  - 143-153
LID - S2352-3964(17)30393-6 [pii]
LID - 10.1016/j.ebiom.2017.10.001 [doi]
AB  - Glycated haemoglobin (HbA1c) is the most important marker of hyperglycaemia in 
      diabetes mellitus. We show that d-ribose reacts with haemoglobin, thus yielding 
      HbA1c. Using mass spectrometry, we detected glycation of haemoglobin with 
      d-ribose produces 10 carboxylmethyllysines (CMLs). The first-order rate constant 
      of fructosamine formation for d-ribose was approximately 60 times higher than 
      that for d-glucose at the initial stage. Zucker Diabetic Fatty (ZDF) rat, a 
      common model for type 2 diabetes mellitus (T2DM), had high levels of d-ribose and 
      HbA1c, accompanied by a decrease of transketolase (TK) in the liver. The 
      administration of benfotiamine, an activator of TK, significantly decreased 
      d-ribose followed by a decline in HbA1c. In clinical investigation, T2DM patients 
      with high HbA1c had a high level of urine d-ribose, though the level of their 
      urine d-glucose was low. That is, d-ribose contributes to HbA1c, which prompts 
      future studies to further explore whether d-ribose plays a role in the 
      pathophysiological mechanism of T2DM.
CI  - Copyright (c) 2017 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Chen, Xixi
AU  - Chen X
AD  - State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, 
      University of Chinese Academy of Sciences, Beijing 100101, China.
FAU - Su, Tao
AU  - Su T
AD  - State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, 
      University of Chinese Academy of Sciences, Beijing 100101, China.
FAU - Chen, Yao
AU  - Chen Y
AD  - Southwest Medical University, Luzhou, Sichuan 646000, China.
FAU - He, Yingge
AU  - He Y
AD  - State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, 
      University of Chinese Academy of Sciences, Beijing 100101, China.
FAU - Liu, Ying
AU  - Liu Y
AD  - State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, 
      University of Chinese Academy of Sciences, Beijing 100101, China.
FAU - Xu, Yong
AU  - Xu Y
AD  - Southwest Medical University, Luzhou, Sichuan 646000, China.
FAU - Wei, Yan
AU  - Wei Y
AD  - State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, 
      University of Chinese Academy of Sciences, Beijing 100101, China; CAS Key 
      Laboratory of Mental Health, Institute of Psychology, University of Chinese 
      Academy of Sciences, Beijing 100101, China. Electronic address: yanwei@ibp.ac.cn.
FAU - Li, Juan
AU  - Li J
AD  - CAS Key Laboratory of Mental Health, Institute of Psychology, University of 
      Chinese Academy of Sciences, Beijing 100101, China.
FAU - He, Rongqiao
AU  - He R
AD  - State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, 
      University of Chinese Academy of Sciences, Beijing 100101, China; CAS Key 
      Laboratory of Mental Health, Institute of Psychology, University of Chinese 
      Academy of Sciences, Beijing 100101, China; Alzheimer's Disease Center, Beijing 
      Institute for Brain Disorders, Capital Medical University, Beijing 100069, China. 
      Electronic address: herq@ibp.ac.cn.
LA  - eng
PT  - Journal Article
DEP - 20171005
PL  - Netherlands
TA  - EBioMedicine
JT  - EBioMedicine
JID - 101647039
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 681HV46001 (Ribose)
RN  - K3Z4F929H6 (Lysine)
SB  - IM
MH  - Animals
MH  - Biomarkers/*blood
MH  - Blood Glucose
MH  - Diabetes Mellitus, Type 2/*blood/pathology
MH  - Female
MH  - Glycated Hemoglobin/*chemistry
MH  - Glycosylation
MH  - Humans
MH  - Hyperglycemia/blood/pathology
MH  - Lysine/blood
MH  - Male
MH  - Rats
MH  - Rats, Zucker
MH  - Ribose/*blood/chemistry
PMC - PMC5704047
OTO - NOTNLM
OT  - Benfotiamine
OT  - HbA1c
OT  - Transketolase
OT  - Type 2 diabetes mellitus
OT  - d-ribose
EDAT- 2017/10/17 06:00
MHDA- 2018/07/10 06:00
PMCR- 2017/10/05
CRDT- 2017/10/17 06:00
PHST- 2017/08/24 00:00 [received]
PHST- 2017/09/28 00:00 [revised]
PHST- 2017/10/02 00:00 [accepted]
PHST- 2017/10/17 06:00 [pubmed]
PHST- 2018/07/10 06:00 [medline]
PHST- 2017/10/17 06:00 [entrez]
PHST- 2017/10/05 00:00 [pmc-release]
AID - S2352-3964(17)30393-6 [pii]
AID - 10.1016/j.ebiom.2017.10.001 [doi]
PST - ppublish
SO  - EBioMedicine. 2017 Nov;25:143-153. doi: 10.1016/j.ebiom.2017.10.001. Epub 2017 
      Oct 5.