PMID- 29033933
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 8
DP  - 2017
TI  - Monocyte Chemotactic Protein 1 in Plasma from Soluble Leishmania 
      Antigen-Stimulated Whole Blood as a Potential Biomarker of the Cellular Immune 
      Response to Leishmania infantum.
PG  - 1208
LID - 10.3389/fimmu.2017.01208 [doi]
LID - 1208
AB  - New biomarkers are needed to identify asymptomatic Leishmania infection as well 
      as immunity following vaccination or treatment. With the aim of finding a robust 
      biomarker to assess an effective cellular immune response, monocyte chemotactic 
      protein 1 (MCP-1) was examined in plasma from soluble Leishmania antigen 
      (SLA)-stimulated whole blood collected from subjects living in a Leishmania 
      infantum-endemic area. MCP-1, expressed 110 times more strongly than IL-2, 
      identified 87.5% of asymptomatic subjects and verified some asymptomatic subjects 
      close to the cutoff. MCP-1 was also significantly elevated in all patients cured 
      of visceral leishmaniasis (VL), unlike IL-2, indicating the specific memory 
      response generated against Leishmania. These results show MCP-1 to be a robust 
      candidate biomarker of immunity that could be used as a marker of cure and to 
      both select and follow the population in vaccine phase I-III human clinical 
      trials with developed rapid, easy-to-use field tools.
FAU - Ibarra-Meneses, Ana V
AU  - Ibarra-Meneses AV
AD  - WHO Collaborating Centre for Leishmaniasis, Centro Nacional de Microbiologia, 
      Instituto de Salud Carlos III, Madrid, Spain.
FAU - Sanchez, Carmen
AU  - Sanchez C
AD  - WHO Collaborating Centre for Leishmaniasis, Centro Nacional de Microbiologia, 
      Instituto de Salud Carlos III, Madrid, Spain.
FAU - Alvar, Jorge
AU  - Alvar J
AD  - Drugs for Neglected Diseases Initiative (DNDi), Geneva, Switzerland.
FAU - Moreno, Javier
AU  - Moreno J
AD  - WHO Collaborating Centre for Leishmaniasis, Centro Nacional de Microbiologia, 
      Instituto de Salud Carlos III, Madrid, Spain.
FAU - Carrillo, Eugenia
AU  - Carrillo E
AD  - WHO Collaborating Centre for Leishmaniasis, Centro Nacional de Microbiologia, 
      Instituto de Salud Carlos III, Madrid, Spain.
LA  - eng
PT  - Journal Article
DEP - 20170929
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC5626820
OTO - NOTNLM
OT  - asymptomatic infection
OT  - biomarker
OT  - chemokines
OT  - cytokines
OT  - leishmaniasis
OT  - monocyte chemotactic protein 1
OT  - treatment
OT  - whole blood assay
EDAT- 2017/10/17 06:00
MHDA- 2017/10/17 06:01
PMCR- 2017/01/01
CRDT- 2017/10/17 06:00
PHST- 2017/07/14 00:00 [received]
PHST- 2017/09/12 00:00 [accepted]
PHST- 2017/10/17 06:00 [entrez]
PHST- 2017/10/17 06:00 [pubmed]
PHST- 2017/10/17 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2017.01208 [doi]
PST - epublish
SO  - Front Immunol. 2017 Sep 29;8:1208. doi: 10.3389/fimmu.2017.01208. eCollection 
      2017.