PMID- 29034562
OWN - NLM
STAT- MEDLINE
DCOM- 20181022
LR  - 20181022
IS  - 1463-5224 (Electronic)
IS  - 1463-5216 (Linking)
VI  - 21
IP  - 4
DP  - 2018 Jul
TI  - Canine central corneal thickness measurements via Pentacam-HR((R)) , optical 
      coherence tomography (Optovue iVue((R)) ), and high-resolution ultrasound 
      biomicroscopy.
PG  - 362-370
LID - 10.1111/vop.12518 [doi]
AB  - OBJECTIVE: To compare central corneal thickness (CCT) values in canine eyes using 
      Pentacam-HR((R)) Scheimpflug imaging (Pentacam), Optovue((R)) iVue spectral-domain 
      optical coherence tomography (SD-OCT), and high-resolution ultrasound 
      biomicroscopy (UBM) and generate normative canine Pentacam CCT values. ANIMALS 
      STUDIED: Twenty-four client-owned dogs (37 eyes) with nondiseased cornea(s) 
      presenting to the Colorado State University Veterinary Teaching Hospital. 
      PROCEDURES: Corneal images were acquired via Pentacam, SD-OCT, and UBM in the 
      listed order. Machine-calculated values of CCT from Pentacam and SD-OCT were 
      compared to operator-measured values from UBM. Bland-Altman analysis was 
      performed to evaluate agreement between instruments. RESULTS: Mean CCT +/- SD 
      measured by Pentacam was 629.73 +/- 64.57 mum, by SD-OCT was 610.56 +/- 57.48 mum, and 
      by UBM was 689.77 +/- 55.93 mum. On average, Pentacam CCT was 19.17 +/- 32.90 mum (3%) 
      thicker than SD-OCT and 65.12 +/- 44.52 mum (10.3%) thinner than UBM. SD-OCT was on 
      average 82.47 mum (13.5% ) thinner than UBM. The 95% limits of agreement were 
      (-45.31, 83.65), (-152.38, 22.13), and (-126.674, -38.270) for Pentacam vs. 
      SD-OCT, Pentacam vs. UBM, and SD-OCT vs. UBM respectively. All differences were 
      statistically significant (P < 0.01). CONCLUSIONS: Considering there is an 
      average of 7.5% normal diurnal variation in canine CCT, a 3.0% difference between 
      Pentacam and SD-OCT values is likely not clinically relevant. However, Pentacam 
      measurements were both statistically and clinically significantly different from 
      UBM and SD-OCT measurements.
CI  - (c) 2017 American College of Veterinary Ophthalmologists.
FAU - Wolfel, Allison E
AU  - Wolfel AE
AD  - Department of Clinical Sciences, College of Veterinary Medicine and Biomedical 
      Sciences, Colorado State University, Fort Collins, CO, 80523, USA.
FAU - Pederson, Samantha L
AU  - Pederson SL
AD  - Department of Clinical Sciences, College of Veterinary Medicine and Biomedical 
      Sciences, Colorado State University, Fort Collins, CO, 80523, USA.
FAU - Cleymaet, Allison M
AU  - Cleymaet AM
AD  - Department of Clinical Sciences, College of Veterinary Medicine and Biomedical 
      Sciences, Colorado State University, Fort Collins, CO, 80523, USA.
FAU - Hess, Ann M
AU  - Hess AM
AD  - Department of Statistics, College of Natural Sciences, Colorado State University, 
      Fort Collins, CO, 80523, USA.
FAU - Freeman, Kate S
AU  - Freeman KS
AD  - Department of Clinical Sciences, College of Veterinary Medicine and Biomedical 
      Sciences, Colorado State University, Fort Collins, CO, 80523, USA.
LA  - eng
PT  - Journal Article
DEP - 20171015
PL  - England
TA  - Vet Ophthalmol
JT  - Veterinary ophthalmology
JID - 100887377
SB  - IM
MH  - Animals
MH  - Cornea/*anatomy & histology/diagnostic imaging
MH  - Corneal Pachymetry/methods/*veterinary
MH  - Dogs/*anatomy & histology
MH  - Female
MH  - Male
MH  - Microscopy, Acoustic/methods/*veterinary
MH  - Reference Values
MH  - Reproducibility of Results
MH  - Tomography, Optical Coherence/methods/*veterinary
OTO - NOTNLM
OT  - Pentacam
OT  - Scheimpflug
OT  - canine
OT  - central corneal thickness
OT  - optical coherence tomography
OT  - ultrasound biomicroscopy
EDAT- 2017/10/17 06:00
MHDA- 2018/10/23 06:00
CRDT- 2017/10/17 06:00
PHST- 2017/10/17 06:00 [pubmed]
PHST- 2018/10/23 06:00 [medline]
PHST- 2017/10/17 06:00 [entrez]
AID - 10.1111/vop.12518 [doi]
PST - ppublish
SO  - Vet Ophthalmol. 2018 Jul;21(4):362-370. doi: 10.1111/vop.12518. Epub 2017 Oct 15.