PMID- 29034353
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240328
IS  - 2451-9022 (Print)
IS  - 2451-9030 (Electronic)
IS  - 2451-9022 (Linking)
VI  - 2
IP  - 6
DP  - 2017 Sep
TI  - The Default Mode Network in Autism.
PG  - 476-486
LID - 10.1016/j.bpsc.2017.04.004 [doi]
AB  - Autism spectrum disorder (ASD) is characterized by deficits in social 
      communication and interaction. Since its discovery as a major functional brain 
      system, the default mode network (DMN) has been implicated in a number of 
      psychiatric disorders, including ASD. Here we review converging multimodal 
      evidence for DMN dysfunction in the context of specific components of social 
      cognitive dysfunction in ASD: 'self-referential processing' - the ability to 
      process social information relative to oneself and 'theory of mind' or 
      'mentalizing' - the ability to infer the mental states such as beliefs, 
      intentions, and emotions of others. We show that altered functional and 
      structural organization of the DMN, and its atypical developmental trajectory, 
      are prominent neurobiological features of ASD. We integrate findings on atypical 
      cytoarchitectonic organization and imbalance in excitatory-inhibitory circuits, 
      which alter local and global brain signaling, to scrutinize putative mechanisms 
      underlying DMN dysfunction in ASD. Our synthesis of the extant literature 
      suggests that aberrancies in key nodes of the DMN and their dynamic functional 
      interactions contribute to atypical integration of information about the self in 
      relation to 'other', as well as impairments in the ability to flexibly attend to 
      socially relevant stimuli. We conclude by highlighting open questions for future 
      research.
FAU - Padmanabhan, Aarthi
AU  - Padmanabhan A
AD  - Department of Psychiatry and Behavioral Sciences, Stanford University School of 
      Medicine, Stanford, CA.
FAU - Lynch, Charles J
AU  - Lynch CJ
AD  - Department of Psychology, Georgetown University, Washington, DC.
FAU - Schaer, Marie
AU  - Schaer M
AD  - University of Geneva, Department of Psychiatry, Geneva, Switzerland.
FAU - Menon, Vinod
AU  - Menon V
AD  - Department of Psychiatry and Behavioral Sciences, Stanford University School of 
      Medicine, Stanford, CA.
AD  - Program in Neuroscience, Stanford University School of Medicine, Stanford, CA.
AD  - Department of Neurology and Neurological Sciences, Stanford University School of 
      Medicine, Stanford, CA.
LA  - eng
GR  - R01 HD059205/HD/NICHD NIH HHS/United States
GR  - R01 MH084164/MH/NIMH NIH HHS/United States
GR  - R01 NS086085/NS/NINDS NIH HHS/United States
GR  - RF1 NS086085/NS/NINDS NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Biol Psychiatry Cogn Neurosci Neuroimaging
JT  - Biological psychiatry. Cognitive neuroscience and neuroimaging
JID - 101671285
PMC - PMC5635856
MID - NIHMS884029
OTO - NOTNLM
OT  - Autism
OT  - default mode network
OT  - mentalizing
OT  - self-referential processing
OT  - social
OT  - theory of mind
COIS- Financial Disclosure: All authors repot no financial interests or potential 
      conflicts of interest
EDAT- 2017/10/17 06:00
MHDA- 2017/10/17 06:01
PMCR- 2018/09/01
CRDT- 2017/10/17 06:00
PHST- 2017/10/17 06:00 [entrez]
PHST- 2017/10/17 06:00 [pubmed]
PHST- 2017/10/17 06:01 [medline]
PHST- 2018/09/01 00:00 [pmc-release]
AID - 10.1016/j.bpsc.2017.04.004 [doi]
PST - ppublish
SO  - Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Sep;2(6):476-486. doi: 
      10.1016/j.bpsc.2017.04.004.