PMID- 29033483
OWN - NLM
STAT- MEDLINE
DCOM- 20180627
LR  - 20181202
IS  - 1998-3751 (Electronic)
IS  - 0253-7613 (Print)
IS  - 0253-7613 (Linking)
VI  - 49
IP  - 3
DP  - 2017 May-Jun
TI  - The impact of antidepressant treatment on brain-derived neurotrophic factor 
      level: An evidence-based approach through systematic review and meta-analysis.
PG  - 236-242
LID - 10.4103/ijp.IJP_700_16 [doi]
AB  - OBJECTIVES: Antidepressant treatment alters brain-derived neurotrophic factor 
      (BDNF) levels, but it is not well established whether BDNF can be used as a 
      marker to prove the efficacy of antidepressant treatment. The present systematic 
      review and meta-analysis aim at assessing the influence of antidepressant 
      treatment on BDNF level and the Hamilton Depression Rating Scale (HDRS) score, 
      thereby to establish the rationale of utilizing BDNF as a predictive biomarker 
      and HDRS score as an indicator for antidepressant treatment efficacy. MATERIALS 
      AND METHODS: Search was conducted in PubMed, Science Direct, and Cochrane 
      databases using the key words "BDNF" and "Depression" and "Antidepressants." On 
      the basis of the inclusion and exclusion criteria, studies were filtered and 
      finally 6 randomized controlled trials were shortlisted. RESULTS: Comparison of 
      serum BDNF level before and after antidepressant treatment was performed and the 
      result showed that antidepressant treatment does not significantly affect the 
      BDNF levels (confidence interval [CI]: -0.483 to 0.959; standard mean difference 
      [SMD]: 0.238, P = 0.518). Egger's regression test (P = 0.455) and heterogeneity 
      test (I(2) = 88.909%) were done. Similarly, comparison of HDRS scores before and 
      after antidepressant treatment indicated improvement in HDRS score suggesting 
      positive outcome (CI: 1.719 to 3.707; SMD: 2.713, P < 0.001). Egger's regression 
      test (P = 0.1417) and heterogeneity test (I(2) = 89.843%) were performed. 
      Publication bias was observed by funnel plot. CONCLUSION: Changes in BDNF levels 
      do not occur uniformly for all the antidepressants. Hence, to use BDNF as a 
      biomarker, it needs to be seen whether the same is true for all antidepressants.
FAU - Arumugam, Vijayakumar
AU  - Arumugam V
AD  - Department of Pharmacy Practice, Drug and Poison Information Center, KMCH College 
      of Pharmacy, Coimbatore, Tamil Nadu, India.
FAU - John, Vini Susan
AU  - John VS
AD  - Department of Pharmacy Practice, Drug and Poison Information Center, KMCH College 
      of Pharmacy, Coimbatore, Tamil Nadu, India.
FAU - Augustine, Nisha
AU  - Augustine N
AD  - Department of Pharmacy Practice, Drug and Poison Information Center, KMCH College 
      of Pharmacy, Coimbatore, Tamil Nadu, India.
FAU - Jacob, Taniya
AU  - Jacob T
AD  - Department of Pharmacy Practice, Drug and Poison Information Center, KMCH College 
      of Pharmacy, Coimbatore, Tamil Nadu, India.
FAU - Joy, Sagar Maliakkal
AU  - Joy SM
AD  - Department of Pharmacy Practice, Drug and Poison Information Center, KMCH College 
      of Pharmacy, Coimbatore, Tamil Nadu, India.
FAU - Sen, Suchandra
AU  - Sen S
AD  - Department of Pharmacy Practice, Drug and Poison Information Center, KMCH College 
      of Pharmacy, Coimbatore, Tamil Nadu, India.
FAU - Sen, Tuhinadri
AU  - Sen T
AD  - Department of Pharmaceutical Technology, Division of Pharmacology, Jadavpur 
      University, Kolkata, West Bengal, India.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
PL  - India
TA  - Indian J Pharmacol
JT  - Indian journal of pharmacology
JID - 7902477
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Antidepressive Agents/*pharmacology/therapeutic use
MH  - Brain Chemistry/*drug effects
MH  - Brain-Derived Neurotrophic Factor/blood/*metabolism
MH  - Depression/*drug therapy/*metabolism/psychology
MH  - Humans
MH  - Psychiatric Status Rating Scales
MH  - Treatment Outcome
PMC - PMC5637134
OTO - NOTNLM
OT  - Antidepressants
OT  - Hamilton rating scale for depression
OT  - brain-derived neurotrophic factor
OT  - depression
OT  - meta-analysis
COIS- There are no conflicts of interest.
EDAT- 2017/10/17 06:00
MHDA- 2018/06/28 06:00
PMCR- 2017/05/01
CRDT- 2017/10/17 06:00
PHST- 2017/10/17 06:00 [entrez]
PHST- 2017/10/17 06:00 [pubmed]
PHST- 2018/06/28 06:00 [medline]
PHST- 2017/05/01 00:00 [pmc-release]
AID - IJPharm-49-236 [pii]
AID - 10.4103/ijp.IJP_700_16 [doi]
PST - ppublish
SO  - Indian J Pharmacol. 2017 May-Jun;49(3):236-242. doi: 10.4103/ijp.IJP_700_16.